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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HAX1 | 10456 | HCLS1 associated protein X-1 | 1 | HS1BP1, HCLSBP1 |
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24057929 | 2014 | Cell line : - Source : General Hospital of Beijing Military Region, China. Sample Type : CRC tumor and normal tissue No. of Sample : 189 Stage : - | Immunohistochemistry (IHC) and qRT-qPCR | Up-regulation | - | HAX-1 might be an important marker for tumor progression and prognosis, as well as a potential therapeutic target of CRC. |
| 26062578 | 2015 | Cell line : SW480 CRC cells. Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 60 Stage : - | - | Up-regulation | - | The expression levels of HAX?1 were significantly higher in the cancerous tissues from the patients with CRC, particularly in tissues of an advanced stage of cancer, HAX?1 may contribute to chemotherapy resistance and malignant progression in CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 1 |
| Location | 1q21.3 |
| Start | 154245039 |
| End | 154248351 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3313 |
| OMIM ID | 605998 |
| HGNC ID | HGNC:16915 |
| Unigene ID | Hs.199625 |
| Ensembl ID | ENSG00000143575 |
| PharmGKB ID | PA142671700 |
Protein Information
| Protein ID | NP_001018238.1 |
|---|---|
| Protein Name | HCLS1 associated protein X-1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 279 |
| Uniprot ID | Q9Y689 |
| Ensembl Protein ID | ENSP00000295087 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2017 | CTTN | 1268 | NP_005222.2 | in vitro | 15159385 |
| 3059 | HCLS1 | 3199 | NP_005326.2 | in vitro;yeast 2-hybrid | 9058808 |
| 3552 | IL1A | 988 | NP_000566.3 | in vitro;in vivo | 11554782 |
| 5243 | ABCB1 | 1370 | NP_000918.2 | in vivo;yeast 2-hybrid | 15159385 |
| 5244 | ABCB4 | 1371 | NP_061337.1 | in vitro;in vivo;yeast 2-hybrid | 15159385 |
| 5311 | PKD2 | 1437 | NP_000288.1 | in vivo;yeast 2-hybrid | 10760273 |
| 8647 | ABCB11 | 4436 | NP_003733.2 | in vitro;in vivo;yeast 2-hybrid | 15159385 |
| 10971 | YWHAQ | 886 | NP_006817.1 | in vitro;yeast 2-hybrid | 9058808 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 7277 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.