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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
GNB5 10681 guanine nucleotide binding protein (G protein), beta 5  15GB5 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24172857   2014Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Whole exome sequencing Mutation-Some of these mutated genes (ADCY9, ADCY2, GNB5, K-ras, HDAC6 and ARHGEF17) also belong to the 'Phospholipase C Signaling' network, which suggests that this pathway and its mutated genes may contribute to a lung metastasis from colon cancer.


Gene Details



NC_000015.9 (52413123..52483565, complement)

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Gene Type protein coding
Gene Family WD repeat domain containing
Description Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008]  
Chromosome 15
Location 15q21.2
Start 52413123  
End 52483565  
Strand -  
Gene Sequence

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Length 70443  
OMIM ID 604447   
HGNC ID HGNC:4401   
Unigene ID Hs.155090   
Ensembl ID ENSG00000069966   
PharmGKB ID PA28780   

mRNA Information


mRNA ID ?NM_006578.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS10149.1



Protein Information


      
Protein IDNP_006569.1
Protein Nameguanine nucleotide binding protein (G protein), beta 5
Molecular Wt. (Da)0
Protein Sequence

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Length 395  
Uniprot IDQ9HB71
Ensembl Protein ID ENSP00000356652  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2792GNGT11805NP_068774.1yeast 2-hybrid8636150   
6000RGS73948NP_002915.3in vitro1   052   150   910   051   670   
8786RGS114872NP_899180.1in vitro;in vivo9   789   084   103   396   150   000   000   
9628RGS64871AAD34717.1in vitro;in vivo1   033   961   510   521   500   
93145OLFM210127NP_477512.1yeast 2-hybrid16169070   


Pathway Information


                                                                              
Pathway Name Pathway ID
Alcoholism hsa05034
Chemokine signaling pathway hsa04062
Cholinergic synapse hsa04725
Circadian entrainment hsa04713
Dopaminergic synapse hsa04728
GABAergic synapse hsa04727
Glutamatergic synapse hsa04724
Morphine addiction hsa05032
Pathways in cancer hsa05200
PI3K-Akt signaling pathway hsa04151
Ras signaling pathway hsa04014
Retrograde endocannabinoid signaling hsa04723
Serotonergic synapse hsa04726


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0020098-395  WD40
cl0256798-395  WD40 superfamily
cd00200229-394  WD40
cd0020095-267  WD40
pfam0040095-133  WD40
smart0032095-133  WD40
pfam00400357-394  WD40
smart00320356-394  WD40
pfam00400271-309  WD40
smart00320270-309  WD40
pfam00400227-267  WD40
smart00320226-267  WD40
pfam00400194-223  WD40
smart00320194-223  WD40
COG231996-394  WD40
COG231996-394  WD40
COG231996-372  WD40
COG231998-334  WD40
PLN00181256-394  PLN00181
PTZ00421207-317  PTZ00421
PLN00181150-354  PLN00181
PTZ00421334-393  PTZ00421
PTZ00421194-282  PTZ00421
COG2319333-394  WD40


Ontology Information


   
HPRD ID5659
Molecular ClassNot Available
Molecular FunctionLipid binding (GO:0008289)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO