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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17683069 | 2007 | Cell line : SW480, Colo320, HCT116 Source : ATCC Sample Type : - No. of Sample : - Stage : - | real time RT-PCR,western blotting | Up-regulation | - | - |
| 23097684 | 2012 | Cell line : HT29, HCT116, SW480 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Annexin V,PI staining and flow cytometry,Western blotting,Confocal microscopy | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, C2H2-type |
| Description | This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008] | Chromosome | 2 |
| Location | 2q14 |
| Start | 121493441 |
| End | 121750229 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 256789 |
| OMIM ID | 165230 |
| HGNC ID | HGNC:4318 |
| Unigene ID | Hs.111867 |
| Ensembl ID | ENSG00000074047 |
| PharmGKB ID | PA28721 |
mRNA Information
| mRNA ID | NM_005270.4 |
|---|---|
| Exon | join(1..178,130071..130176,153953..154155,157955..158140, 171424..171625,173103..173316,174651..174773, 177634..177819,181144..181293,185426..185590, 187181..187453,188988..189324,190918..195363) | mRNA Sequence | Download Select all |
| Length | 6780 |
Protein Information
| Protein ID | NP_005261.2 |
|---|---|
| Protein Name | 167653 |
| Molecular Wt. (Da) | 1586 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | P04844 |
| Ensembl Protein ID | ENSP00000237530 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 234 |
| S | Phosphorylation | 236 |
| S | Phosphorylation | 149 |
| S | Phosphorylation | 239 |
| S | Phosphorylation | 242 |
| S | Phosphorylation | 859 |
| S | Phosphorylation | 866 |
| S | Phosphorylation | 1187 |
| S | Phosphorylation | 1194 |
| S | Phosphorylation | 842 |
| S | Phosphorylation | 849 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1385 | CREB1 | 442 | NP_604391.1 | in vitro;in vivo | 10074179 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Hedgehog signaling pathway | hsa04340 |
| Hippo signaling pathway | hsa04390 |
| Pathways in cancer | hsa05200 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam13465 | 519-546 | zf-H2C2_2 |
| cl22375 | 519-546 | zf-H2C2_2 superfamily |
| pfam13465 | 489-516 | zf-H2C2_2 |
| cl22375 | 489-516 | zf-H2C2_2 superfamily |
| pfam09606 | 1170-1496 | Med15 |
| pfam09606 | 1117-1492 | Med15 |
| COG5189 | 499-589 | SFP1 |
| pfam09606 | 1079-1503 | Med15 |
| pfam09770 | 1160-1348 | PAT1 |
| COG5048 | 501-581 | COG5048 |
| pfam09770 | 1265-1491 | PAT1 |
| PHA03247 | 912-1389 | PHA03247 |
| COG5048 | 493-549 | COG5048 |
| COG5048 | 459-584 | COG5048 |
| PHA03378 | 1249-1505 | PHA03378 |
| pfam07223 | 1250-1497 | DUF1421 |
Ontology Information
| HPRD ID | 4690 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Structural constituent of ribosome (GO:0003735) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.