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Search results:

General Information

• Evidence
• Gene
• mRNA
• CDS
• Protein
• PTM
• Enzyme
• PPi
• Pathway
• Structural
• Domain
• Ontology
• SNP
• Drug
• External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
23325601	2013	Cell line : HepG2, Huh7 , RKO Source : Cell Culture core facility at the University of Southern California Research Center for Liver Diseases. Giordano (Whipps Cross University Hospital, London, UK) Sample Type : CRC tumor and normal tissue No. of Sample : 16 Stage : -	Coimmunoprecipitation, immunohistochemistry and western blotting, pull-down assays	Up-regulation	-	MAT2B and GIT1 form a scaffold, which recruits and activates MEK and ERK to promote growth and tumorigenesis. This novel MAT2B/GIT1 complex may provide a potential therapeutic gateway in human liver and colon cancer.

Gene Details

NC_000017.10 (27900487..27916610, complement)
View Larger Image   

Gene Type	protein coding
Gene Family	ADP-ribosylation factor GTPase activating proteins, "Ankyrin repeat domain containing"
Description	-
Chromosome	17
Location	17p11.2
Start	27900487
End	27916610
Strand	-
Gene Sequence	Download   Select all
Length	16124
OMIM ID	608434
HGNC ID	HGNC:4272
Unigene ID	Hs.514051
Ensembl ID	ENSG00000108262
PharmGKB ID	PA28683

mRNA Information

mRNA ID	?NM_001085454.1
Exon
mRNA Sequence	Download   Select all
Length

CDS Information

   

Location
CDS Sequence	Download   Select all
CCDS ID	CCDS11250.1

Protein Information

      

Protein ID	NP_001078923.1
Protein Name	G protein-coupled receptor kinase interacting ArfGAP 1
Molecular Wt. (Da)	0
Protein Sequence	Download   Select all
Length	761
Uniprot ID	Q9NYS7
Ensembl Protein ID	ENSP00000319474

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
Y	Phosphorylation	598
Y	Phosphorylation	246
Y	Phosphorylation	284
S	Phosphorylation	362
Y	Phosphorylation	383
S	Phosphorylation	385
S	Phosphorylation	388
T	Phosphorylation	392
S	Phosphorylation	410
T	Phosphorylation	480
Y	Phosphorylation	510
S	Phosphorylation	536
T	Phosphorylation	537
Y	Phosphorylation	545
S	Phosphorylation	546
Y	Phosphorylation	554
S	Phosphorylation	563
S	Phosphorylation	592
S	Phosphorylation	596
T	Phosphorylation	601
S	Phosphorylation	630
Y	Phosphorylation	554;-
Y	Phosphorylation	563;-
S	Phosphorylation	362;-
S	Phosphorylation	371;-
T	Phosphorylation	364;-
T	Phosphorylation	373;-
Y	Phosphorylation	554;-
S	Phosphorylation	359;-
S	Phosphorylation	368;-
S	Phosphorylation	601;-
Y	Phosphorylation	607;-
T	Phosphorylation	610;-
S	Phosphorylation	394;-
S	Phosphorylation	397;-
S	Phosphorylation	373
S	Phosphorylation	382
Y	Phosphorylation	392
T	Phosphorylation	401
S	Phosphorylation	419
S	Phosphorylation	413
S	Phosphorylation	422
S	Phosphorylation	414
S	Phosphorylation	423
S	Phosphorylation	417
S	Phosphorylation	426
S	Phosphorylation	605
S	Phosphorylation	361
S	Phosphorylation	370
S	Phosphorylation	134
S	Phosphorylation	134
S	Phosphorylation	375
S	Phosphorylation	384
T	Phosphorylation	491
T	Phosphorylation	499
T	Phosphorylation	500
T	Phosphorylation	508
Y	Phosphorylation	519
S	Phosphorylation	555
S	Phosphorylation	588
S	Phosphorylation	597

