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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GZMB | 3002 | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 14 | CCPI, CGL-1, CSP-B, CGL1, CTSGL1, HLP, SECT |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21884199 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 963 Stage : - | Immunohistochemistry | Down-regulation | - | Low expression of Granzyme B was associated with early signs of metastasis in CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008] | Chromosome | 14 |
| Location | 14q11.2 |
| Start | 25100160 |
| End | 25103490 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 3331 |
| OMIM ID | 123910 |
| HGNC ID | HGNC:4709 |
| Unigene ID | Hs.1051 |
| Ensembl ID | ENSG00000100453 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011536685.1 |
|---|---|
| Exon | join(28..121,1152..1312,1768..1903,2109..2369,3013..3279) | mRNA Sequence | Download Select all |
| Length | 919 |
Protein Information
| Protein ID | XP_011534987.1 |
|---|---|
| Protein Name | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
| Molecular Wt. (Da) | 26286 |
| Protein Sequence | Download Select all |
| Length | 235 |
| Uniprot ID | P25815 |
| Ensembl Protein ID | ENSP00000296370 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 142 | PARP1 | 1435 | NP_001609.2 | in vitro | 9586635 |
| 637 | BID | 3590 | NP_932070.1 | in vivo | 972 749 111 085 743 |
| 836 | CASP3 | 2799 | NP_004337.2 | in vitro;in vivo | 92 337 639 694 885 |
| 840 | CASP7 | 3457 | NP_203124.1 | in vitro | 8631895 |
| 842 | CASP9 | 3756 | NP_001220.2 | in vitro | 890 020 110 671 559 000 000 |
| 1131 | CHRM3 | 329 | NP_000731.1 | in vitro;in vivo | 11665980 |
| 1676 | DFFA | 3531 | NP_004392.1 | in vitro;in vivo | 11406587 |
| 2892 | GRIA3 | 2378 | NP_000819.3 | in vivo | 11160179 |
| 4001 | LMNB1 | 1036 | NP_005564.1 | in vitro | 11331782 |
| 5591 | PRKDC | 2941 | NP_008835.5 | in vitro | 9586635 |
| 5747 | PTK2 | 2859 | NP_005598.3 | in vitro | 9642276 |
| 7518 | XRCC4 | 15951 | NP_071801.1 | in vivo | 12218164 |
| 9354 | UBE4A | 6793 | NP_004779.2 | in vitro | 11802788 |
| 10277 | UBE4B | 11659 | AAD02233.1 | in vitro | 11802788 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Allograft rejection | hsa05330 |
| Autoimmune thyroid disease | hsa05320 |
| Graft-versus-host disease | hsa05332 |
| Natural killer cell mediated cytotoxicity | hsa04650 |
| Transcriptional misregulation in cancer | hsa05202 |
| Type I diabetes mellitus | hsa04940 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00190 | 21-243 | Tryp_SPc |
| cl21584 | 21-243 | Tryp_SPc superfamily |
| smart00020 | 20-240 | Tryp_SPc |
| pfam00089 | 21-240 | Trypsin |
| COG5640 | 16-245 | COG5640 |
Ontology Information
| HPRD ID | 97 |
|---|---|
| Molecular Class | Serine protease |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Lipid transport (GO:0006869); Inflammatory response (GO:0006954) |
Drug Information
No matching records could be found.