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General Information
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22799385 | 2012 | Cell line : - Source : Department of Gastrointestinal Surgery, Guangdong Provincial People's Hospital. Sample Type : CRC tumor and Normal tissue No. of Sample : 13 Stage : - | 2-D Gelelectrophoresis and MALDI-TOF mass spectrometry. | Up-regulation | - | This Gene differentially expressed and analysed by 2-D Gel Electrophoresis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 3 |
| Location | 3p21.3 |
| Start | 49357176 |
| End | 49358358 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 1183 |
| OMIM ID | 138320 |
| HGNC ID | HGNC:4553 |
| Unigene ID | Hs.76686 |
| Ensembl ID | ENSG00000233276 |
| PharmGKB ID | PA28949 |
mRNA Information
| mRNA ID | NM_000581.2 |
|---|---|
| Exon | join(1..332,612..1183) | mRNA Sequence | Download Select all |
| Length | 921 |
Protein Information
| Protein ID | NP_000572.2 |
|---|---|
| Protein Name | Glutathione peroxidase 1 |
| Molecular Wt. (Da) | 21957 |
| Protein Sequence | Download Select all |
| Length | 203 |
| Uniprot ID | P38398 |
| Ensembl Protein ID | ENSP00000312236 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 40 |
| Y | Phosphorylation | 98 |
| Y | Phosphorylation | 40 |
| Y | Phosphorylation | 98 |
Enzyme Information
| EC | 1.11.1.9 |
|---|---|
| Name | glutathione peroxidase GSH peroxidase selenium-glutathione peroxidase reduced glutathione peroxidase |
| Class | Oxidoreductases; Acting on a peroxide as acceptor; Peroxidases |
| Sysname | glutathione:hydrogen-peroxide oxidoreductase |
| Substrate | glutathione [CPD:C00051]; H2O2 |
| Product | glutathione disulfide [CPD:C00127]; H2O |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Amyotrophic lateral sclerosis (ALS) | hsa05014 |
| Arachidonic acid metabolism | hsa00590 |
| Glutathione metabolism | hsa00480 |
| Huntington's disease | hsa05016 |
| Thyroid hormone synthesis | hsa04918 |
Structure Information
| PDB ID | 2F8A |
|---|---|
| Resolution | 1.9 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B |
| Molecule | Glutathione peroxidase 1 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00340 | 15-192 | GSH_Peroxidase |
| cl00388 | 15-192 | Thioredoxin_like superfamily |
| pfam00255 | 16-130 | GSHPx |
| COG0386 | 14-198 | BtuE |
| PTZ00256 | 15-198 | PTZ00256 |
| PLN02412 | 14-198 | PLN02412 |
| PRK10606 | 27-180 | btuE |
| PTZ00056 | 15-196 | PTZ00056 |
| TIGR02540 | 15-196 | gpx7 |
| PLN02399 | 14-197 | PLN02399 |
| cd02966 | 18-75 | TlpA_like_family |
Ontology Information
| HPRD ID | 218 |
|---|---|
| Molecular Class | Enzyme: Peroxidase |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of gene expression, epigenetic (GO:0040029) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P07203 | DB00143 | Glutathione | SmallMoleculeDrug |