CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
16309230	2005	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 40 Stage : -	RT-PCR	Up-regulation	-
17720775	2007	Cell line : - Source : Yamagata Prefectural Central Hospital. Sample Type : CRC tumor and normal tissue No. of Sample : 64 Stage : -	Immunohistochemistry, In situ hybridisation (ISH) and RT-PCR	Up-regulation	-	Tissue samples were obtained from 64 patients with colorectal carcinoma who underwent surgical resection.
18347167	2008	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 40 Stage : -	Immunohistochemistry	Up-regulation	-	The strong prognostic impact of HDAC isoforms in colorectal cancer, the interactions of HDACs with tumor cell proliferation and differentiation in vivo.
18789002	2009	Cell line : SW480, SW620, KM12C, KM12L4, HT29, HCT116, Colo201, Colo205 and Ls174T Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 18 Stage : -	RT-PCR, Western blotting, Flow cytometry	Up-regulation	-	HDAC1 and HDAC3 are up-regulated in colon cancer cells and in primary colon cancer. These studies show that cancer cells effectively maintain low levels of pyruvate to prevent inhibition of HDAC1/HDAC3 and thereby to evade cell death.
21151932	2010	Cell line : - Source : Fatebenefratelli Hospital in Benevento. Sample Type : - No. of Sample : - Stage : -	Western blotting, immunohistochemistry, methylation specific -PCR and bisulphite sequencing.	Up-regulation	-	Transcriptional silencing is due to the recruitment of MeCP2, HDAC1 and EZH2 that impart repressive chromatin signatures determining an increased cell proliferative and invasive potentia and epigenetic silencing of PPARG in CRC that may be relevant as a prognostic marker of tumor progression.

Gene Details

Chromosome: 1; NC_000001.10 (32757708..32799224)
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Gene Type	protein coding
Gene Family	-
Description	Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]
Chromosome	1
Location	1p34
Start	32292107
End	32333628
Strand	+
Gene Sequence	>gi|568815597:32292107-32333628 Homo sapiens chromosome 1, GRCh38.p2 Primary Assembly GAGCGGAGCCGCGGGCGGGAGGGCGGACGGACCGACTGACGGTAGGGACGGGAGGCGAGCAAGATGGCGC AGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGTGAGCACCGTCCTCGCGGCGGGGGCGG GGCCAGGCCGGGCCGGACCGGGAACCTGGAGGCTGAGGCTGGAGCGCCGATGGGAGGCTGCGGGAGGCTG AGGCGCTGGGGAGAGGCTCGGAGAGGAGGCTGCGAGGGGGAAGTCGAGGCTGAGGGAGGAGGCTGCGAGG AAGGGAGATCGAGGCTGAGACCAAGAGGGGATCGCGTGGGGGAAGCGTGAGGTAATCTTGATGGGAAGAT TCTGAGGAAGTCTGATGTGGAGAGTTTGAGTGGGACTCCTAGAGGGGAGGGTGCGTCGGAGCGGGGAGGC TGAATCTGATGGAGACGGCTGCAAGGATACATTTTCTTGCCGAGAACCCAAAGCTCTTCCCTGCCCCGTC CCTTCCTCATCTTTTCTGGGGGAAGAGTCCTGCACGACTGGTTGCCCGCCTCCCCTCCCCCAGCCTCTGA GCGGGGCCTGCGGTTGCTACTGCGACGTGGGGCGCCAGGGGTTGCAAGGAGAAGGATGCAACCTGTTAAA ACAGACTTCTCACTTAATCTCTCAAGCAGGTTACTGTGTTCGAGGAAGTGTTGAGGGGCTGGGGCCGTGG GGTTGATCGGGTCACCCTTCCCAGTGACCGAAGTTCTCTCCGTGTCAGAGCTCAGAGTGTTAGGGGAGCA CAGAGAAGAGGCACCGAACTCCACCTGAGGAGTCAGCGAAGGAGGGGACATCTTAGTTAGGACCTGAAGA ACAGGAGTTCTTAGCCAGGCACAGGGAAGGCAAAGATAACAGCAAGTTTCAGAGGCAAGAGAGAGGACAG GACCTTTGAAAAACAGGCATTTGGCCGGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCC GAGGCTGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTA CTAAAAATACAAAATTAGCCGCGCATGGTGGTGTGCGCCTGTAATCCCAGCTACTCTGGAGCCTAAGGCA GGAGAATCCCTTAGAACCCGGGAGGCAGAGGTTGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCTTG GACAACAGAGCGAGGCTCTGTCTTAAAAAAAAAAAAAAAAAAAGATGTAAATAGGGACCGGACCATGAAG GGCTGGGCATGCTGTCCCAAGGAAGTTGGACTTTATTGAGGGCACTTGTGAGTGATTCAAGTTTTATGCA GGTTATTGACATCATCAGGTTTATACCTTAGAAATTAAAGTAATGGGGGCCAGGTGCAGTGGCTCACACC TCTCTAATCCCAGTACTTTGGGAGGCTGAGGCAGGCAGATCACTCGGGGCCAGGAGTTCAGGACCAGCCT GGCCAACACGGTGAAACCCCATCTCTACTAAAAATACAAAATTTAGGCTGGGCACGGTGGCTCACGCCTG TAATCCCGGCACTTTGGGAGGCTGAGGCGGGCGGATCATGAGGTCAGGAGTTCAAGACCAGCCTGACCAA CATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTACCCGGGTGTGGTGGTGCGCACCTGTAATCCC AGCTACTCAGGAGGCTGAGGCAGGAGAGTCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATT GCACCGCTGCACTCCAGCCTGGGCAACAGGGTGAGACTCCATCTCAAAAAAAAAAAAAAAAATTAGCGAG GTGTGGTGGCACATGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTGCGAGAGTTGTTTGAACCTGGGA GGCAGAGGTTGCAGTGGGCTGAGATCTCACCACTGCACTCCGTCCTGGGCAACAGAGCGAGACTTCGTCT CAAAAAAAAAAAAAACAAAAAAATTCAGATTGTAGGGGTAAGGAAGAAGGCATGGATCCCAAGTTCCTGG TGTGGGCAGTATTTTTTATTTTTTGAGATGATGTCTAGCTCTGTCACCCAGGCTGGAGTGCAGTGGCTTG ATCTCGGCTCACTGCAACTGCAACCTCCACCTCCCAGATTCAAGGGATTCTCCTGCCTCAGCCTCCTGAG TAGCTGGGATTACAGGCGTGCGCCACCATGCCTGGCTAGTTTTTGTATTTTTATTAGAGATGGGGTTTCA CGATGTTGGCCAGGCTGGTCTCAAACTGACCTCCAGTGCTCCATCTGCCTCAGCCTCCCAAAGTGCTGGG ATTATAGGCATGAGCCACACTTCCTGGCCTCTGATGTGGGCAATTTGATGGTGAGTGTTTGGAGGTTTGG AGAATGCCATGTCAGTTGATAACTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTCGCCCAG GCTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCTGCAAGCTCCACCTCCCGGGTCCATGCCATTCTCCT GCCTCAGCCTCTCCAGTAGCTGGGACTACAGGCGCCCGCCACCACACTGGGCTGATTTTTTGTATTTTTA GTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTGGATCTCCTGACCTCATGATCCGCCCGCCTCG GCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCACCCGGCCCCAACTTTTTTTTTTTTTTTTTA AACTTCTAGAGATGGGGTCTCAATATGTTGCCTGGGCTTGTCTTGAACTCCTGTGCCTGGCCTCAAGCAA TCCTGCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCCTAAGCCACTGTTTTTTTTGTTGTTGTTGT TTGTTTGTTTAGAAATAACTATTGATAACTGTTAAGATGTTTAGGGGACATCCAAGTAGAGGCATCCAGT AGGCAGTTTAGAAGATAGAAATTTTTTGGTAGTCATCAGTATCTTAGTCTGCTATAACAGAACACTGTTT ATAAAGAACAGAAATTGCTGAATGTGGTGGCTCACGCCTATAATCCCAGTACTTTGGTAGGCTGGGGCGG ATGGTTCTCTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACTTAGGGAGACTCTGTCTCTACAAAAAG TAAAAAAATTAGCTGGGCATGATGGCATGTGCCTGTAGAGAGGCTGAAGTGGGAGGATCACTTGATCCTG GGAGGTCGACTCTGCAGTGAGCCATGATCGCACCAGTGCACTCCAGCCTGGGGGACAGAGTGAGACCTTG TGTCAAAAAAAAAAAAAGAACATAAATGTATTTCTCATAGTTCTGGAGGCTGAGAAGTCCAAGGCTAGAA AGTCCAAGATCAGGGTGCCAGCATTTGGTGTCTGGTGAGGGTCTGGTCTCTACTTCCAATATGGTGCTTT GAATTCAGTGTTTTCATATGACAGAAGGTGGAAAGGCAAAAAAGGATAAACTCTGTTTTTTTATATGGCC ATTAATGTATTAGTGAGGATGGTAGAGCCCTTGAGACCTAAACACCTCCCAAAAGGCTCCACTTCCAAAC ACTGTTGGCATTGGGGAATATGTTTCCAACACATGAATTTTGGGGGACACATTCAGACCATAACAATCAG CATATGGATAGTTATTTTATTTGTTTGTTTGTTTGTTTGTTTGTTGTAGAGATGTTGTCTTGCCATGTTG TCCAGGCTGGCCTTGAAGTCCTGGGCTCAGCCTCCCAAAGTGTTGGGATTATAGGCATGACCCACCATTC CTGGCTGCTAGCAATTTTAATTGTAGTAAATTTAGTCATAAAGGATGCAGTCACCCAATAAGTTATATAG AATTCCAGGGTGGAATTCTAAGGAAGTGGATTGAGGAAAAGTTTAGTGCCCCTCATGCTGTGTACTCCCC CGTGATAGTATTTGTCACTGTGTAGAGGAATTGCCCATTTACTTGGTCATATTTCTTGTAGAGAGGAGGC TCTTTAGGGAAAGGGGCCGTGCCTTGTCTACCTCTGTATCCCCAGCACCAAAAACAATGCCTAGCTCATG