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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
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- Pathway
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25778330 | 2015 | Cell line : SW480, SW480 CPT Source : - Sample Type : - No. of Sample : - Stage : - | Meta analysis | Polymorhpism | - | This meta-analysis suggested that GSTA1 BB genotype was a risk factor for colorectal cancer, especially in Caucasian populations. |
| 21355292 | 2011 | Cell line : - Source : A literature search of PubMed and Web of Science databases Sample Type : - No. of Sample : - Stage : - | Microarray, RT-PCR | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Glutathione S-transferases / Soluble |
| Description | This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] | Chromosome | 6 |
| Location | 6p12.2 |
| Start | 52656178 |
| End | 52668664 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 12487 |
| OMIM ID | 138359 |
| HGNC ID | HGNC:4626 |
| Unigene ID | Hs.446309 |
| Ensembl ID | ENSG00000243955 |
| PharmGKB ID | PA29016 |
mRNA Information
| mRNA ID | NM_145740.4 |
|---|---|
| Exon | join(1..82,4570..4686,6230..6281,7553..7685,9601..9742, 10880..11011,11887..12487) | mRNA Sequence | Download Select all |
| Length | 1377 |
Protein Information
| Protein ID | NP_665683.1 |
|---|---|
| Protein Name | glutathione S-transferase alpha 1 |
| Molecular Wt. (Da) | 25500 |
| Protein Sequence | Download Select all |
| Length | 222 |
| Uniprot ID | P26447 |
| Ensembl Protein ID | ENSP00000346294 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 142 |
| S | Phosphorylation | 202 |
| S | Phosphorylation | 37 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemical carcinogenesis | hsa05204 |
| Drug metabolism - cytochrome P450 | hsa00982 |
| Glutathione metabolism | hsa00480 |
| Metabolism of xenobiotics by cytochrome P450 | hsa00980 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03208 | 86-220 | GST_C_Alpha |
| cl02776 | 86-220 | GST_C_family superfamily |
| cd03077 | Apr-82 | GST_N_Alpha |
| cl00388 | Apr-82 | Thioredoxin_like superfamily |
| cd03039 | May-76 | GST_N_Sigma_like |
| cd03192 | 88-188 | GST_C_Sigma_like |
| pfam00043 | 99-192 | GST_C |
| pfam02798 | May-77 | GST_N |
| cd03210 | 86-207 | GST_C_Pi |
| cd00570 | May-76 | GST_N_family |
| cd03076 | Apr-78 | GST_N_Pi |
| cd03075 | May-79 | GST_N_Mu |
| cd03209 | 87-207 | GST_C_Mu |
| cd03191 | 118-196 | GST_C_Zeta |
| cd03046 | May-79 | GST_N_GTT1_like |
| cd00299 | 89-188 | GST_C_family |
| cd10293 | 130-196 | GST_C_Ure2p |
| cd03181 | 88-198 | GST_C_EF1Bgamma_like |
| cd03056 | Jun-76 | GST_N_4 |
| cd03188 | 114-198 | GST_C_Beta |
| cd03053 | 23-78 | GST_N_Phi |
| cd02976 | 17-66 | NrdH |
| cd03178 | 137-196 | GST_C_Ure2p_like |
| PTZ00057 | 1-198 | PTZ00057 |
| COG0625 | 5-197 | GstA |
| TIGR01262 | 53-207 | maiA |
| PLN02473 | 27-199 | PLN02473 |
| PLN02395 | 23-199 | PLN02395 |
Ontology Information
| HPRD ID | 237 |
|---|---|
| Molecular Class | Enzyme: Glutathione transferase |
| Molecular Function | Calcium ion binding (GO:0005509) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P08263 | DB00143 | Glutathione | SmallMoleculeDrug |
| P08263 | DB00993 | Azathioprine | SmallMoleculeDrug |
| P08263 | DB01008 | Busulfan | SmallMoleculeDrug |
| P08263 | DB00143 | Glutathione | SmallMoleculeDrug |