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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21997591 | 2012 | Cell line : - Source : Chang Gung Memorial Hospital (Taoyuan, Taiwan) Sample Type : CRC tumor and Normal tissue No. of Sample : 32 Stage : TNM Stage I-IV | Western blotting, Immunohistochemistry, ELISA | Up-regulation | - | Immunohistochemistry showed that secretory gelsolin was highly overexpressed in CRC tissue specimens compared to adjacent normal tissues, and a cell model study showed that secretory gelsolin may help regulate CRC cell migration. Significant increase of secretory gelsolin in plasma samples of stage IV versus stages I-III CRC patients before treatment. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. | Chromosome | 9 |
| Location | 9q33 |
| Start | 121210803 |
| End | 121332844 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 122042 |
| OMIM ID | 137350 |
| HGNC ID | HGNC:4620 |
| Unigene ID | Hs.522373 |
| Ensembl ID | ENSG00000148180 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011519287.1 |
|---|---|
| Exon | <1660..1737 | mRNA Sequence | Download Select all |
| Length | 2719 |
Protein Information
| Protein ID | NP_000168.1 |
|---|---|
| Protein Name | gelsolin |
| Molecular Wt. (Da) | 82959 |
| Protein Sequence | Download Select all |
| Length | 782 |
| Uniprot ID | P16104 |
| Ensembl Protein ID | ENSP00000364310 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Disulfide Bridge | 215;228 |
| Y | Phosphorylation | 358 |
| Y | Phosphorylation | 35 |
| Y | Phosphorylation | 414 |
| Y | Phosphorylation | 552 |
| Y | Phosphorylation | 600 |
| D | Proteolytic Cleavage | 403 |
| D | Proteolytic Cleavage | 352 |
| G | Myristoylation | 404 |
| K | Acetylation | 61 |
| K | Acetylation | 10 |
| S | Phosphorylation | 261 |
| S | Phosphorylation | 210 |
| T | Phosphorylation | 361 |
| T | Phosphorylation | 310 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 58 | ACTA1 | 30 | NP_001091.1 | in vitro | 10583954 |
| 60 | ACTB | 32 | NP_001092.1 | in vivo | 10945978 |
| 71 | ACTG1 | 17 | NP_001605.1 | in vitro | 784 901 711 733 011 |
| 351 | APP | 100 | NP_000475.1 | in vitro;in vivo | 10329371 |
| 2272 | FHIT | 3096 | NP_002003.1 | in vitro | 12833632 |
| 2335 | FN1 | 626 | NP_997647.1 | in vivo | 6092370 |
| 10040 | TOM1L1 | 5266 | NP_005477.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Fc gamma R-mediated phagocytosis | hsa04666 |
| Regulation of actin cytoskeleton | hsa04810 |
| Viral carcinogenesis | hsa05203 |
Structure Information
| PDB ID | 1C0F |
|---|---|
| Resolution | 2.4 |
| Method | X-RAY DIFFRACTION |
| Chains | S |
| Molecule | GELSOLIN SEGMENT 1 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11290 | 59-171 | gelsolin_S1_like |
| cl15697 | 59-171 | ADF_gelsolin superfamily |
| cd11293 | 439-539 | gelsolin_S4_like |
| cl15697 | 439-539 | ADF_gelsolin superfamily |
| cd11291 | 666-764 | gelsolin_S6_like |
| cl15697 | 666-764 | ADF_gelsolin superfamily |
| cd11289 | 186-275 | gelsolin_S2_like |
| cl15697 | 186-275 | ADF_gelsolin superfamily |
| cd11292 | 295-395 | gelsolin_S3_like |
| cl15697 | 295-395 | ADF_gelsolin superfamily |
| cd11288 | 561-649 | gelsolin_S5_like |
| cl15697 | 561-649 | ADF_gelsolin superfamily |
| cd11290 | 442-550 | gelsolin_S1_like |
| smart00262 | 188-277 | GEL |
| cd11293 | 68-161 | gelsolin_S4_like |
| smart00262 | 672-763 | GEL |
| smart00262 | 308-396 | GEL |
| smart00262 | 448-542 | GEL |
| smart00262 | 69-164 | GEL |
| pfam00626 | 196-271 | Gelsolin |
| smart00262 | 566-648 | GEL |
| cd11280 | 446-539 | gelsolin_like |
| cd11292 | 667-760 | gelsolin_S3_like |
| cd11280 | 666-760 | gelsolin_like |
| cd11280 | 562-645 | gelsolin_like |
| pfam00626 | 680-757 | Gelsolin |
| pfam00626 | 454-536 | Gelsolin |
| cd11291 | 299-396 | gelsolin_S6_like |
| cd11280 | 188-274 | gelsolin_like |
| pfam00626 | 75-158 | Gelsolin |
| pfam00626 | 320-390 | Gelsolin |
| cd11280 | 69-161 | gelsolin_like |
| cd11280 | 300-393 | gelsolin_like |
| cd11288 | 188-277 | gelsolin_S5_like |
| cd11289 | 563-646 | gelsolin_S2_like |
| pfam00626 | 576-642 | Gelsolin |
| cd11289 | 320-383 | gelsolin_S2_like |
| cd11288 | 298-389 | gelsolin_S5_like |
| cd11291 | 188-267 | gelsolin_S6_like |
| cd00013 | 562-636 | ADF_gelsolin |
| cd11289 | 666-763 | gelsolin_S2_like |
| cd11292 | 563-638 | gelsolin_S3_like |
| cd11293 | 305-393 | gelsolin_S4_like |
Ontology Information
| HPRD ID | 3143 |
|---|---|
| Molecular Class | Cytoskeletal protein |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.