GTAGGTTCTCAATAAATATTTGTTGATTAAATGTATAATGATAGAGAGTGAGGGGCCGGAGAGGTAGGTG AACCAGAAAGTACTGGGTTGCAGAAGCTAAAGAAGGGAGGGATTGGGCAAGTGTTGGCGGCAACTGGGGC AGAAGCTAGATTGTGGTAGATTGCAGTACATGGATGGCTAACTGAAGAGGAGACATCAGGTTGAACCCTT TTTTTGGAGACAGGGCCTCACTCTGTCACTCAGGCTGGAGTGCAGTGGCATGATCCTGGCTCACTACCAC CTCTGCCTCCCAGGCTCAAGCAGTCCTCCCACCTCAGCCTTCCAAGTAGCTGGAACCACAGGTGTGCACC CTTTTTGTATTTTTTGTTTAGAAGACAAACGGTTGTCTTTTGTTTAGAGACAGGATTTCGCCATGTTGCC CAGGCTGGTCTCAAACTCCTGAGCTCAAGTCATCTACCCGCCTCAGCCTCCCAAAGTGCTGGGTTTACAG GCGTGAGCCATCATGCCCAGCTGGTTGAACCCTTTTAAAGGGAAGCTTGTGTGAGGTAGGGAGAGAGGAT TGTTGATAAGGGAGATGGAGATGTAGTGGCTAAAAGTTGAGCATATTGAAATAATTCTTATGGAAAATAG CCAGAAGAGAGGGAGAGGCTGAAGATACAGGAAAGGGACTAGTAGTGATGGAGCTTCCTGAGGAGACCAG GGGAGATGGAAACCGGAGCCCAGCTAGAGACACTAACCTTCAACAAATTCCTTTGTGATGCGAGGGTAAA TGTCAAGGAAAAGTTCAAATGGAGGTAAGTTTGAAGAGGAGAAGATAAGGAGAAAGTTGAGGGAGTTCTC AAGATCAGGAAAGAGAATATTCCTTTTCCTGAGGGTGGGGTAGGGCAGTTGGTGGAGCAGGAATCTTGAA GAGAGGAGATTTAAATAGCTTTTGCAAAAGTGGGGGGCTAGGGAAAGAAATTTGGAAGGATTGCTGGCAG TGATAAGAATCATTTTGAGGCTGGAACCTGTGATTTTTGTAGTCATATCATTTTGCACAGTTTTATGATA ACATTTTATGATAACATTGTCAGTTTAAAAGAAGAAAAAAATGGGCTGGGCATGGTGGTTCACGCCTGTA ATCCCAGTAGTTTGGGAGGCCAAGGCGGAAGGATCACTTGAGACCAGGCGTTCAAGACCAGCCTGGGCAA CAAAATGAGACCTCCCCCAGCTCTACAAAACAACACAAAAAAATAAGCTGGGTGTGGTGGCACTTGCCTG TAATCGCAGCTACTTGGGAGGTTGAGGTGGGAGACTGAGGCAGGTGGATGGTTTGAGCCCAGGTGGAGCC TGCAGTGACCCATAATGGCACCACTGCACTCAGCTTGAGTGACAAAGCAAGACCCTGCCTCAAAAAAAGA AAAAGAAAAAGTACAAAGACCTCAGTCTTTAGATAAGGGAATAGACTTCTTTTTTTGCGGGGGGGACGGA GTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCCATCTCGGCTCACTGCAAGCTCTGCCTCCAGGG TTCATGCCATTCTCCTGCCTCAGCCTCCCGAGGAGCTGGGACTGGAGGCGCATGACACTACGCCTGGCTA ATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTTTCACCCAGGCTGGAGCGCAG TGGCGCGATCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGA GTAACTGGTACTACAGGCGCCTACCACCACACCTGGCCAATTTTTTGTATTTTTAGTAGAGACGGGGTTT CACCGTGTTAGCCAGGATGGTCTCCATCTCCTGACCTTGTGATTCGCCCGCCTCGGCCTCCCAAAGTGGT GGGATTACAGGCGTGAGCCAGCGCGCCCGGCCTTTTTTTTTTTTTTTTGAGACCAAGTTTTGCTCTTGTT GCCCAGGCTGGAGCGCAGTGGCGCAATCTCAACTCACTGCAACCTCCGCCTCCCAGGTTTAAGCGATTCT CCTGCCTCAGCCTTCCTGAGTAGCTGGGATTACAGGCATATGCCACCACGCCCGGCTAATTTTGTATTTT TAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTTGAACTCTCGACCTCAGATGATCGCCTGCC TCGGCCTCCCAAAGTGTTGGGATTACAGGCGTCAGGCACCGCGCCCGGCCATTTTTTGTATTTTTAGTAG AGACGGGTTTCACCGTGTTAGCCAGGATGTTCTTGATCTCCTTACCTCATGATCCACCCGCCTCGGCCCA AAGTGCTGGGATTACAGGCGTGAGCCACTAGGCCCAGCCGGGAATAGACTTCTTACTTGAGAAACTGAGT TTTGCAGTGAGGTCATTACTTTGGGATTCAGATTTGGCTCTGCCATTGAGAAGCTTTGTAATATCAGGCA AGTCACCTTACATTTCAGATTTCTCTCCTATAAAATCAAAATGATAGGAGTTCCTATTATGAGAACAATG ATGGGAAAGCTCTTTAAGAGTTTAAAGTATGGCTGGCGCCATGGCTCACGTCTGTAATCCCAGCACTTTG AGAGGCCGAGGTGGGCGGATCACTTGAGGTCAGGAGTTCAAGACAAGCCTGGGCAACATGGTGAAACCCT GACTCTACTAAAAATACAAAACTTAGCCAGGCGTGGTGGCACATGTCTGTAATCCCAGCTACTCAGGAGG CTGAGGCAGGAGAATTGTTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCTGAGATCGCACCACTGCACT CCAGCCTGGGTGACAGAGTGAGACTCTGTCTCCAAAAATAAAAATTAAAATTAAGTAGTACCTAAATAAA AAGGACCATTTCTTTTAAAGTCTCTCAGCAACCTGATTAAGATATAGAGATATATCTTTATTTTAATTAC AGTAAATTTAATCATAAAGGATGCAGTCACCCAAGAAGTTATATAGAAGAGGATCCAGGGTGGAATTCTA AGGAAGTGGACAGTGTCCCTCATGCTGTGTGCTCCCCTGTCATAGCATTTGTCAATGTGTATAGGAATAC ACACAGCACGGGTTGGCAAACTAATTAAAAACTGTTAAGAAAAGGATGGTTGGCCTGCACTGTTGGAGGC TCACATCTGTAATCCCAGCACTTTAGAAGGCTGATCAGGAGTTTGAAACCAGCCTGGGCAACAAAGCAAG ATGCCATCTCTACAAACAAACAAACAAAAACATCAAACAAAAAAAAACATAAAAAGAAAAGGATGCTGTC TCAGAGCCCCACCCTCACTACCCTCACCTCAGATACTCCCTTAACCTTCTGGATAAGATATCTTAGTCCC CCAGGTCTGAGCCTTGGCTGGATCTAGGCTTGATAGGCAAGGGAGTTGCTAGGGATCAAGGCTCATGCCT TTTTTTCACTGGGTGCCTAGAGCTCTGCCTCATCCTAATAAATCTCTAAGGAGAGATCTTTGGGTGTGTA GTTCACTTGATTTTGCAACATTGTTCAAGGAATTTTCTATCAGGTAGACTTATAGAGCCCTCTAGATTAA GTGCAAACTGAAGTAGGTACCTGAGAAGCCCAATGTAGGGCCTGGCACGGTGGCTCACACCTGTAATCCC AGCACTTTGGGAGGCCGAGGTGGACGGATCACGAGGTCAGGAGATCAAGACCATCCTGGTTAACACGGTG AAACCCCGTCTTTACTAAAAGTACAAAAAAAATTAGCCGGGCTTGATGGCAGGCATCTGTAGTCCCAGCT GCTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCTGGAGGCGGAGCTTGCAGTGAGCCGAGATCGCAC CACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCAAAAAAAAAGAAAAAAGGAAAATCCAATG TAGCTTTTAGCATATTGGATTTGGAGTCCGAAGAGTGGACTCCAGATCAGTCATTAGCTGTGTGATCTTG AGCAGGCACTTAACTTCTCTGAGTCTCAATTCAATTCATTGAATCTTTATTGAGCCTCTGTGATATACAA GGCATATTAATCCTTGCCTTCAAGGGGTACCCAGTCTTGTGGATATAGTCATGTAAATAATTCAGATATA AAACAATCCTAGCACTTTGGGAGGCTGAGGTGGGCATATCACTTGAGGTGAGGAGTTCCAGACCAGCCAG GCCAACATAGTGAAACCCCACCTCTACTAAATATGAAAATTAGCTGGATTTGGTGGCACGCACCTGTAAT CCCAGCAATTTAGGAGGCTGAGGCAGGAGAACTGCTTGAACCTGGGAGGCAGAGGTTGCACTGAGCCGCC GAGATAGTACCATTGCACTCCAGCCTAGGCGACAGAGTGAGACTCCGTCTCAAGAAATAAAAAAAAAAAG AAAAGAAAACTAATGAAGTGCTGTATACAAATTGCATGTAGAGGAAAAGACCATTTATTTTGATCAAGAA AGGGTTTGGAGCTTGAGGTGGGCTTTGTAGTATGAGCATCATCAAAGAAAGGAGGACATTTCAGGTCAAA GGAATAGTCTGCACAGAGGATACTGTGGTGTGAAGGTGAATGTCATGTTCAGGATACTGATCATAATCTG GTGTGTCTGGAGCACAGGTTGGCAAACTTTTTCTATATAGGGCCAGATAGTAAATATTTTAGGCTTTATT TTGCCATATGCTTGGGTGTCTGTGGCAACTAAACTGCTCAGCTCTGCCACTGTAGTGTGAAAACAGCCAT AGAGGAACTGTAAACGGATGGGCATGGCTGTGTTCCAATAAAATTTTATTTACCAAAACAGGCAACTAGT TGTATTTGTCCCAAGGGCCATAGTTTGCCTACTCCAGTCTAGAGCAAAGAGAGAGAGAGAGTGAGTGTGT GTGTGTTGTGGGAAAGGGTGGTAGCAGGAGATGAAGCTGGAAAGGCAGGTTAAGAAAGTCCTTGGATGAA GCTGGAAAGGCAGATTAAGAAAGTCCTTGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGG GAGGCCGAGGCGGGCAGATCACAAGGTCAGGAGATCAAGACCATCCTGGCTAACACAATGAAACCCCGTC TGTACTAAAAATACAAAAAATTAGCTGGGCATGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCT GAGGCAGGAGAATGGCGTGAACCCTGGAGGCGGAGCTTGCAGTGAGCTGAGATCGCGCCACTGCACTCCA GCCTGGGCAACACAGCGAGACTCTGTCTCAAAAAAATAAATAAATAAAGTAAAAGAAAGTCCTTGAATGC TGGCCAGGCGCGGTGGCTCACACCTGTAATCCCGGCACTTTGGGAGGCCGAGGTGAGTGGATCAACTGAG GTTAGGAGTTTGAGACCAGCCTGACCAACAAGGTGAAACCCCTTCTCTACTAAAAATACAAAAATTAGCC AGGCATGGTAGCACATGCCTGTGATGCCAGCTACTTGAGAGGCTGAGGCAGGAGAATTGTTTGAACCCAG GAGGCGAAGGTTGCAGTGAGCTGAGATTGCACCACTGCACTCCAGCTTGGGCAACAGATCGAGACTTGTC TCAAAAAAAAGAAAGTCCTTGAATGCCAGTCTTCTGAAGTTATTATTATTAAATGTTGAGACCCAGCCTG GTCTTGAACTCCTGGGCTCAAGTGATTTTCCTGCCTCAGCCTCCAGAGTAACTGGGATTACAGGCTCATG CCACCATGCCTATCTCTATTAAAGTTATTCTTTACTCTTTATCCTGTAGGGGATGGGGAGCCATAAGGAT TTTTTGAGCGAAGGAGTGATGTTATCAGAATTGTGGATTAGGAAAATAACTCTGGTGACAGTGTGGCAGG TAGTGTGAATTGAAGGTAGAGGGACCAATTAGAAGGCTAGTGTTATAGATTAAGCATGTGATAAGTTTTA GTTTTCTTATCTGTAAGGTGAGAATAATAATACCCCCTGTCCTACCCATGTTACTGTGAGGATCCAGTAA GAAAACGAAGTGAATGTGCTTTGACACCATAAGTGTTACAATATGTAGGAGGTGAATTGTGGCTTCTAAT AATTCTGAGTAGCGATGGTTATTTTTCTGTTGTGGGAGGGAATTCCTTGGAGGTATAGTGAGGTGAATCA TTTCACTGGCTGTTGTTCCCCAGTAGCTTTGGAATGAACCCCTCTTGCTATGTAGTGCCTGTGGGTTCCA GAAGAAAGTGAGCTAGACTGAACCTTAAATGTTCACCTCACCAGGGTCCCTGCTTTTTTTTTTTTTTTTC TTTTGGAGTTACCCTTCAAAAGGTGGGAGAGAATCTTGGAAACTAGAAATGAGCCAGAAAGAATTTGACT GGGAGTTCGCTGTAAAAATTCCTGGGTTCTCCTGGTAGTGTATGCCTAACTGTGTTAGTGAAGCTGTCAC TCTCTCTTCTTCAGGGGATGTTGGAAATTACTATTATGGACAAGGCCACCCAATGAAGCCTCACCGAATC CGCATGACTCATAATTTGCTGCTCAACTATGGTCTCTACCGAAAAATGGAAATCTATGTGAGTTACCAGA GGTGCTACCGCTCCCTAACCTCATCTGCTCTGGTTCCCCATATGCCATTCATTATCTCATTTTCTCCACC ACTCATTCACTCATTCATCAAATGCATGTTGACTGCTGTTACAAGGCAGGTACTGTAAATGATAAAGATT TTTGGCTGGGCATGGTGGCTCACGCCTGTAATCACAGCACTTCAGGAGGTGAAGGCAAGAGGATCACTTG AGCCTAGGAGTTCTAGGCCAGCCTGGGCAACATAGGGAGACCCTGTCTCTACAACAAAATTTAAAAATTA GCTGGCCATGGTGGCATGTGCCTGTGGTCCCAGATACTTGGGAGGCTAAGGTGGGAAGACTGCTAGAGCC TGGGAGGTCGAGGCTGTAGTGAGCTATGATTGTGCCACTGCATTCCAGCTTGGGGGGCAGAGCAAGACTC TGTCTTAAAAAAACAAAGCCAGGTGCGGTGGCTCATGCCTGTCATCCTAGCACTTTGGGAGGCTGAGATG GGCAGATTGCTTGAGCCCAGGAGTTCGAGACCATCCGGGTCAACATGGCAAGACCTCATCTCTACAAAAA ATTAGCCAGGCATGGTGGCACATGCCTGTAGTCCCGGCTACTTAGGAGCCTAAGCTAGGAGGATCATTTT GAGTCTGGGAAGCAGAGGTTACAGTGAGCCGTGATTGCACCACTGTGCTCCAGCCTGAGCGACAGAGTGA GACCCTGTCTCAAAAAAACAAAACAAAACAAAAAAACCAAAAATTTAATGCCTAAATAAGAGTGATTGGG ACCATGTTGAAGCAGATGCCAAATCTCTAGTTATTAGAGAGTATAGACGGTCTAACCTGTAGATTCAGCT ACAGGTGATTTGTCACTGATCTTTGAGTTTTTAAAGAGAAGCTGGAAATCCAGATTATTATGTAAAATCT CCTAGGTTTAAAATGTTATCCCAAGAAACCTTGTCTGTACAAAAAATATGAAAAAAATTAGCTGGTATCC TGGCCTGCACCTGTAGTCCCAGCTATCTGGGAGGCTGAGGTGGGAGGACCACTTGAGCCTGGGAGGTCAA GGCTGCGGTGAGCTGTGATTGCACCACTGCACTCCAGCCTAGATGACAGAATGAGATTTTGTCTCAAAAA AAAAGTTAACCCAGAGTTTTTGCTTTTTGGTTTTTATTTTAAGCATGTATACAAACCAAACACATTAGTA CATCTGTAGACCAAATAGGTCCAATGGTTCCCAGTTTTAACCTCTCTGGAGACAGTGAGGAGGAACAAGT GAAGGGTTTTAAATGAAAGAGAGATAGGAACGGGCATGCATTTTAGAAGCAGGGAGGCTAGGTAAGTGGC TGTTACAAGAGTCCAAATGAGAAAATAAAGAGGGGCTGGAGGTGATGTTGCCTTACTACATAAGAATCTG TGGTTAAAGTCTGTTTCTACAGCTTGAGTAAACTACCAACAGTGGTATTTTTGTCACCATTCCAGAGACT GAAAGGAGATGAGTGTTCTTTCCTAGATGGCCTTGTCATGTCTCTGGAGCCAGTGGAGGCAACTGGGGAA GCAAGGAAGGAAAGTAGAGGAGAAGACAGACCTTGGGACTACGGAGCTTTTTTAGGTGTGAAGGCAGCTG GGAATGAAAAACAGAAAAGGCAGAAGATATTTTTAGGTACTCTAGGGAGCAGACTATCTCTGCTCCCGAG AGCTCTGCTCCCTGCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTACAGCCTTGAACTCCTGGGCT CAAGTTATCTTCCCACATCAACCTCCCAAGTAGCTAGGACTACAGGCAGGCACCACCATGCCTGGCTTTA TTTTATTTTTTTCTTTTTTTTGAGACAGGGTCTCACTCTGTCACCCAGACTAGAGTGCAGTGGTGCAATC TTGGCTCACTGCAACCTCTGCTTTCTGGGCTCAAGTGATTCTCCAGCCTCAGCCTGCCAAGTAGCTGGGA TTAAAGGTGTAAGCCACCACGCCTGGCTAATTTTTTGGTAGAAATGGGGTTTCACCATTTTGCCCAGGCT GGTCTTAAATTCCTGAGCTCAAAGCAATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATG AGCCACCATACCCAGCCTCTCTTGGCTAATTCAGAAAAATTTTTTTGTAGAAACAGGGTCTTGCTGTTTT GTCCAGGCTGGTGTCAAACCCCTGGCCTCAAGAGATCTTCTTACTTTGGTCTCCCAAAGTGCTGAGATTA TAAGCATCAGCCACCATGCCTGTATTCTTTTTTAAAAATTATAAAAATGATTTTTATTTTTTACCTGCAG TTCCAAGCACAGTATGTTTTAGTTTTACATGTTTGATTGTTATATAGATGGAGCCATACAGTATTTATTA TGTGACTGACTTTTTTTGCTAAACATGTTCTTGAGACTCACCCATGTTGATACCTGTAGCTGTATTTATT TTTACTGTATTTCATTGAAATAAATGTATTCTAGTCTGTTATCTCTTTGATGAGCATTTGATTTGCTTCT GGGGTTTGACTATTGCAAATACTGCTGCTATGAACTTTCTTGAACATGTCTCTTGATGCATATATGCTAA AGTTTCACTAAAGGATATACTAGGATTAGAATTGGGTCAGGACATATGCACATATTCACCTGTGTTAGAT AAAGCCAAAATGGTTTCCAATTGCCAGCTATGTAGGAGAATTGCAGTTGCTCTGAGTCCTTGCCAACACT TGATTTTGTCAGATTTCAATTTTGTTGCTAATTTAGGTAGACATGAAATGTTATCTTACTATTATTTTAA TTTATATTCCCCTACTGAAATTCCTATTCAACCTTTTTGCCCATTTTCCCATTGGTTGTCTTTTTTTTTT TTTTTTTTCCCTGAGACAATGTCTCACTCTGGCACTCAGGCTGCAGTGCACTGGTGCGATCTCGGCTCAC TGCAACCTCTGCCTCCCAGGCTCAAGCCATCTTTCTACCTCAGCCTCCTGAGTAGCTGGGACCACAGGTG CATGTCACCACACTCGGCTAATTTTTATATTTTTGTAGAGATGGGGTTTTGCTGTGTTAACCAGGCTGGT CTGAAACTCCTAGGCTCAAGTGATCTGTCCACCTTGGCCTCCCTAAGTGCTGAGATTACAGGCGTGAGCC ACAGTGCCTGACCCATTTCTTTTATATATTAAATGTCCATTTTTATTCATTCATTGCATATATACTCATC AAGCACCTACTTTGTGCCAGGCAATATGTGTGTGTCTGGTTTTGGGCTCTCTGTTCGGTTGACTTGGTCT GTTTATTGACCCATATGCCAATACCACAGTGGCTTAATTACAGTAGCTTTATATTATAGTAAGTCTTGTT ATCTGGTAGCACAGTCCTCCCACTTTGTTCTTCTGAAAAAGTGATTTGGCTATTTGCCCTTTCACTTTTT TTTCTTTTTCTTTTTCTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCA ATGGCGCGATCTTGGCTCACTGCAATCTCCGCCTCCCTAGTAGCTGGGATTACAGGCATGCGCCACCACG GCCAGCTAATTTTGTATTTTTGGTAGAGATGGGGTTTCTCCACGTTGGTCAGGCTGGTCTCGAACTCCCA ACCTCAGGTGATCCGCCCGCCTTGGCCTCGCAAAGTCCTGGGATTACATGTGTGAGCCATGGCGCCCGGC CTCTTTTTCTCTCTTTTAGAGACAGGGTTTTACTCTGTTGCCTGGGCTAGAGTGCAGTGGCACAGTCATA GCTCATTGCAGCCTCAAGCTCCTGGACTCAAGTAATCCTCCCTCCTCAGCCTCCTGAGTAGCACTTCTTT TTAATTTAATTACGATTTTGATATACATTTCACTAATTCACCAAGGTCTATGTAGATCTGATTCTGTTGT TTGTTGTTGTTTCTGTAGGATCCTGGACTGTGTTTCCTGTGTATTTTGTGATTTTTGACTGTGGGATAAT GCAGTAGGCCACTCTTATCTGAGGGGGGATACTTTCTAGTATGCCCAGTAGATTCCTGAAACCATGGATA GTACTGTATCCTATATATGTTATATTTTTTCTAATACATACATACCTCTGATAAAGCTTAATTTATAAAT TAGGTACAGTAAGAAATTAACAATAATAAACTAGGACAATTATAGCAATAAGCCGTTTACAGTTTCATGC ATAGAAGATTCATTCCTGGCCGGGCGTGGTGGCTCATGTCTGTAATCCCAGCACTTTGGGAGGCCAAAGC CGGTGGATCATCTGAGGTCAGGAGTTCGAGACCACCTTGATTAACATGGTGAAACCCCATCTCTACTAAA AATACAAAATTAGCCAGACGTGGTGGTGCATACCTGTAGTCCCAGCTACTCAGGAGGCTGAGACAGGAGA ATCATTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATCTCACCATTGCACTCTAGCGTGGGCAAC AAGAGTGAAACTCCTTCCCAAAAATAAAAAAAAAGAAGATTCATTCCTACTGTAGATCTTAGCTCTTAGC GACTTCAGCACAGGATTTTTTTCTTTCCTTATATTGAGAACTTCAACCTTTTCATGTAAAGGAAGCACAG CACAGCTTCTCTTTGGCATATCAAAATTGCCAGCATCACTACTCGTGGACTTTGGGGCCATTATTAAGTA AAACAAGGGCTTCTTGAATACAAACAGTGTGATACCTTGATAATCGATCTGATTACTGAGAGGGCTACTA AGTGACTCACAGGTGGGTAGTATACAGTGTGGATATGCCAGATAAAGGGATGATTCACACCCAGGGGACA GAGCTGGATGTTACAAAATTTCATAACAAATGGTTCACAATTTGAAACTTATGAATTGCTTGTTTCTGGC ATTTTTCATGTAATATTTTTGGACAGTGATTGTGTGTAACTGGAACTGTAGAAACCAAAACTGAGGATAA GAGGGCACTGCTGTATTCTTTGGAACTTTGAGTCCTGGGATGAAGATGGATTGTTAGAAGGTGATTTGCT TTTACTTTGTAAAAGAGGTGGCATTTGAGATGAGCCCTTTCCTTCAGAGATTTGGGATAAGGGATGAATT TCAAATAATAGGAAGAACATGAGCACGGACACTGTTGAAAAGCTCTATACCTCTCTAGATCTTAAGGAAG AGTTGTTTGGAGTATAATATTTGTGAAAGAGAGCAGGGGCAATTAAATTGGGAAAGGAACCTTGTAAAGT TTCTTGATTGCTATATCAAAGAGCTTAGAGTCTTTACTTCGGGCCGGGCGCAGTGGCTCACGCCTGTAAT CCCAGCACTTTGGGAGGCCAAGGTGGGCGGATCACCTGAGGTCGGGAGTTTGAGACCAGCCTGACCAACA TGGAGAAACCCCATCTCTACTAAAAATACAAAATTAGCTGGGCATGGTGGCACATGCCTGTAATCCCAGC TACTAGGGAGGCTGAGGCAGAAGAATAGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATCGTG CCATTGCACTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCAAAAAAAAGAATATTTACTTCGTCAAC AGGGTGTCATTGAATGAGAGCAGTACTTTAACGTTTTAAGATTTTTGTGATACCAATATGGAAGATGGAA GATGATAAGGCTGGATAGAAATAGGACCAATTAGGAGGCCAAAAATACTCCAAGTGAGATTTAATTTGTG TATGGGTTTTGTTTTGTTTTGTTTTTTTAATTTTTATTTATTTATTTTCTGGGACGGAGTCTTGATCTGT CACCCAGGCTGGAGTGCAGTGGCGCAATCTCGGCCCACTGCAAGCTCCACCTCTTGGGTTCATGCCATTC TCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCTGCCACCACGCCTGGCTAATTTTTTGTATT TTTAGTAGAGACGGGGTTTCCCCGTGTTAGTCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGC CTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACGGCGCCTGGCCCGTTTTATTTTTTTAGATA GGGTGTTGCTCTGTCATCCAGGCTGGAGTGCAGTGATGTGATCACATCTCACTGCAGCCTCACCCTCCTG GGCTCAAGTGATCCTCCCACCTCAGCTTCCTGAGTAGCTGGAACTACACTGTGTGCTACTATACCTGGCT AATTTTTGTATTTTTTATAGAGATGGGGTTTCACCTTGTTGCCCAAGCTGGTCTCAAAGTGCTGGGCCCA AGCAGTCTGCCCCCCTTAGCCTCCCAAAGCGTTAGGATTATAGGCATGAGCCACCACGCCCAGCCAAGAG TTCATTTGTTAGGTCAACAGTTATTCATTGAGCAGGTGCTATATGTCAGGCACCATGCTTGTTGCTTCAA ATAAAGGTAGAACCTGCTCCTGGCCTCCCAGAGTAGACCAAGCAAACATGCAATTTATATGCAGTTTGGT GAGTGTAATGATAAGGGAAGTACAGGCTTCTCAGGGTAGCATTTCAGAGAGTTACTTAACTGAGATTCTG AGAGGTCAAGGACAGCTTTTTGGGGGAATTGGCTTTTCTTCTCTTTCTCTCTCTCTCTCTTTTTTAAGAG ACAGCCTTGGCTGGGTGCCGTGGCTCACGCCTGCAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATC ACCTGAGATCAGGAGTTCAAGACAAACCTGGCCAACATGGTGAAACCCTCTCTCTACTAAAAATACAAAA ATTAGCTGGGCATGGTGGTGGATGCCTGTAATCCCGACTACTCAGGAGGCTGAGGCAGGAAAATCGCTTG AACCTGGGTGGCGGAGATTGCAGTGAGCTGAGGTCGTGCCACTGTACTCCAGCCTGGGCAACAGAGCGAG TCTCAAAAAAAAAAAAAAAAAAAAAACAAGCCTTGCTCTGTTGCCCAGGATGGAATGCAGTGGCTATTCC TAGGTGAGATTATAATGCACTATAGCCTCAAACTCCTGTCTGTGCTCAAGTGATTCTCCTGCCTCAGCCT CCCAAGTAGTTGAGACTACAAGTGTGTGCCTGGGTTGACTTTTCATTTGCAACCTAAAGGTTGAGTAGAG GGTGTGAAGAGAACAGTGTTGTAGGTCATAGCATGTATAAAGGCCTAAATGTGAGAGAGATGGCCCTTGG GGAAGTGCAAGCAAAATGGTGCTTGGCAGATTGGCACAGTGAATGAGATCAATTCAGTCTCTCAAACATG TTTTATTTAACTCAAAGTATTTTAAGGGCATTAGGTTAGTGGCCAACCTTTAAAAAATGAAATTGTCCAG AAAGGATCTGGCAGTTGGGCCCAAATTCCCTCATGGCAGCCATCAGCTAGAGCTATGTAAATAAAGATTG TCCTCTGCTCACCAGTGTTTTGTTTATGTTTGTTTTAAGCTAGCTAAACTGACTGGCGCTTATGAGTGAT TTGAGTTTGGTGTTCCCTGGCATACAGCACAAAATATTTAGGTGAGTGTAAGGGGGTGAGCAGGGATCAG ATTATTCTGGTTTTCCAAGCCAGGTTAAAGAGTTTGAACTTGATATTTTGAGTAATGATGCCTTTGAAGT GTTTTTAGAGGGGAGTGACATGATTCAGTTTGCATTTTAAGACTGATAACTCTATAACAGGCACAGTGAC ACACGCTTGTAATCCCAGCTACTAGCAAGGCTAAGGCAAGAAGATCACTTGAGCCCAGGAGTTCGAGACC AGCCTGGGCAACACAGGGAGATTCTGTCTCTAAATAAAAAAGAAAAAGACAGGCCGGGCGCAGTGGCTCA CGCTTGTAGTCCCAGCACTTTGGGAGGCTGAGGCGGATGGATCACCTGAGGTCAGCAGTTTGAGACCAGC CTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCGGGAGTGGTGGTGGGAGCCT GTAATCCCAGCTACTCGGGAGGCTGGGGCAAGAGAATTGCTTGAATCTGGGAGGCGGAGGTTGCAGTGAG CCAAGATTGTGCCATTGCACTGCAGCTGGGTGACAAGAGTGAAAGTCGGTGAAAAAAAGAAAAAAAAAAT AGAGAGACAGAAAGAAACAGGGAGAGGGAGGGAGAGAGAGAAAGACAAAGAAGGAAGGAAGAAAGGAAGG AAAGAAGAGAGAAAAGAAAAAAAAAGAAAGAGAGACAGAAAACTCTGCCTGTAGTATTCAGCATAAATTA ACAATGGTTAAGAAGGAGGCTAGTATACCAGTTAGGAGATTGTTGCCAGAATCCAAGTCAAAAAAAGTGG TAGCCCAGGATGGAAGTGGACAGATTTGACAGATAATACATTGGTGGTAGTTTCAAGAGAAGTTGAATGT AGCGGATGAAAAAAGAAGAATCAAAGATGATTCTTGCCTGGTGTGGTGTGGTGGCTCATGCCTGTAACCC TGGCGCTTTGGGAAGCCAAGGCCAGCAGATCACCTGAGGTCAGGAGTTTGAGACTAGCCTGGCCAACATG GTGAAACCCTATCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGTCGCGGGTGCCTGTAATCCCAGCT ACTCAGGAGTCTGAGACGGGAGAATCGCTGAACTTGGGCAGCAGAAGTTGCAATGAGCCGAGATCGTGCC ATTACACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCGAAAAAAAAACAAAGATGATACCCTGGCTT CGATCTTGAACAACTAGGTGGTTGGTGCTGAGAATAGGAAACCCGGGAAAGAAGGACATAGGAAAAATAG GGTAGTAGATGCAATCAATATTATGGAGGCATAATGAGAGAGATTGGCAATGGATTGAAACAGGAAGGCA AAAAAGGACAGAGTTTAAAATGACACTTAGGTTTTCAGCCTGAGTGGATGTTGGTATCATTAACAAAAAT AATGAAAGAGAACTTTTGGAAGTTAAGTGGAATTTGAGTGCTTCTAGGCTCTCAACAACAAATTGTTGAG TCCAGTTGAATTTGAAGTGCCTTTAGGGTTTGTGGGTGGAGCAGACTGAGAAGCTATTTGAACTGTGAAT CTGGAGCTCAGAACTAAGATCAAAATGGAGTTTGTGCAGTCATCTGTGTAGAAGGGATAGCCAGACCAAA GTTTTGATGACATTAGGAAGAGAGTAAAGGGCTTAGTATAGTAAAAAAACAACTTGGTATTTGGAGCTAA GTCTTTTTTCTTTCACTGTGGGTGTTTTGGTTTGCCTTTTTAGAAACAGGGTCTCACTGTGTTTGCCCAG GCTGGCCTTGAACTCCTGGGCTCAAGTGATCCTTACATCTTAGATTCCTGAGCAGCTGGGACTACGGTGC ATGCCACTGCATCTGGCTTCACTATGGCTGTTTTTGATAAAACAGTATCTGTCGTTCAGTCTTATTATGC CTCATTAAATTAAGTGAGGATTAAATGAGAGAGTCAAAGTACCCAGAGCCAGATCTCTGGATTCCTTCCA GTTTACCAGCTGTGTAACCCCAGGCAAATTACTTAACCTCTCTCTTCTATAGTTTCCTCCCTGTGAAATA AGGATAATAATAGTATGAATTTTTTATTTTTATTTTTTCTTTGTGATGTAGTTTCACTCTGTTGCCCAGG CTGGAGTGCAGTGGCATGACCTAAGCTCACTGCAACCTCTGCCTCCTGGATTTAAGCGATGCTTTGCCTC AGCCTCCCGAGTAGCTGGGTTTACAGGCGCCCGCCACCACACTCAGCTAATTTTTTATATTTTTAGTAGA GATGGGGTTTTACCATGTTAGCCAGACTGGTCTCGAACTCCTGACTTCAAGTGATCTGCCCCGCTCAGCC TCTCAAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCTGGCTATGAACTTTTTTTTGTTTGTTTGCTT GTTTTTTGAGACAGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCACAATCTGGGCTCACTGCAA CCTCTGCCTCCTAAGTTCAAGTGATTCTCATGCTGCAGCCTCCTGAGTAGCTGGGATTACAGGAGCCTGC CACCACGCCCAGCTAATTTTTGTATTTTTTGCAGAGATGGGATTTCGCCATGTTGGCCAGACTGGTTTGA AACTCCTGGCCTCAAGCAATCCTCCCACCTCGGCCTCCCAAAATGCTGGGATTATAGGCGTGAGCCACCG CACCTGGCCATGAACTTTAAAAGGTGTTTTTTTGTTTTGTTTTGTTTTTCAGAGATGGGGTCTTAGGAAT CTGAACACATTCTGGCCTGGAGAGATTGCCCAATAACTTATTTTATTTTATTTATTTATTTATTTATTTA TTTATTTGAGATGGAGTCTCGCTTTGTTGCCCAGGCTGGAACGCAGTGGCATGATCTCAGCTCAATGCAG CCTCTGCCTCCGAGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTCCAGGCACCTGCC ATGACGCCCGGCTAATTTTTGTATTTTTATTGGAGATGGGGTTTCGCTGTGTTGGCCAGGGTGGTCTTGA ACTCCTGGCCTCAGGTGAGCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGC GCCTGGCCCCGATAATTATTTTAAAAAAGAGAAAAAGACAGGGTCTCACTATGTTGTCCAGGCTAGCCTT GAAGTCCTAGGCTCAAGCGATCCTCCAGGGCTTAGATCTTTAAAAGGTTGTTGTAAGAATCATATGAGAT AGCGTTTAAAGTGCCTGAAAGAGTGACTGTCACAGAGGAAACAATAAATGTTGGCTGTGTATTGAAAATG CTTTATAAACTGCAGAAAATATGGCAGGTTCTCAAATAACATCACTTCGCTCAGCATCATTTAGTTATAA CGTTGAGGAGAAAAATAACTGATTCCTGGCATGGCCACTATCTGTATGGTGTTTGCATATTCTCCCCATG TCTGTGTAGGTTTTCTCCGGGTACTCCATTTTTCTCCCACATCCCAAAGATGTGCATGTGAGGTGAGTTG GCATGTTTCCATGGTCCTAGTCTGAGCAAGTGTGGATATGGGTGTGAGTGCACCCTGTGATGGAATGGCG TCCTGTCCAAGGTTGGTTCCTTGTGTTGAGCTGCGGGACAGGCTCTGGCCACCCTTGGAAATGAATGATT GAATTCAAATTATTGTCAAGTAAAAATTCATAAAGTAGACAATAATCATACAGATGCACAACAATAAAAG ATGTGATACAGAAACACTCAGCGAGCCTGCCATATTTGTTATTGTTCGTTTTTGAACTGCATGATGGTAG AAGGTTCTCCTTGCAATTTTAACTTTGCATACATTTATTATTTGATTTAACCCACCACCACAACAACCGC CATCACTCACTGATTCACCAAAAATTGGGTAAATAATAATGTATATATTTTTTGAGACGGGGTCTTGCTC TGTTGCCCAGACTGTAGTGCAGTGGCAAGATCACAGCTCACTGCAGCCTGGACTTCCCTGGGCTCAGGTG ATCCTCCCACCTTAGCCTCTTGAGTAGTTAGGACTATAGGCAAGTGCCACCACAGCCAGCTAATTTTTTA TATTTTTGTAGAGACAGGGTTTCACCACGTTGCCCAGGCTGGTCTCAAACTCCTGGGTTCAAGTGATCCA CCTGCCTCAGCCTCCCGAAGTACTGGGATTTTAGGCATGAGCCACTGCACCCAGCCCAATAATGATCTTC CTTATTTTTATAAATATTTCTTAAATATAGAGATATTTCGCCGGGCAAGGTGGCTCATGCCTGTAATCCC AGCACTTTGGGAGGCCGAGGCGGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACATGGTG AAACCCCATCTCTACTAAATGTACAAAAAATTAGCCAGGTGTGATGGCGGGCGCCTGTAGTCCCAGCTAC TTGGGAGGCTGAGGCAGGAGAATGGTGTGAACCTGGGAGACAGAGCTTGCAGTGAGCCGAGATCGCGCCA CTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAGGGATATTTCACA