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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23951239 | 2013 | Cell line : - Source : The national Danish HNPCC register Sample Type : - No. of Sample : - Stage : TNM Stage I-III | real time RT-PCR,whole-genome c-DNA-mediated annealing, selection, extension, and ligation assay,Gene Expression Profiling | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Histones / Replication-independent |
| Description | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008] | Chromosome | 4 |
| Location | 4q23 |
| Start | 100869242 |
| End | 100871512 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 2271 |
| OMIM ID | 142763 |
| HGNC ID | HGNC:4741 |
| Unigene ID | Hs.119192 |
| Ensembl ID | ENSG00000164032 |
| PharmGKB ID | PA29119 |
mRNA Information
| mRNA ID | NM_002106.3 |
|---|---|
| Exon | join(1..188,616..693,970..1083,1416..1545,1833..2269) | mRNA Sequence | Download Select all |
| Length | 951 |
Protein Information
| Protein ID | NP_002097.1 |
|---|---|
| Protein Name | H2A histone family, member Z |
| Molecular Wt. (Da) | 13422 |
| Protein Sequence | Download Select all |
| Length | 128 |
| Uniprot ID | Q01826 |
| Ensembl Protein ID | ENSP00000341024 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 5 |
| K | Acetylation | 8 |
| K | Acetylation | 12 |
| K | Acetylation | 14 |
| K | Acetylation | 116 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Alcoholism | hsa05034 |
| Systemic lupus erythematosus | hsa05322 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00074 | 8-122 | H2A |
| cl00074 | 8-122 | H2A superfamily |
| PLN00154 | 6-121 | PLN00154 |
| smart00414 | 19-124 | H2A |
| COG5262 | 1-122 | HTA1 |
| pfam00125 | 20-94 | Histone |
| PTZ00252 | 12-126 | PTZ00252 |
| PLN00155 | Jan-62 | PLN00155 |
| COG5247 | 27-100 | BUR6 |
| PTZ00017 | 3-128 | PTZ00017 |
| PLN00157 | 3-127 | PLN00157 |
| PLN00156 | 1-125 | PLN00156 |
| PLN00153 | 1-122 | PLN00153 |
Ontology Information
| HPRD ID | 8355 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Voltage-gated ion channel activity (GO:0005244) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.