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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25408579 | 2014 | Cell line : - Source : Shandong Cancer Hospital and Institute. Sample Type : CRC tumor and normal tissue No. of Sample : 264 cases and 317 controls Stage : - | Genotyping | Polymorhpism | - | GSTT1 and GSTM1 polymorphisms, but not GSTP1, may modulate the CRC risk among Chinese. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Glutathione S-transferases / Soluble |
| Description | The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015] | Chromosome | 22 |
| Location | 22q11.23 a |
| Start | 24376135 |
| End | 24384284 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 8150 |
| OMIM ID | 600436 |
| HGNC ID | HGNC:4641 |
| Unigene ID | Hs.268573 |
| Ensembl ID | ENSG00000277656 |
| PharmGKB ID | PA183 |
mRNA Information
| mRNA ID | NM_001293814.1 |
|---|---|
| Exon | join(1..192,7695..8179) | mRNA Sequence | Download Select all |
| Length | 693 |
Protein Information
| Protein ID | NP_001280743.1 |
|---|---|
| Protein Name | glutathione S-transferase theta 1 |
| Molecular Wt. (Da) | 7575 |
| Protein Sequence | Download Select all |
| Length | 72 |
| Uniprot ID | P60903 |
| Ensembl Protein ID | ENSP00000357799 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemical carcinogenesis | hsa05204 |
| Drug metabolism - cytochrome P450 | hsa00982 |
| Glutathione metabolism | hsa00480 |
| Metabolism of xenobiotics by cytochrome P450 | hsa00980 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03183 | 91-216 | GST_C_Theta |
| cl02776 | 91-216 | GST_C_family superfamily |
| cd03050 | Mar-78 | GST_N_Theta |
| cl00388 | Mar-78 | Thioredoxin_like superfamily |
| cd03045 | Mar-74 | GST_N_Delta_Epsilon |
| cd00570 | Mar-74 | GST_N_family |
| cd03042 | 26-74 | GST_N_Zeta |
| cd03046 | 25-78 | GST_N_GTT1_like |
| cd03056 | Mar-74 | GST_N_4 |
| cd03053 | Mar-77 | GST_N_Phi |
| cd03048 | 17-78 | GST_N_Ure2p_like |
| cd03057 | 25-74 | GST_N_Beta |
| pfam02798 | Oct-76 | GST_N |
| cd03051 | 15-74 | GST_N_GTT2_like |
| cd03177 | 90-212 | GST_C_Delta_Epsilon |
| pfam13417 | May-74 | GST_N_3 |
| cd03044 | 13-77 | GST_N_EF1Bgamma |
| pfam13409 | 14-74 | GST_N_2 |
| cd03043 | 21-74 | GST_N_1 |
| cd03047 | 43-74 | GST_N_2 |
| cd03180 | 90-169 | GST_C_2 |
| pfam00043 | 111-200 | GST_C |
| cd00299 | 95-198 | GST_C_family |
| cd03059 | Aug-78 | GST_N_SspA |
| cd03039 | 50-76 | GST_N_Sigma_like |
| cd03182 | 149-200 | GST_C_GTT2_like |
| cd03054 | Oct-77 | GST_N_Metaxin |
| cd03181 | 119-177 | GST_C_EF1Bgamma_like |
| cd03076 | 14-77 | GST_N_Pi |
| cd03188 | 91-200 | GST_C_Beta |
| COG0625 | 3-212 | GstA |
| PRK15113 | 3-138 | PRK15113 |
| PLN02395 | 1-194 | PLN02395 |
| TIGR01262 | 26-95 | maiA |
| PLN02473 | 13-168 | PLN02473 |
| PRK10542 | 16-200 | PRK10542 |
| PRK11752 | 32-102 | PRK11752 |
| PRK13972 | 17-168 | PRK13972 |
Ontology Information
| HPRD ID | 4385 |
|---|---|
| Molecular Class | Enzyme: Glutathione transferase |
| Molecular Function | Calcium ion binding (GO:0005509) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P30711 | DB00515 | Cisplatin | SmallMoleculeDrug |
| P30711 | DB00526 | Oxaliplatin | SmallMoleculeDrug |
| P30711 | DB00773 | Etoposide | SmallMoleculeDrug |
| P30711 | DB00958 | Carboplatin | SmallMoleculeDrug |
| P30711 | DB00143 | Glutathione | SmallMoleculeDrug |