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                    

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
156	ADRBK1	182	NP_001610.2	in vivo	9826657
157	ADRBK2	183	NP_005151.2	in vivo	9826657
547	KIF1A	3156	NP_004312.2	in vivo	12522103
580	BARD1	3354	NP_000456.2	in vitro;yeast 2-hybrid	15383276
2869	GRK5	2926	NP_005299.1	in vivo	9826657
2870	GRK6	2925	NP_002073.2	in vivo	9826657
3064	HTT	883	NP_002102.4	in vitro;in vivo;yeast 2-hybrid	15383276
5063	PAK3	2142	NP_001121640.1	in vivo	10896954
5335	PLCG1	1398	NP_002651.2	in vitro;in vivo	14523024
5747	PTK2	2859	NP_005598.3	in vitro;in vivo	10938112
5803	PTPRZ1	1481	NP_002842.2	in vivo;yeast 2-hybrid	11381105
5829	PXN	3937	BAA18998.1	in vivo	12   153   727   108   969   500   000   000   000   000   000
5901	RAN	3109	NP_006316.1	yeast 2-hybrid	15383276
6714	SRC	1819	NP_005408.1	in vitro;in vivo	14523024
7041	TGFB1I1	3831	NP_001035919.1	in vitro;in vivo;yeast 2-hybrid	12153727
8499	PPFIA2	4392	NP_003616.2	in vitro;in vivo;yeast 2-hybrid	12629171
8541	PPFIA3	4393	NP_003651.1	in vitro;yeast 2-hybrid	12923177
8874	ARHGEF7	5688	NP_001106983.1	in vitro;in vivo;yeast 2-hybrid	1   089   695   416   628   220
9001	HAP1	2972	NP_003940.3	in vitro;yeast 2-hybrid	15383276
9459	ARHGEF6	2226	NP_004831.1	yeast 2-hybrid	10896954
10542	HBXIP	9773	NP_006393.2	yeast 2-hybrid	16169070
11243	PMF1	11441	NP_009152.2	yeast 2-hybrid	16169070
29070	CCDC113	7121	NP_054876.2	yeast 2-hybrid	16169070
51593	SRRT	10665	NP_056992.4	yeast 2-hybrid	16169070
55183	RIF1	10603	NP_060621.3	yeast 2-hybrid	15383276
55339	WDR33	11680	NP_060853.3	yeast 2-hybrid	16169070
57761	TRIB3	9836	NP_066981.2	yeast 2-hybrid	16169070
65265	C8orf33	7951	NP_075568.1	yeast 2-hybrid	16169070

Pathway Information

                  

Pathway Name	Pathway ID
Endocytosis	hsa04144
Epithelial cell signaling in Helicobacter pylori infection	hsa05120
Regulation of actin cytoskeleton	hsa04810

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00204	123-220	ANK
cl02529	123-220	ANK superfamily
pfam12205	632-756	GIT1_C
cl20096	632-756	GIT1_C superfamily
smart00105	3-124	ArfGap
cl02464	3-124	ArfGap superfamily
pfam01412	10-119	ArfGap
cd00204	123-222	ANK
pfam08518	328-358	GIT_SHD
cl23377	328-358	GIT_SHD superfamily
smart00555	328-358	GIT
cl23056	328-358	GIT superfamily
pfam08518	272-294	GIT_SHD
cl23377	272-294	GIT_SHD superfamily
smart00555	272-294	GIT
cl23056	272-294	GIT superfamily
pfam00023	166-197	Ank
pfam07558	441-473	Shugoshin_N
cl06547	441-473	Shugoshin_N superfamily
pfam12796	137-229	Ank_2
COG5347	3-117	COG5347
PLN03114	Sep-64	PLN03114
COG0666	37-243	ANKYR
pfam13857	152-207	Ank_5
pfam12796	137-197	Ank_2
PTZ00322	118-228	PTZ00322
pfam13637	167-220	Ank_4
PHA02875	128-221	PHA02875
PHA02878	152-248	PHA02878
PHA02874	120-221	PHA02874
PHA02878	137-251	PHA02878
pfam13637	137-179	Ank_4
PHA02875	126-221	PHA02875

Ontology Information

   

HPRD ID	6068
Molecular Class	GTPase activating protein
Molecular Function	Transporter activity (GO:0005215)
Biological Process	Transport (GO:0006810)

SNP Information

View SNP Geneview Report   

Drug Information

No matching records could be found.

External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO