Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GPAA1 | 8733 | glycosylphosphatidylinositol anchor attachment 1 | 8 | GAA1, hGAA1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24535878 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 52 Stage : - | MALDI-TOF/TOF-MS,immunohistochemistry,real time RT-PCR, co-immunoprecipitation, and Western blotting | Up-regulation | - | GPAA1 is highly expressed in patients with colorectal cancer, which indicates that it might play an important role in the proliferation, invasion, and metastasis of colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains. [provided by RefSeq, Jul 2008] | Chromosome | 8 |
| Location | 8q24.3 |
| Start | 145137064 |
| End | 145141119 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4056 |
| OMIM ID | 603048 |
| HGNC ID | HGNC:4446 |
| Unigene ID | Hs.627962 |
| Ensembl ID | ENSG00000197858 |
| PharmGKB ID | PA28827 |
Protein Information
| Protein ID | NP_003792.1 |
|---|---|
| Protein Name | glycosylphosphatidylinositol anchor attachment 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 621 |
| Uniprot ID | O00762 |
| Ensembl Protein ID | ENSP00000335674 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 107;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 54458 | PRR13 | 13211 | NP_001005355.1 | yeast 2-hybrid | 16169070 |
| 128869 | PIGU | 12250 | NP_536724.1 | in vivo | 14660601 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | hsa00563 |
| Metabolic pathways | hsa01100 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam04114 | 124-621 | Gaa1 |
| cl14876 | 124-621 | Zinc_peptidase_like superfamily |
Ontology Information
| HPRD ID | 3310 |
|---|---|
| Molecular Class | Anchor protein |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.