Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GNB4 | 59345 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | 3 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19414374 | 2009 | Cell line : - Source : Department of General Surgery at the Klinikum Herford. Sample Type : Tumor and normal tissue No. of Sample : 136 colorectal cancer patients Stage : Stage III and IV. | - | Polymorhpism | - | Intron-1 haplotypes of GNB4 might be predictive markers for survival of patients with advanced colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | WD repeat domain containing |
| Description | Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. [provided by RefSeq, Jul 2008] | Chromosome | 3 |
| Location | 3q27.1 |
| Start | 179113876 |
| End | 179169371 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 55496 |
| OMIM ID | 610863 |
| HGNC ID | HGNC:20731 |
| Unigene ID | Hs.173030 |
| Ensembl ID | ENSG00000114450 |
| PharmGKB ID | PA134864200 |
Protein Information
| Protein ID | NP_067642.1 |
|---|---|
| Protein Name | guanine nucleotide binding protein (G protein), beta polypeptide 4 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 340 |
| Uniprot ID | Q9Y4G6 |
| Ensembl Protein ID | ENSP00000303476 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Alcoholism | hsa05034 |
| Chemokine signaling pathway | hsa04062 |
| Cholinergic synapse | hsa04725 |
| Circadian entrainment | hsa04713 |
| Dopaminergic synapse | hsa04728 |
| GABAergic synapse | hsa04727 |
| Glutamatergic synapse | hsa04724 |
| Morphine addiction | hsa05032 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Ras signaling pathway | hsa04014 |
| Retrograde endocannabinoid signaling | hsa04723 |
| Serotonergic synapse | hsa04726 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00200 | 48-340 | WD40 |
| cl02567 | 48-340 | WD40 superfamily |
| cd00200 | 218-340 | WD40 |
| pfam00400 | 216-254 | WD40 |
| smart00320 | 215-254 | WD40 |
| pfam00400 | 175-212 | WD40 |
| pfam00400 | 49-83 | WD40 |
| smart00320 | 49-83 | WD40 |
| smart00320 | 173-212 | WD40 |
| pfam00400 | 302-340 | WD40 |
| smart00320 | 307-340 | WD40 |
| pfam00400 | 137-170 | WD40 |
| smart00320 | 134-170 | WD40 |
| pfam00400 | 263-298 | WD40 |
| COG2319 | 25-340 | WD40 |
| COG2319 | 26-340 | WD40 |
| COG2319 | 49-322 | WD40 |
| COG2319 | 48-279 | WD40 |
| PLN00181 | 34-193 | PLN00181 |
| PLN00181 | 97-331 | PLN00181 |
| PTZ00421 | 153-301 | PTZ00421 |
Ontology Information
| HPRD ID | 11047 |
|---|---|
| Molecular Class | G protein |
| Molecular Function | Growth factor activity (GO:0008083) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.