Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GLI3 | 2737 | GLI family zinc finger 3 | 7 | PAP-A, PAPA, PAPA1, PAPB, ACLS, PPDIV |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17683069 | 2007 | Cell line : SW480, Colo320, HCT116 Source : ATCC Sample Type : - No. of Sample : - Stage : - | real time RT-PCR,western blotting | Up-regulation | - | - |
| 22227409 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and adjecent normal tissues No. of Sample : - Stage : - | real time RT-PCR | Up-regulation | - | Gli3 antagonists as a novel treatment option for colon cancer |
| 23176625 | 2013 | Cell line : DLD 1, HCT116 , HT29, SW480 Source : ATCC Sample Type : - No. of Sample : - Stage : - | real time RT-PCR, immunocytochemistry | Up-regulation | - | Activator Gli3 signal augments tumorigenicity of colorectal cancer irrespective of p53 status. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, C2H2-type |
| Description | This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008] | Chromosome | 7 |
| Location | 7p13 |
| Start | 42000547 |
| End | 42277469 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 276923 |
| OMIM ID | 165240 |
| HGNC ID | HGNC:4319 |
| Unigene ID | Hs.21509 |
| Ensembl ID | ENSG00000106571 |
| PharmGKB ID | PA28722 |
mRNA Information
| mRNA ID | XM_011515273.1 |
|---|---|
| Exon | join(1..119,40818..40983,115645..115887,187256..187361, 215417..215622,218583..218729,223874..224075, 237701..237914,238736..238849,240505..240645, 285365..285514,286391..286555,291486..291776, 296190..296517,297472..303164) | mRNA Sequence | Download Select all |
| Length | 8285 |
Protein Information
| Protein ID | XP_011513575.1 |
|---|---|
| Protein Name | 169733 |
| Molecular Wt. (Da) | 1580 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | P15880 |
| Ensembl Protein ID | ENSP00000341885 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 19;- |
| S | Phosphorylation | 19;- |
| S | Phosphorylation | 664 |
| S | Phosphorylation | 664 |
| T | Phosphorylation | 669 |
| T | Phosphorylation | 669 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6497 | SKI | 1271 | NP_003027.1 | in vitro;in vivo | 12435627 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| cAMP signaling pathway | hsa04024 |
| Hedgehog signaling pathway | hsa04340 |
| Pathways in cancer | hsa05200 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam13465 | 562-589 | zf-H2C2_2 |
| cl22375 | 562-589 | zf-H2C2_2 superfamily |
| pfam13465 | 532-559 | zf-H2C2_2 |
| cl22375 | 532-559 | zf-H2C2_2 superfamily |
| COG5189 | 542-632 | SFP1 |
| COG5048 | 551-624 | COG5048 |
Ontology Information
| HPRD ID | 2427 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Structural constituent of ribosome (GO:0003735) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.