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General Information
- Evidence
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 14566823 | 2003 | Cell line : SW480 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Transfection of SW620 cells with asHAS cDNA,Cell viability,Cell proliferation,Cell growth in soft agar | Up-regulation | - | HAS3 function in the growth and progression of colon carcinoma. |
| 15065603 | 2004 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 31 Stage : Duke Stage A-D | real time RT-PCR | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Glycosyltransferase family 2 domain containing |
| Description | The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010] | Chromosome | 16 |
| Location | 16q22.1 |
| Start | 69139467 |
| End | 69152622 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 13156 |
| OMIM ID | 602428 |
| HGNC ID | HGNC:4820 |
| Unigene ID | Hs.592069 |
| Ensembl ID | ENSG00000103044 |
| PharmGKB ID | PA29196 |
mRNA Information
| mRNA ID | NM_001199280.1 |
|---|---|
| Exon | join(1..224,3833..4468,7878..7979,8780..12105) | mRNA Sequence | Download Select all |
| Length | 4288 |
Protein Information
| Protein ID | NP_001186209.1 |
|---|---|
| Protein Name | hyaluronan synthase 3 |
| Molecular Wt. (Da) | 62867 |
| Protein Sequence | Download Select all |
| Length | 553 |
| Uniprot ID | P13500 |
| Ensembl Protein ID | ENSP00000225831 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06434 | 86-364 | GT2_HAS |
| cl11394 | 86-364 | Glyco_tranf_GTA_type superfamily |
| cd06423 | 91-297 | CESA_like |
| cd04190 | 186-360 | Chitin_synth_C |
| cd06439 | 86-347 | CESA_like_1 |
| cd06421 | 86-363 | CESA_CelA_like |
| pfam00535 | 90-299 | Glycos_transf_2 |
| pfam13632 | 210-419 | Glyco_trans_2_3 |
| cd00761 | 91-243 | Glyco_tranf_GTA_type |
| cd06427 | 323-366 | CESA_like_2 |
| cd04191 | 205-239 | Glucan_BSP_ModH |
| cd06436 | 211-280 | GlcNAc-1-P_transferase |
| COG1215 | 47-478 | BcsA |
| TIGR04242 | 86-466 | nodulat_NodC |
| pfam03142 | 91-360 | Chitin_synth_2 |
| pfam13641 | 86-360 | Glyco_tranf_2_3 |
| COG1216 | 203-434 | GT2 |
| TIGR03937 | 209-297 | PgaC_IcaA |
| PRK11204 | 209-430 | PRK11204 |
Ontology Information
| HPRD ID | 1751 |
|---|---|
| Molecular Class | Enzyme: Synthase |
| Molecular Function | Chemokine activity (GO:0008009) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.