TTTATTTCAGTATTTGATGTTTGAAGTGTTTTGGGTCTTTATTTAGAATTTTAGTGATGTTTTTGTGACA GAAATATGCTGTAGGAGCTTAAGTTCTTGTTTATATCAATTAGCCTATGGTAAAATTGGTTTCTTTATAC ATTGTTTTGCCTATAGTCACAATTTCCAAGAACCTGTGGATGACATTAAGTGAGGACTTTTGTTGTATTG GTAATTAGAGAGGCAGAGGGTCATGTTTGAAGAAGACCTACCTTTAAGGGATGGGAGGAAAAGGAAATAA TTTTAAAAAGGGAAGGAGGAGTCAGAATGTTGGGATAACCAGGAAATTAGCTTGTCAAGGAAGTGTTAGT GGGGAGGATGTGATCAAAATTGTTGATGTGATGACTTATAAAGGATTTCCCATCTGTTTCAGTTTTCATT AGATACCCTTTTTTCGTGAACTCTTGGAGCCATTTTGTCCATAATTTTATAATACGTATATATACATATA TATTTTTTTTAATTTATTTTTTTGAGAGGAAGTTTCACTCTTGTTGCCCAGGATGGAGTGCAGTGGCACA ATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTCCTGTCTCAGCCTCCTGAGTAGTTG GGATTACAGGTGCATGCCACCACGTCCAGCTAATTTTTGTATTTTTAGTAGAGACCAGATTTCATCATAT TGGTCAGGATGGTCTCGAACTTCTAACCTCAGGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATT ACAGGCGTGAGCCACTGCACTCGGCCAGTTTTATATAATAATAAGTAATAATTTTGTAGGCCGGGCGCAG TGGCTCATGCCTGTAATCCAGCACTTTGGGAGGCCGAGGAGGGCGGATCACCTGAGGTCAGGAGTTCGAG ACCATCCTGACCAACATGGTAAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGCGTCGTGGTGGG CGCCTGTAATCCCAACTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGAAGGTTGCA GTGAGTCGAGATCATGCCATTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGCCTCAAAACAAACAAA CAAACAAAAAAAAACGAAAAAAAAGGTCGGGCTTGGTGGCTCATGCCTGTAATCTCAGCACTTTGGAAGG CCGAGGCGGGCGGATCACGAGGTCAGGAGATCAAGACCATCCTAGCTAACACGGTGAAACCCTGTCTCTA CTAAAAATACAAAAAAAATTAGCCGGGCGTGGTGGTGGGCGTCTGTAGTCCCAGCTACTTGGAAGGCTGA GGCAGGAGAATGGCGTGAAGCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCACTCTAGC CTGGGAGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAGTAATAATTTTGTAAAGCACCTTACAGTTTAC AAAGAGATTTAACAACCTCTTCCAATTCTCTCAACTTCCCTGTGTGGTCTATGTTGTCCCTGTTTAGTAA ATGAGGAAATGGAGGTTCAAGAGACAGTAACTTGCCTAAGCAACAGAGCTTGAGCTGCTGTAGGTCTTCT GATACTCTGTCTCCTTTGATAATCTTGTTTGCCTAGTTAGATTGTAAATTTCTTGAAGCCTGAATCTAAC CAGTTATTTCTTTTTATTCTTTATAGCACCTAGCTCCATGCTGCGCAGGAAATATAAATATTCAAACTAG ATTGACTGGACTGGCCGTGGTCAAAAATAACTTGCCCTTTCTCCCTTCTGCCCTCTAGCGCCCTCACAAA GCCAATGCTGAGGAGATGACCAAGTACCACAGCGATGACTACATTAAATTCTTGCGCTCCATCCGTCCAG ATAACATGTCGGAGTACAGCAAGCAGATGCAGAGATGTAAGTCCATTCTGTTCCCTCACACTCTGAAGCC GCCAGTTGCATCTCCCTTTCCACTGTAGAGGCCCATTCTGCCGTCCTCGCACCTCCCATTCAGTGGACAC CTGATTTCCCCTACCTCCTAAAGGTGCCAGAGTGCTTTTTCCCCTCAAGTCGGATTTTTCATGTTTCCTG ATTTGTAAACGATAGAGGTAGTACTTTTTCTGGTTATGTTCACAACACTGTCCCAAGAGTACTGTAATTA TTGTAGTGGAAAAAGCACTGACCTGGGACGGGGAGACAATAGATACAGTAAAATTTAACTCTAACTCTCA GCTGAGTGGGCAAGTCACTTCCCCTCAGATTCTTCTTTTGTAAAGTGGGCTGGGCCACATGATCTCTGAT TTCTGTCCAACTGTAACTGTTTTGACTTAGTGGGTATTAATTGAGAATTTAGAGGCCACTCAGGACAGAT TCTAGATGGTGTAATCTTTGAGATGAGGTGATGCTGCCCCTGATCCCTTGGACTTGAACTTCAGAGCAGG TCCCATCTTGGAAGCCACGCTTAGTTTGTAGGAATCGTGGGAATTATTTTAGCTGTGAGGGGGAAAAAAA AAGTATTCAAATTTGGGACAAAACTATCATACCTGACTTCCCCCTTGTGTTATTTTAGAAATTATCTCTT AGCACCTAAGACTTCATATAGTATAACAGCACTGTCCAGAAGAAGTTTTGATTAACTTATGACAGCTTAT ATGGAAGTGTCAGAAAATATGCGGCACTTGTTTGTTGCTGCTGACCACAAGGTAGTCTTACTCCCAAGGA AGAAAGTTATTTATAACTATTATTACAACTAATAATAACTGTACAGTGGTATTGATGGCAGAACCACAGA GACCTTCCTTGAAGCATTAAGCTTCTTTGCTACCGACAACTCCAGGAGCTGCCAGCTGCTGTGAGTGAGG TGTTTGCTCTCTGAATTGCAGGGTCTTATTTCCCTCCAAGATGAGGCAAATTCATGCCTTTCCTGTAGAT GGCTTTAGAGGTTTCCATAACCCATTTAGGCCAAGGATCAGGCTCTACTCTCAGCACAGTGGGCTCTCAC TAGAGGAGCAACTTGCTATTAAAGTAAGAAAATAAGCTTTCATGTCTTAGTTTGAATCCTTGGTTTCCTA GCCCCTCTGGTGTTATTTCCCGCCCCTGCCACTTTTTTTTGAGACAGAGTTTCGCTCTTGTTGCCCAGGC TGGAGTGCAATGGGGCGATCTCTACTCACCACAACCTCCGTCTCCCGGCTTCAAGCGATTATCCTGCCTC AGCCTCCTGAGTAGCTGGGATTACAGGGATGTGCCACCACGCCCGGCTAATTTTGTATTTTTAGGTTTCT CCATGTTAGTCAGGCTGGTCTCAAACTCCCGACCTCAGGTGATATGCCAGCCTCGGCTTCCCCAAGTGCT GGGATTATAGGCCTGAGCCACTGTGCCCGACCTGTTTTCCCTCTTTAAGAGGAAGACAGGACAGGCACAG CGGTTCATGCCTGTAATCCTAGCACTTTGGGAGCCCAAGGTGGGAGGATTGCTTGAGCCCAGCCAGGAGT TTGAGACCAGCCTGGGCAACATAGTGAGACCCTCATCTCTACAAAAAAATAAAAAAATTAGCTGGGCATG GCGGTGCACACCTGTGGTCCCAGCTACTCAGGAGGTTGAGGAGGGAGGATCTTTTGAGCCTGGAAGGTCG AGGCTGCAGTGAGCCATGATTGTACTACTGCACTCCAGCCTGGGCAACAGAGCGAGACCAAAAAAAAAAA GACATTAGTGCCTATTTCATAGTCAAGGATGGGGGAATAAGTGAAGATAATATATTTAAATATATATAAT ATGTCTACCCTCAATGAATTGCTTTTGCTATTTTTGCTATTGCATAATCACTTTTGCTATTATGACTTAC TATTTTTATTATTTACAAACTTATCAAGGCAGACAAAATGCTATGCCCTGAGGAGTGTGCAGGTTCTGCT CTGGTGCGCCAATTTTTCCGAATCCAGCATTCTAAAGTTGTACATTAAAAAATTCAGTCTGGCTGGGTGT GGTGGCTTACGCCTGTAATCCCAGCAGTTTGGGAGGCTGAGGCAAGCAGATCACCTGGGGTCGGGAGTTT GAGACCAGCCTGGCCAACATAGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTTGGTTTGGTGG TACATGCCTGTAATTCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCAGAGGT TGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAA AAAATTCAGTCTGGGTGCCTATAGTCTCAGCTACTTAGGAGGCTGAAGCAGGAAGATTTCTTGAGCCCAG GAGTTCAAGGCCAGTCTGGGTAATATAGTGAGACCTGGTCTCTAAAAAAAATTTTTCTAATTAAAATAAT TAGGTCTTGGATTTTTCTGTCATCAGAAATGGGGGCAGGAAGAATAAGCCTCTCTAAGAACTTCAGAGTA CCTCACTGAGTTGATTTGTAGGGTTATGGAGGGTCAGAGTAGACAGAGACTTTAGATGTCACTTAACACA GTGCTTTATAACCTGGGGTATCTACCAAGACAGTAATGAGCCCTTTTTAAAAAAAGAATTATTTTTATTT TTATTCTTGTTTTTAGAGATGGGGTCTTGCTTTGTCATCCAGGGTACAGTACAGTGGCAAGATCATAGCT CACTGCAGCCTCAAATTCCTTAATCCTTAACTTGCCCTTTTAGAATATGTACCAATATCTAACCTAGGCG CTGGACATGGTAGCATGCACCTGTAATGCCAGTGCTTTGAAGGGCAAGGCAGGAGGGATAGCTTGAGGCC AGGAGTTCAAGACCAGCCTGGGCAGCATAGTGAGACCCCCATCTCTTATTTTATCTTAAAAAAATAAAAA TAAAAAATTAGTTGTGTATGGTGGCACATGCCTGTGATTCTGGCTACTCAGGAGCCTGAGGCAGGAGGAT CCCTTGAGCCCAGTTCAGGGCTGCATTGAGGTATGGTCTCATTTCGCCACCACACTCCAGCCTGGGCAAC ATAGCAAGAACTCGTCTCAATAAAAAAAAAACACACATGGCCAGGCGTGGTGGCTCATGCCTGTAATCCC AGCACTTTGGGAGGCCGAGGTGGGCGGATCACGAGGTCAGTACATCGAGACACCATCCTGGCTAACACGG TGAAACCCCGTCTCCACTAAAAATTTACAAAAAATTAGCCGGACGTGGTGGCAGGCGCTTGTGGTCCCAG CTACTCGGGAGGCTGAGGCACCAGAATGGTGTGAACCCGACAGGCGGAGCTTGCAGTGAGCCGAGATCAC GCCACTGTACTCCAGCTTGGGCGACAGAGCGAGACTCCTTCTCAAAAAGAAAAAAAAAAAAACCCACACA CACACAAAAACATCCCACACACCTAATCTAGGAAGTTATGCTTATGATAAGATCGAGTAAATCAGGTTTC CTTGCTTGTGGCTGAAATGTAATAAACCCTTTCTGGTCACTTTGAGAGCCTTGACCAGAAGTTCTGACCT AATATTTAGCAAGTGAAAATGGGAACACAAATAAATGCATTTAGGGGGCTTTTGGTGAAAACATGATAAA AGGGATTGGTAAAAAATTGGGAGACATTCTCATCCATTTTACAGACATGTAAACTTTCCCAGTCACACAG CAAGGTGATGGTAGAATGCAGAATGGAACTCTAGTCCCCCAATTCTGTAGTTTTAAAAAATATAGTGTAT ATAAAATATTTTAGATACACAGGCCAGGCAGGGTAGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTG AGGCAGGTGGATCACTTGAGGCCAGGAGTTTGAGACCAGCCTGGCCAGCGTGGTGAAACCCTGTCTCCAC CAAAAGTACAAAAATTAGCCATGTGTGGTGGTATATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCA TGAGAATTGTTTGAACCTGGAGGGCAGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGG GCGACAGAGCAAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAACAGAAAAAGAAAAAAACATATTT TAGACACACACAAAAAGCATCAAAAAATAATATAATGCACTTTGGGAGGCCGAGGCGGGCAGATCACGAG