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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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- Pathway
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26219826 | 2015 | Cell line : - Source : PubMed database and Asian populations Sample Type : Population basedcCase control study. No. of Sample : 33 case-control studies in Asian populations 8502 CRC and 13699 controls Stage : - | Meta analysis | Polymorhpism | - | Meta-analysis suggested that GSTM1 null polymorphism confer the susceptibility to colorectal cancer in Asians, especially in Chinese populations. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Glutathione S-transferases / Soluble |
| Description | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008] | Chromosome | 1 |
| Location | 1p13.3 |
| Start | 110230418 |
| End | 110240828 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 10411 |
| OMIM ID | 138350 |
| HGNC ID | HGNC:4632 |
| Unigene ID | Hs.301961 |
| Ensembl ID | ENSG00000134184 |
| PharmGKB ID | PA182 |
mRNA Information
| mRNA ID | NM_000561.3 |
|---|---|
| Exon | join(1..114,375..450,878..942,1253..1334,1430..1530, 2476..2571,2659..2769,5411..5950) | mRNA Sequence | Download Select all |
| Length | 1266 |
Protein Information
| Protein ID | NP_000552.2 |
|---|---|
| Protein Name | glutathione S-transferase mu 1 |
| Molecular Wt. (Da) | 25581 |
| Protein Sequence | Download Select all |
| Length | 218 |
| Uniprot ID | P05109 |
| Ensembl Protein ID | ENSP00000357721 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 126 |
| K | Acetylation | 126 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemical carcinogenesis | hsa05204 |
| Drug metabolism - cytochrome P450 | hsa00982 |
| Glutathione metabolism | hsa00480 |
| Metabolism of xenobiotics by cytochrome P450 | hsa00980 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03209 | 92-212 | GST_C_Mu |
| cl02776 | 92-212 | GST_C_family superfamily |
| cd03075 | Mar-84 | GST_N_Mu |
| cl00388 | Mar-84 | Thioredoxin_like superfamily |
| cd03039 | Mar-82 | GST_N_Sigma_like |
| pfam02798 | Mar-82 | GST_N |
| pfam00043 | 105-192 | GST_C |
| cd03192 | 92-188 | GST_C_Sigma_like |
| cd03210 | 91-208 | GST_C_Pi |
| cd00570 | Mar-81 | GST_N_family |
| cd03076 | Feb-83 | GST_N_Pi |
| cd00299 | 118-187 | GST_C_family |
| cd10295 | 91-181 | GST_C_Sigma |
| cd03184 | 128-187 | GST_C_Omega |
| pfam14497 | 129-189 | GST_C_3 |
| cd03188 | 121-187 | GST_C_Beta |
| cd03077 | Apr-86 | GST_N_Alpha |
| cd03193 | 127-188 | GST_C_Metaxin |
| pfam13417 | 14-84 | GST_N_3 |
| cd03207 | 109-187 | GST_C_8 |
| cd03183 | 121-199 | GST_C_Theta |
| cd03046 | 14-84 | GST_N_GTT1_like |
| COG0625 | 3-189 | GstA |
| PTZ00057 | 3-203 | PTZ00057 |
| PLN02395 | 57-178 | PLN02395 |
Ontology Information
| HPRD ID | 472 |
|---|---|
| Molecular Class | Enzyme: Glutathione transferase |
| Molecular Function | Calcium ion binding (GO:0005509) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P09488 | DB00515 | Cisplatin | SmallMoleculeDrug |
| P09488 | DB00526 | Oxaliplatin | SmallMoleculeDrug |
| P09488 | DB00958 | Carboplatin | SmallMoleculeDrug |
| P09488 | DB00993 | Azathioprine | SmallMoleculeDrug |
| P09488 | DB01008 | Busulfan | SmallMoleculeDrug |
| P09488 | DB00143 | Glutathione | SmallMoleculeDrug |