Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GNB5 | 10681 | guanine nucleotide binding protein (G protein), beta 5  | 15 | GB5  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24172857    | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Whole exome sequencing | Mutation | - | Some of these mutated genes (ADCY9, ADCY2, GNB5, K-ras, HDAC6 and ARHGEF17) also belong to the 'Phospholipase C Signaling' network, which suggests that this pathway and its mutated genes may contribute to a lung metastasis from colon cancer. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | WD repeat domain containing |
| Description | Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008]   | Chromosome | 15 |
| Location | 15q21.2 |
| Start | 52413123   |
| End | 52483565   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 70443   |
| OMIM ID | 604447    |
| HGNC ID | HGNC:4401    |
| Unigene ID | Hs.155090    |
| Ensembl ID | ENSG00000069966    |
| PharmGKB ID | PA28780    |
mRNA Information
| mRNA ID | ?NM_006578.3 |
|---|---|
| Exon |   | mRNA Sequence |    Download   Select all |
| Length |   |
CDS Information
| Location | |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS10149.1 |    
Protein Information
| Protein ID | NP_006569.1 |
|---|---|
| Protein Name | guanine nucleotide binding protein (G protein), beta 5 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence |    Download   Select all |
| Length | 395   |
| Uniprot ID | Q9HB71 |    
| Ensembl Protein ID | ENSP00000356652   |    
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2792 |    GNGT1 |    1805 |    NP_068774.1 |    yeast 2-hybrid |    8636150    |
| 6000 |    RGS7 |    3948 |    NP_002915.3 |    in vitro |    1   052   150   910   051   670    |
| 8786 |    RGS11 |    4872 |    NP_899180.1 |    in vitro;in vivo |    9   789   084   103   396   150   000   000    |
| 9628 |    RGS6 |    4871 |    AAD34717.1 |    in vitro;in vivo |    1   033   961   510   521   500    |
| 93145 |    OLFM2 |    10127 |    NP_477512.1 |    yeast 2-hybrid |    16169070    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Alcoholism |    hsa05034 |    
| Chemokine signaling pathway |    hsa04062 |    
| Cholinergic synapse |    hsa04725 |    
| Circadian entrainment |    hsa04713 |    
| Dopaminergic synapse |    hsa04728 |    
| GABAergic synapse |    hsa04727 |    
| Glutamatergic synapse |    hsa04724 |    
| Morphine addiction |    hsa05032 |    
| Pathways in cancer |    hsa05200 |    
| PI3K-Akt signaling pathway |    hsa04151 |    
| Ras signaling pathway |    hsa04014 |    
| Retrograde endocannabinoid signaling |    hsa04723 |    
| Serotonergic synapse |    hsa04726 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00200 | 98-395  | WD40 |
| cl02567 | 98-395  | WD40 superfamily |
| cd00200 | 229-394  | WD40 |
| cd00200 | 95-267  | WD40 |
| pfam00400 | 95-133  | WD40 |
| smart00320 | 95-133  | WD40 |
| pfam00400 | 357-394  | WD40 |
| smart00320 | 356-394  | WD40 |
| pfam00400 | 271-309  | WD40 |
| smart00320 | 270-309  | WD40 |
| pfam00400 | 227-267  | WD40 |
| smart00320 | 226-267  | WD40 |
| pfam00400 | 194-223  | WD40 |
| smart00320 | 194-223  | WD40 |
| COG2319 | 96-394  | WD40 |
| COG2319 | 96-394  | WD40 |
| COG2319 | 96-372  | WD40 |
| COG2319 | 98-334  | WD40 |
| PLN00181 | 256-394  | PLN00181 |
| PTZ00421 | 207-317  | PTZ00421 |
| PLN00181 | 150-354  | PLN00181 |
| PTZ00421 | 334-393  | PTZ00421 |
| PTZ00421 | 194-282  | PTZ00421 |
| COG2319 | 333-394  | WD40 |
Ontology Information
| HPRD ID | 5659 |    
|---|---|
| Molecular Class | Not Available |
| Molecular Function | Lipid binding (GO:0008289) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