GTCAGGAGATCAAGACCATCCTGGCTAACACAGTGAAACCCCATCTCTACTAAAAATACAAAAAATTAGC CGGGTGTGGTGGTGGGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGTGTGAACCCA GGAGGCGGAGCTTGCAGTGAGCTGACATTGCGCCACTGCACTCCAGGCTGGGCAACAGAGCAAGACTCTG TCTCAAAAAAAAAAAAATAATAATAATAATATAATGAACATCCATGTGTGCCCAATACCCAGCCTGAGAA AGAAAACATTATCAATACAGTTGATGCCCCCTTGGGCATCTTTCCTTGATCACATACCCTTTCTCTCCCA CTCCCCCAGCCCCCCACCCCATTACCAGCACTGCCAAGGTATAAGCACTATCCTGAGGTTAGTGTTTAAT CTTCCCATCTCTTTGCAATGAGCATTTGACTGCCTTCTCTGCCTACGTCTGCTTCCACCTCTCACCCAGT ATTGCTTCCCTTTAGTCTAAAGCTAGTGTGAGAATGAGAAAAGCGTTTATAGCAGAAAGAGAGAAAACCC ATGGAAAAGTCTTCCCTACCCTCACAGATTAGCTCACATGAGTATCTGCTCTTCCATTTGCCCCCTTTCC ATCTCTAATCACATAGCTTATTGACTAGGAATAAAAGGGCTGGTCATTTGAGCTACATGTTGGTTTGGTG CCTGAAGAAAAATATTTTTTTTTTTCTCACGTCCAAAACACCCATTCCTTCCCATGGAGGCTCCATATCC CAAATAAGAGTATAAACAAAGCTTTGGAAACGCAGGCAGGCCAAACTCTGTGCAGGAGGAAGTGGCCAGA GAGGGAAATCAGTTGCCAATGGATAAACAGCCGGGGCCCAGGGACCAAAGTTCTTATTTACACAGCCTCC CAGTGTTTACCCAGGAAGTGAGGAAGAGACCCACCCGCTGCACACTCCCTCATGCAGCCATGCTTCTTCC TCAGAGCACCGGATCTTGGCACCCTCCAAGTTTAGTGCAGAACCAGAGCTGGTAACTCTTGTGGTTATTG TAGATCTTGAGCTTCAACTGTGTCTTGAGATTTTACCAGCACAATCCAAACTGAGCTCTTCTGCTCTCAC CCCAGGGCTGCTCCTTCCTCTACTTTTGGAAATCTTGATAACAGTGGGTACAGTAGAAGGCTGGGCAAGA GAATAAGTATGCAGCCCCACACCTCCTGCCTCTGACTTCCTGTAGCTCATTGATGTCTCAGCAGTTACTT TTTTTTTTTTTTTCTCCTGAGATGGAGTCTCGCCCTGTCACCCAGGCTGGAATGCAGGGGTGCAATCTTG GCTCACTGCAACCTCCACGTTTTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTA CAGGCACATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCTCCATGTTGGCCAGGCTAGTC TTGAACTCGTGACCTCAAGTGATCCACCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCA CCGCGCCCGGCCAGTAGTTACCTTTTCTGTAAGAGGAGATTTGGAGCTATAAAGTTCCTCTAGGTCTGTG AGTCTACAGCCTCCAGGTGTGCTTTCCTTCCTGTTTTCATTTCATTTGCCTTATTGTTTGCATATGTTTC CACATTATGTACTACTTGGTACTTTTACCCCATTAGGCCCGAAATAACTTTACTCCACTTGTCACTGTGA ATGTAGCAGTAAGACACTGGGCTACGGGAGTCAAGACACCGGGACCCTGATTCTGGTTCTGCTACTGCCT GGTTTTATAACCTTGGGCAAATCACTTAACTTCTCGGTATCTGTTTGTTCCTCCGCACAGTGGGGTTGAT ATCTGGCTTGTCCAGCTCATAGAGTTGTTGTGAGGATCAAATGAGGTTGTATATGTGAAAGGACTTGGAA AAGGGCCGGGATATATTTTCACAGGCTTTTAAGACAGACAGGCTGGCTGGGCACGGTGGCTTATGCCTGT AATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACAGGGTCAGGAGTTTGAGACCAGCCTGGCCAAC ATGGTGAAACCCCGTCTCTACTAAGAATGCGGAAATCAGCCAGGTGTGGTGGCAGGTACCTGTAATCCCA GCTACTCGGGAGGCTGAGGCAGGAGAATGGCTTGAAACTGGAGGGCAGAGATTACAGTGAGCCAAGATCA CTTCACTATACTCCAGCCTGGGCAACAAGAGCAAAACTCCGTCTCAAAAAAAAAACAGACAAACCAAAGC TTGAGGCTTGCATACTGCTTCTGCCATTTACTAACAGCTCACCTCTCTGAACCTGTTTCCCTACTTATTT ATTTATTTATTTTTTTGAGACAGGGTCTCACTCTTGTCTCGCCCAGGCTGGAGTGCAGTTGCGCGATCTC AGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGTGGTTCTTGTGCCTCAGCCTCCCAAGTAGCCGGGATT ACAGGCAGCTGCCACCACACCTGGCTAATTTTTATGTTTTTGGTAGAGATGGGGTTTCTCCATGTTGCCC AGGCTGGTCTTGAACTCCTGGCCTCAAGTGGTCCTCCTGCCTTAGCCTCCCGAAGTGCTGGGATTACAGG TGTGAGCCACTGTGCCAGGCCTTGTTTCCCTACTTATAAGATGGGACCAAATCTTACCTCAGAAGCTTGT GTGAAGATGAATGATCTCGGGTATTTAACGCATGTAGCGCAGTGTCTGGCGTGTTGTACGTGCGCAGTGA ACGATAGTTCTCTGGGTCTCTGTTCTTGCCCCTTGTTTGTCAGCTGGCGTGAGGGCCAGAGGATAAGTTT TTCTCCCTCAAGAAACGAACCAACATTTTCCAAGTTGCTAACTGCTTCTCCATATTAGATTTTTGTTAAT TTTCTGACCAGTGGGTGAGGTGGGATATCAGTTTTGCTTGTTATAGATAATGGGCTAAGACCAGGTGTGA TGGCACATGCCTATTGGGAGGCCAAGGCAAGAAGACTGCATGAGGCCTAGGGAACATAGTGAGGCTCTGT CTCTAAAAAAAAAAAAAAGAAAAAAAAATTAGCTGGGTATAGTGGCATGCACCTGTAGTCCAAAGTACTT GGGAGACTGAGGTGGAAGGATTGCTTGAGCCCAGGAGGTGAGGGTCAAAGCTGCTGCACATGAGCCATGT TTGTGCCACTGCACTCCAGCATGGGCAACAGAGCAAGCCCCTGGCTCTAAAAAATAAAAAAATAATAATG GGCTAAAGCTCAAAGATGTTAAACAACTTGATGCAGTCATACAGCCAGGAAGTAGAGCCTGGACTAGAAC CCACACCTCCTGAATTTAAATTCTGTGTTTTTTTCCATCAGCTCATAAATATGTAAACTAAAGGAAATTG TGGAAACTAACCTTTTGCTTATTTCTTTCAAGTCAACGTTGGTGAGGACTGTCCAGTATTCGATGGCCTG TTTGAGTTCTGTCAGTTGTCTACTGGTGGTTCTGTGGGTAAGGAATATTCATCTTCTCCCCAGGGGTAGA CTGGGTTGTTCTAGTGAGGTCTGCCTTTTAGGCTGCTATCCTAGTTGGCTGATCTGAAACCATGTAGAAT GGTCCTGTGGTTTTTACTGAAGTCTCTAAAATGGCTGGTGTAGTGTCTCACACCTGTAATCCCAGCACTT TGAGAGGCTGAGGAGGAGGATTGCTTGAGGTCAGGAGTTCAAGACCAGCCCAGGCAACATAGACCCTCCT GTCTATAAAAAAATAAAATAAGTAAAAACAATTAGCCGGGCATGGTGACTCGTGCCTGTAGTCCCAGCTA CTCAGGAGGCTGAGGCTTAAACCCAGTAGGTTGAGGCTGCAGTGAGTCGTGGTCACACCACTACACTCTA GCCTGGGCAACAAAGCAAGACCCTGCCTCCAAAAAAAAAATTTAAAAAGCCTCTAAAATGTCCCTCTGGT TCAGTCCCAGCCCAGGTTCAATCTCTGACATGGTACTGACAGGTGTCCTTGACTGTCCTTTCCTACTAAG AGATCTTATGTACAGGCGTTCCCCGCAGACCTCCTGGGGTTGTTAAGATGCTGTACGTAAAAGCAATTTG TGAACTGCAAAGTGCTATAAAAATGGAAGTGTCATCATCTGTGAATCTGTCCTATGAAAAAGTATGGTAA TTACCTTTAGAGGTCAGAAATACTCCTCATGTATCTCCCACTTCCATTTGCAACTTTTGGGTTATCTCCA GGATTACTCTAAACGCTTTCTTAACAAATATTTATTTTCCTGTGATCCCCCACCAATATAATCATTGTGT CCATCCCCGCTGCCCCACCAATATAATCACAGAAAACAAAGAAGTGCACAGAAAAAAACACAATCACCCA CAGTCACAGGGTTGGTGGATAACCTCTGTTACCATGTTGGTGTTTGTATGGCCATTCTTTTGTGTGTGTG TTTATATCTGTGTCACACATATACAACATCTATATTTTACAAAAGTGGGTTATATACATATCACATATAT ATGGTTTTATGCCTGCATTTCCTACTTAACGAAATTGTCTGTAGTTTTCTACAGCTTGCTTTCTTGTGGC TCTATGATTATTCCATGTTGTGGATTTACTTGAGTTGATATAATCTGTCCCTCTTCTTGATAATTTGGAT CAATCTATGCTTTTATTGCTGTTAAAATCAACACTGCAGCTGGACACGGTGGCACATGCCTGTAATCTCA GCACTTTGGGAGGCTGAAGAGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGT GAAACCCCATCTATACTAAAAAATACAAAAATTAGCCGGGCGTGGTGGTGTGTGCCTGTAATCCCAGCTA CTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGCGCC ACTGCACTTCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAAAAACAACAACAAATTAACACTGCCACA AATGCACTTGCACACATGGGTGTGTATTTATCTTTTACTTCTTCTGGGACCTATTCGTGCTAGTGCTTTT TGACCTAGTGTATCAGCACTATCTTTGGTAATTTTTCTTTTTCTTTTTTTTTGAAATAGAGTCTCCCTCC ATCACCCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGAT TCTCCTGCCTCAGCCTCCCCAGGTAGCTGGGACTACAAGTGTATGTCACCACGCCCAGCTAAATTTTTTC GTATTTTTAATAGAGATGAGGTTTAACCATGTTGGCCAGGCTGGTATCGAACTCTTGACCTCAGGTGATG TGCCCGCCTTGGCCTCCCAAACTTCTGGGATTACAGGTGTGAGCCACCGCGCATGGCCTATCTTTGGTAT TTTTTCAAAGTTCCTTGACCATGAGCCATAGTAAGAAATAAATTTACACATGCAATCCAGGATACATATA ACATATGCATGCATGCACACACTCACTCACTCTGAAGCCAGAGTTTTACAAAAGAGCAGTTACCCTTACT GTTACTCTGATATTTTTTTCTATGCTATTTCATTAAAAAAATATATATATATATACACACACACACTAAT CATGATGTACTAAATCAATTTTAAGGCCTGCTAATGGGTTACTACCCTCAGTTTGGAAAATCGTTTTTTA CGAGTAGACAGTATCATGTATTCCCTGCTGAAGTAGGGTGGGAGGGAGGGGACTGGTCTATGAATTGCAC AATACAGCTGTTGAATAGGCAGGTCTTAACCTTTCACTAGGTTCCCTGGGCTTCTTGGAGGAAGGGGAGA GTGGCTTAGTAACAGGCTTATGTTCTCTTTTCTCATGCCCAGCAAGTGCTGTGAAACTTAATAAGCAGCA GACGGACATCGCTGTGAATTGGGCTGGGGGCCTGCACCATGCAAAGAAGTCCGAGGCATCTGGCTTCTGT TACGTCAATGATATCGTCTTGGCCATCCTGGAACTGCTAAAGTATGCCTGCCTGGCCTTGTCTCTTGGAA GAGCACCTTAGGCCAGGTTCCCATTTCCCTCTTCCCCTGGGCTTGCCTCCCTAGTTTGCTTTTCCTACCG ATGTGCTGGCTAGGATGTGCTCGGTGAGTGTCTCTGGCCATCATCTCCTTGATGGGGTCTTGGTTTGATC