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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24195516 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 99 Stage : - | Immunohistochemistry, methylation-specific PCR | Methylation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014] | Chromosome | 7 |
| Location | 7q11.21 |
| Start | 65425671 |
| End | 65447301 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 21631 |
| OMIM ID | 611499 |
| HGNC ID | HGNC:4696 |
| Unigene ID | Hs.255230 |
| Ensembl ID | ENSG00000169919 |
| PharmGKB ID | PA29075 |
mRNA Information
| mRNA ID | NM_001293105.1 |
|---|---|
| Exon | join(1..341,1906..2091,6113..6300,7244..7396,7611..7789, 7874..8020,11949..12033,14408..14584,17857..17992, 21252..21631) | mRNA Sequence | Download Select all |
| Length | 1985 |
Protein Information
| Protein ID | NP_001280034.1 |
|---|---|
| Protein Name | glucuronidase, beta |
| Molecular Wt. (Da) | 49501 |
| Protein Sequence | Download Select all |
| Length | 432 |
| Uniprot ID | P04271 |
| Ensembl Protein ID | ENSP00000291700 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 173 |
| N | Glycosylation | 272 |
| T | Phosphorylation | 274 |
| N | Glycosylation | 420 |
| N | Glycosylation | 631 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1066 | CES1 | 268 | NP_001020366.1 | in vitro;in vivo | 10562416 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Drug metabolism - other enzymes | hsa00983 |
| Glycosaminoglycan degradation | hsa00531 |
| Lysosome | hsa04142 |
| Metabolic pathways | hsa01100 |
| Pentose and glucuronate interconversions | hsa00040 |
| Porphyrin and chlorophyll metabolism | hsa00860 |
| Starch and sucrose metabolism | hsa00500 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02836 | 329-631 | Glyco_hydro_2_C |
| cl22871 | 329-631 | Glyco_hydro_2_C superfamily |
| pfam02837 | 35-224 | Glyco_hydro_2_N |
| cl18398 | 35-224 | Glyco_hydro_2_N superfamily |
| pfam00703 | 226-327 | Glyco_hydro_2 |
| cl12242 | 226-327 | Glyco_hydro_2 superfamily |
| pfam12876 | 433-480 | Cellulase-like |
| PRK10150 | 27-631 | PRK10150 |
| COG3250 | 27-641 | LacZ |
| PRK10340 | 101-542 | ebgA |
| PRK09525 | 31-479 | lacZ |
Ontology Information
| HPRD ID | 2792 |
|---|---|
| Molecular Class | Enzyme: Hydrolase |
| Molecular Function | Calcium ion binding (GO:0005509) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.