TGAGCCACGGCATGATCAGGGGCAGATGCTGCTCAGATCCTGCCTCCAGAGTGTCCCTGTGTGGCTGGAG TTGACCCTGGCTGTAGAGTAGGAAGATCGGACTTGGTCGGCTTGGTCAGGCCTCTGGAGACACCCGGCCG CTCTTCCACCTTCCTTCAGCCAGTTTCCACGTCTCTGGTGCTTAGAGATACCTGAGGGAGGCAGCCAGCC CGGTAAGCTGGGAGCTAGCGCCCTTGGCACGTCCCATCCCCAAAGAGCCCCCAGACCCCTGACCCCCTTC TGATCCTAGGTATCACCAGAGGGTGCTGTACATTGACATTGATATTCACCATGGTGACGGCGTGGAAGAG GCCTTCTACACCACGGACCGGGTCATGACTGTGTCCTTTCATAAGTATGGAGAGTACTTCCCAGGAACTG GGGACCTACGGGTGAGAACGCCCTTTAGGAGCCAACCGGCTTACCCTCAGCTGGCAGCTCTACTTCTCTC TCCTATCTCATGCCACTAAAAATTGCTTCTTGCCTCTTCTGCCAATCAGAATACCACATCCCAATCTGAA GCACTTGCCCTGATCTCTTTCCCTTCCTTATTCTGGAGGAAGGGAATGATGGGACATAAAGGGCCAGAGA AAGAAGAGGGGTCTCCTGACTCACTGTACTTTCCTCCTGGCCACAGCTGGGTTGCATCACACTATTCTTA TGTCTCATAAGCCTTGAGTTTGGGGGTAGGAATTGGGACTCTGAAGGACATCTCAAGTGTTCTTCATGTT TTTGGGTCACTTTCCCCTTTAGCCTTTTGACTGAAAACTATGGACTGTCTCTCCAGAAAAGTACATGAGA TTTTACATCTGATATAGAATAGTTAATAGACAAGTCCCCTTACTGAAGCCCATCCATGAACCTTAGGATA AGAATCCTTGGAAGCTACTTCGTTGAACTGTTCCATCTGCTTCTATTAGCATGAATGTGGTGAAATCAGC TGCTTTGCCATGCCTGGTAGCCCTTGGGTAAAAAAGTGGCACTAATTCAGTTGTTTGCCATGGCAAGCGT TAGAATAAATGAGCATTCACTTTTTTTTTTTTTTTGAGACAGTCTCTCTCTGTCACCCAGCCTGGAGTGC AGTGGCGTGATCTCGGTTCACTGCAGCCTCCGCCTCCCGCCTCCAGGCGATCTTGTGCCTCAGCCTCCGA ATAGCCGGGATTTAGCTGGGATTATAAGTGCGTGCAACTATGCCCGGCTAATTTTTGTATTTTTAAAAGA GATGGGGTTTTGCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGATTCACCCGCCTCAGCCTC CCAAAGTGCTGGACTTAAATAGGCGCACTCACTATTTTGAGGTTACTGGGAAGGACTTTCTTACCTCTCT CCTTCCCTCCACAACACCCTAGAGAGGGAGCATGGGGGAAGAGGAGTGAGCATTAGAGCTCTCTGGAGTG GAAAGGGTTGTCAAGGGTGGCTGTCACTTCTGTGACTCACCTGCCAGCCAGCTCTAACCCAATCCCAAGG TAGAAATCTTGTGCTATAGGGTAGGCTATTCAATCTCTGGTCCCATCAAGAGCTCTCAGTCTGGGGGTAG GCTTAATGCTATGTCCAGAGATGATTTGCCAGTGAAGCTAGATTTGCCAGTGAAGAGAATGGTACTAACA AGGTACCTCTGTTCTGTCCTGGCCCACATCATGGGCCTAGCTTGTCTCTCTTGAACCTCTTCCTTTATCC CTCCAGCCCCTATCCTTGACCTTCCTTCAAGCTTCATCCTTCAGTTTTACTTTAATGGCCTTTTTAATTA GGATATCGGGGCTGGCAAAGGCAAGTATTATGCTGTTAACTACCCGCTCCGAGACGGGATTGATGACGAG TCCTATGAGGCCATTTTCAAGCCGGTAAGTGGCTTTATCCACCCCTTGGGCTACAAACAGGGGATTGGTT GGCGGTGGAGGGGAGCAAAGCACCCCCACCATACCTCAGGAATCTCTCCTTACTAAAGCTGGTGGGGAGA TAGAAGTGTTTGAACCCTGGATTGCTGTGTGGTCAGTTAGGGGAACAAACACCCATATTTATTGGTTCCT TCTATGGGTCAGGTCTTCTGCTGGATACAAAAATATCTAAGACATGATCTTTGCCCTCACGGACTATGGT GGGGAAGGCAGGCACATACCCAGTAGTCTATGATTAGTACTGTTTTTGTATCTCCATTTCTTTGGGCTGC TGGGAGATTATTGTGTTCTTTTGGTAGTGGTATGTCTCCTTGGTTTTTTGTGTTCCTCATTGCCTTACAT TGATGTCTGCACATTAGAAGAAGTAGGGACTTACTCCAGTCTTTGCAGACTGGCTTTGTCTGGGAAAGCC CTTTGCCAGTCAGCCCATCCAGAGATTCTGGAAAGGCTGTGTGGCATGTTCCATGGGTAGGCTGGCCTAG TGCCTGTGTTTTTGAGGGATGATCAGAGGAATGAGAGACAAACTACTGCCTGGGCTGGCAGGAGGGTAGC CAGGGATGATTTCACAGAGGTGCTGATGTTTAAGCTGGACTTTGGAAAATGAGGAGGTGCCCATGTGAAG AAGGAGGTGATGGCAGTAAGGGTGGCATTTAGTAGAAGGAATGGCACTAGCAGAAGTGCAGAGGTGCCAG TGTGGCAGCATGTAGGCCAGTGTGGTGTATGGGAGGAGTGCTGAAGGAGGCGGTGGGAAGTGTATGCTGG GCTCAGTATTTCAAAGGGAGCCTTGAATGCCATGCCAAGGAGTTAAATCTTCACTTATAAACAGTAAGAA ACTGCTTAACCTAATAAGGTCAGGTAGTCATTCAGCAAACACTGACTGCCCACTATGTGCCTAGTATTTA ATAAGGGCTACAGAAGTGGGAGTTGTGGTCTCGGTCTCAGTAACGTTAGACTCTGCTTGTGAGAATAAGA TAAACTAAAAGTGCTTGCTCATAATGTAAGGCTTCAAGTCTGTAAGACCGAATGAGTAGAGTAGATGCAG CTAAAGGTCAGGAAGGCTTCCTGGAGGAAGTGGCACTAGAGCTTGGGCAACAGAAGAGACTTAGGGAGTT GAGAGGGAGGCCATTCTAGGTTCAGTGTTACTAGAGTGTTAGAAGGGTCTTAGAGAACTTTTTAAATTGG AAAATTGAAATCCCAAGTGGGCAAGCAAGGGCTCCAGCCTAGCACTCCCTTTTCTCTCCCACATAGCATG AGGGAGAGTGGAAAGGTAGGAGTGGGTGGGAAAGTGTTGCACCCAGCCTTTCCACTCCAAACCTCGTATT GCTTTCTTGAGGTTGGTGGTGACCAGGATGTATCATTTTAGGTCATGTCCAAAGTAATGGAGATGTTCCA GCCTAGTGCGGTGGTCTTACAGTGTGGCTCAGACTCCCTATCTGGGGATCGGTTAGGTTGCTTCAATCTA ACTATCAAAGGTGAGACCAGGTAGCACAAGGATGGGTGGGCGGGGTCCTGCTTGGTGCTCCTGTAACTCA GCACCCCTTCTCCCACCAAAGGACACGCCAAGTGTGTGGAATTTGTCAAGAGCTTTAACCTGCCTATGCT GATGCTGGGAGGCGGTGGTTACACCATTCGTAACGTTGCCCGGTGCTGGACATATGAGACAGCTGTGGCC CTGGATACGGAGATCCCTAATGGTAATAGCTGCAGGGCCAGGTTCGGCTGGGCTGGGTGGGAGCTGGAGC TCATCTGTCCTTAAGTTTATAACCCCTTCCCCGTTGGTCATATGACCGCTCCTCTTCTGATACTAGTCAC TGAGTCTCCTGCCTGTCCTCTTGTGATCAGCAGACCATAACCATCACTTTTTCCCTAGTCCTTTTTAGCT CTCTCCCCTCTCCCTCCTGCTTTTGGTCTGGACAAAGTTCTCATTGGTAATTTACAGCTTTGGAATTTCT ACTCTGTAGAGTAACTGGAGTAGCGAGTGAAGGGAGCGCTCATAATGAGCATGGCCTCAAGTGTCCTAAA CCAGGGACATGGGCCTTCTCCTAGCGACATATACACCACTGGTACAGACATAGGAGAGTGATGTTAAAAA GATGGAAATCCCATAGGTACCCGTGTCTCACAGTGTCTTGGAGGCATTCTCCTCTGTTTGGATAAATAGG CCCAGAGAAACCTACAAATGCTTTAGGGTGCTTACGTGCAAATGGTTAGGGTGCGGTGGCCAGGTCTCTT GACGGTCTTCTCTCCTGCCCCAATCAGAGCTTCCATACAATGACTACTTTGAATACTTTGGACCAGATTT CAAGCTCCACATCAGTCCTTCCAATATGACTAACCAGAACACGAATGAGTACCTGGAGAAGATCAAGTGA GTATATCCTCCAGCCACCCCTTGGTTGAACATTCCTGACTTTGGTTTGTCCCTGACCAGAGCCCTGCTAC TCTCTCCCATTGGCCACAGACAGCGACTGTTTGAGAACCTTAGAATGCTGCCGCACGCACCTGGGGTCCA AATGCAGGCGATTCCTGAGGACGCCATCCCTGAGGAGAGTGGCGATGAGGACGAAGACGACCCTGACAAG CGCATCTCGAGTGAGACCCAGACCTAGAGCCCTATGCCTTCCATTCAATAGGCAGCTCACACTTCCACCA CCATTCCTGGCTGCACACTCCCTCCAAGCTCCCCACCTGTAGAGAAATCTGTTTTCGAGTTCCAGTGCCT GTAGGAACAGGTTAGGGAGCCCGAGTTCCTCCCTCTTCTGGTTCCCTTTCCCTTGGTGTCTCTTGGAGGA CACGCAGGGAAGCACTGGGCATAGATGCTGAGCTAAATCAGCACCCGCCTGCCCTCTCACCCATGCTTCC CACTCCCTCCCAGTCTGCTCCTCTGACAAACGAATTGCCTGTGAGGAAGAGTTCTCCGATTCTGAAGAGG AGGGAGAGGGGGGCCGCAAGAACTCTTCCAACTTCAAAAAAGCCAAGAGAGTCAAAACAGAGGATGAAAA AGAGAAAGACCCAGAGGAGAAGAAAGGTGGGTTTGGGTTCAGCTGGGACTTGGGTCTCGAGCCTGAGAGG ATGAATCTATGTAGGGCAGTGGGAGGAGGGAGTGACTCAGGCCCTGCCAGCTCCTGTGGGGCTCTTCCTC AGTTCCTTGAGCCTTTCAGTGGCTCCCAGAAGTGGCAGAGCCCACAAAACAATGAACCTCTACTGCCTGA GCACGGCTCTCACATACCACCCCAGCCCTTTTCCCAGCACTGCACCCCAGTTTCCCAGGGGGCTGCCTCC GCCCACCAGGTTCTGGCTGTAGCAGGCTGGGAAACCAGTCCAACCTGTTCTCAACAGGGCTCACTGGGAG GACCAGGGATGGGCTTTTCTCTCTTTATGTCCAGTGAGCTGTAGTGTTGGGGAAGGGGTCTCAGGGTAAA TGAAGACCTCATGGGTCTTCCCAGAGGTGCTGCCCTTGGCCATCCCTGTACTCTTGTGTTCTAGAAGTCA CCGAAGAGGAGAAAACCAAGGAGGAGAAGCCAGAAGCCAAAGGGTGAGGAAGGAGCTGCCTGTGGCCATC TCCCTGGCATTGGAGCACCAGCCCCTTTGTCCCACCACTCTGAGGAAAGGCACAGGGACAGCTGGTCCAG CTTACAAAGGCCTCTTTCAGGGACCAGTCTGTCCAGCTCTGCAGTTCTAGGCAGAGCTAGGAGCCCCAGC CCCCAGTAGTCACCTAGGATCCTGTGGAAGTCACTGTCTGCACTTTTGCCCTGAGGCTCTGGGCTGGGTC ATCTCATGCCAGTCTCTGCTCTCTCCACAGGGTCAAGGAGGAGGTCAAGTTGGCCTGAATGGACCTCTCC AGCTCTGGCTTCCTGCTGAGTCCCTCACGTTTCTTCCCCAACCCCTCAGATTTTATATTTTCTATTTCTC TGTGTATTTATATAAAAATTTATTAAATATAAATATCCCCAGGGACAGAAACCAAGGCCCCGAGCTCAGG GCAGCTGTGCTGGGTGAGCTCTTCCAGGAGCCACCTTGCCACCCATTCTTCCCGTTCTTAACTTTGAACC ATAAAGGGTGCCAGGTCTGGGTGAAAGGGATACTTTTATGCAACCATAAGACAAACTCCTGAAATGCCAA GTGCCTGCTTAGTAGCTTTGGAAAGGTGCCCTTATTGAACATTCTAGAAGGGGTGGCTGGGTCTTCAAGG ATCTCCTGTTTTTTTCAGGCTCCTAAAGTAACATCAGCCATTTTTAGATTGGTTCTGTTTTCGTACCTTC CCACTGGCCTCAAGTGAGCCAAGAAACACTGCCTGCCCTCTGTCTGTCTTCTCCTAATTCTGCAGGTGGA GGTTGCTAGTCTAGTTTCCTTTTTGAGATACTATTTTCATTTTTGTGAGCCTCTTTGTAATAAAATGGTA CATTTCTATATC    Download   Select all
Length	41522
OMIM ID	601241
HGNC ID	HGNC:4852
Unigene ID	Hs.88556
Ensembl ID	ENSG00000116478
PharmGKB ID	-

mRNA Information

mRNA ID	NM_004964.2
Exon	join(1..112,10515..10627,24559..24676,32373..32447, 34833..34971,35430..35571,36962..37054,38472..38580, 38662..38802,39368..39476,39570..39700,39984..40136, 40595..40643,40911..41517)
mRNA Sequence	>3065 GAGCGGAGCCGCGGGCGGGAGGGCGGACGGACCGACTGACGGTAGGGACGGGAGGCGAGCAAGA TGGCGCAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGGGATGTTGGAAATTA CTATTATGGACAAGGCCACCCAATGAAGCCTCACCGAATCCGCATGACTCATAATTTGCTGCTC AACTATGGTCTCTACCGAAAAATGGAAATCTATCGCCCTCACAAAGCCAATGCTGAGGAGATGA CCAAGTACCACAGCGATGACTACATTAAATTCTTGCGCTCCATCCGTCCAGATAACATGTCGGA GTACAGCAAGCAGATGCAGAGATTCAACGTTGGTGAGGACTGTCCAGTATTCGATGGCCTGTTT GAGTTCTGTCAGTTGTCTACTGGTGGTTCTGTGGCAAGTGCTGTGAAACTTAATAAGCAGCAGA CGGACATCGCTGTGAATTGGGCTGGGGGCCTGCACCATGCAAAGAAGTCCGAGGCATCTGGCTT CTGTTACGTCAATGATATCGTCTTGGCCATCCTGGAACTGCTAAAGTATCACCAGAGGGTGCTG TACATTGACATTGATATTCACCATGGTGACGGCGTGGAAGAGGCCTTCTACACCACGGACCGGG TCATGACTGTGTCCTTTCATAAGTATGGAGAGTACTTCCCAGGAACTGGGGACCTACGGGATAT CGGGGCTGGCAAAGGCAAGTATTATGCTGTTAACTACCCGCTCCGAGACGGGATTGATGACGAG TCCTATGAGGCCATTTTCAAGCCGGTCATGTCCAAAGTAATGGAGATGTTCCAGCCTAGTGCGG TGGTCTTACAGTGTGGCTCAGACTCCCTATCTGGGGATCGGTTAGGTTGCTTCAATCTAACTAT CAAAGGACACGCCAAGTGTGTGGAATTTGTCAAGAGCTTTAACCTGCCTATGCTGATGCTGGGA GGCGGTGGTTACACCATTCGTAACGTTGCCCGGTGCTGGACATATGAGACAGCTGTGGCCCTGG ATACGGAGATCCCTAATGAGCTTCCATACAATGACTACTTTGAATACTTTGGACCAGATTTCAA GCTCCACATCAGTCCTTCCAATATGACTAACCAGAACACGAATGAGTACCTGGAGAAGATCAAA CAGCGACTGTTTGAGAACCTTAGAATGCTGCCGCACGCACCTGGGGTCCAAATGCAGGCGATTC CTGAGGACGCCATCCCTGAGGAGAGTGGCGATGAGGACGAAGACGACCCTGACAAGCGCATCTC GATCTGCTCCTCTGACAAACGAATTGCCTGTGAGGAAGAGTTCTCCGATTCTGAAGAGGAGGGA GAGGGGGGCCGCAAGAACTCTTCCAACTTCAAAAAAGCCAAGAGAGTCAAAACAGAGGATGAAA AAGAGAAAGACCCAGAGGAGAAGAAAGAAGTCACCGAAGAGGAGAAAACCAAGGAGGAGAAGCC AGAAGCCAAAGGGGTCAAGGAGGAGGTCAAGTTGGCCTGAATGGACCTCTCCAGCTCTGGCTTC CTGCTGAGTCCCTCACGTTTCTTCCCCAACCCCTCAGATTTTATATTTTCTATTTCTCTGTGTA TTTATATAAAAATTTATTAAATATAAATATCCCCAGGGACAGAAACCAAGGCCCCGAGCTCAGG GCAGCTGTGCTGGGTGAGCTCTTCCAGGAGCCACCTTGCCACCCATTCTTCCCGTTCTTAACTT TGAACCATAAAGGGTGCCAGGTCTGGGTGAAAGGGATACTTTTATGCAACCATAAGACAAACTC CTGAAATGCCAAGTGCCTGCTTAGTAGCTTTGGAAAGGTGCCCTTATTGAACATTCTAGAAGGG GTGGCTGGGTCTTCAAGGATCTCCTGTTTTTTTCAGGCTCCTAAAGTAACATCAGCCATTTTTA GATTGGTTCTGTTTTCGTACCTTCCCACTGGCCTCAAGTGAGCCAAGAAACACTGCCTGCCCTC TGTCTGTCTTCTCCTAATTCTGCAGGTGGAGGTTGCTAGTCTAGTTTCCTTTTTGAGATACTAT TTTCATTTTTGTGAGCCTCTTTGTAATAAAATGGTACATTTCT    Download   Select all
Length	2091

CDS Information

   

Location	join(64..112,10515..10627,24559..24676,32373..32447, 34833..34971,35430..35571,36962..37054,38472..38580, 38662..38802,39368..39476,39570..39700,39984..40136, 40595..40643,40911..40938)
CDS Sequence	>gi|13128859:64-1512 Homo sapiens histone deacetylase 1 (HDAC1), mRNA ATGGCGCAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGGGATGTTGGAAATTACTATT ATGGACAAGGCCACCCAATGAAGCCTCACCGAATCCGCATGACTCATAATTTGCTGCTCAACTATGGTCT CTACCGAAAAATGGAAATCTATCGCCCTCACAAAGCCAATGCTGAGGAGATGACCAAGTACCACAGCGAT GACTACATTAAATTCTTGCGCTCCATCCGTCCAGATAACATGTCGGAGTACAGCAAGCAGATGCAGAGAT TCAACGTTGGTGAGGACTGTCCAGTATTCGATGGCCTGTTTGAGTTCTGTCAGTTGTCTACTGGTGGTTC TGTGGCAAGTGCTGTGAAACTTAATAAGCAGCAGACGGACATCGCTGTGAATTGGGCTGGGGGCCTGCAC CATGCAAAGAAGTCCGAGGCATCTGGCTTCTGTTACGTCAATGATATCGTCTTGGCCATCCTGGAACTGC TAAAGTATCACCAGAGGGTGCTGTACATTGACATTGATATTCACCATGGTGACGGCGTGGAAGAGGCCTT CTACACCACGGACCGGGTCATGACTGTGTCCTTTCATAAGTATGGAGAGTACTTCCCAGGAACTGGGGAC CTACGGGATATCGGGGCTGGCAAAGGCAAGTATTATGCTGTTAACTACCCGCTCCGAGACGGGATTGATG ACGAGTCCTATGAGGCCATTTTCAAGCCGGTCATGTCCAAAGTAATGGAGATGTTCCAGCCTAGTGCGGT GGTCTTACAGTGTGGCTCAGACTCCCTATCTGGGGATCGGTTAGGTTGCTTCAATCTAACTATCAAAGGA CACGCCAAGTGTGTGGAATTTGTCAAGAGCTTTAACCTGCCTATGCTGATGCTGGGAGGCGGTGGTTACA CCATTCGTAACGTTGCCCGGTGCTGGACATATGAGACAGCTGTGGCCCTGGATACGGAGATCCCTAATGA GCTTCCATACAATGACTACTTTGAATACTTTGGACCAGATTTCAAGCTCCACATCAGTCCTTCCAATATG ACTAACCAGAACACGAATGAGTACCTGGAGAAGATCAAACAGCGACTGTTTGAGAACCTTAGAATGCTGC CGCACGCACCTGGGGTCCAAATGCAGGCGATTCCTGAGGACGCCATCCCTGAGGAGAGTGGCGATGAGGA CGAAGACGACCCTGACAAGCGCATCTCGATCTGCTCCTCTGACAAACGAATTGCCTGTGAGGAAGAGTTC TCCGATTCTGAAGAGGAGGGAGAGGGGGGCCGCAAGAACTCTTCCAACTTCAAAAAAGCCAAGAGAGTCA AAACAGAGGATGAAAAAGAGAAAGACCCAGAGGAGAAGAAAGAAGTCACCGAAGAGGAGAAAACCAAGGA GGAGAAGCCAGAAGCCAAAGGGGTCAAGGAGGAGGTCAAGTTGGCCTGA    Download   Select all
CCDS ID	CCDS360.1

Protein Information

      

Protein ID	NP_004955.2
Protein Name	Histone deacetylase 1
Molecular Wt. (Da)	54972
Protein Sequence	>3065 MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEM TKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQ TDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDR VMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSA VVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVAL DTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAI PEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDE KEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA    Download   Select all
Length	482
Uniprot ID	P00915
Ensembl Protein ID	ENSP00000392338

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
K	Sumoylation	444
S	Phosphorylation	421
S	Phosphorylation	423
S	Phosphorylation	421
S	Phosphorylation	423
Y	Phosphorylation	221;-
S	Phosphorylation	421;-
S	Phosphorylation	393;-
S	Phosphorylation	406
S	Phosphorylation	409
S	Phosphorylation	410
K	Acetylation	89
K	Acetylation	220
K	Acetylation	74
K	Acetylation	361
Y	Phosphorylation	222
Y	Phosphorylation	226
Y	Phosphorylation	237

Enzyme Information

   

EC	3.5.1.98
Name	histone deacetylase HDAC
Class	Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides
Sysname
Substrate
Product
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
367	AR	2437	NP_000035.2	in vitro;in vivo	11994312
546	ATRX	2069	NP_000480.2	in vivo	14645126
672	BRCA1	218	NP_009231.2	in vitro;in vivo	10220405
699	BUB1	3907	NP_004327.1	in vitro	15388328
701	BUB1B	4176	NP_001202.4	in vitro	15388328
864	RUNX3	2565	AAH13362.1	in vitro;in vivo	15138260
991	CDC20	4686	NP_001246.2	in vitro	15388328
999	CDH1	1885	BAA88957.1	in vitro	15388328
1643	DDB2	2886	NP_000098.1	in vitro	8602529
1786	DNMT1	532	NP_001124295.1	in vitro;in vivo	10615135
2122	MECOM	1310	NP_001098547.3	in vitro;in vivo	11568182
2287	FKBP3	1743	NP_002004.1	in vitro;in vivo	11532945
2290	FOXG1	1283	NP_005240.3	in vitro;in vivo	11238932
4193	MDM2	1272	NP_002383.2	in vivo	12426395
4654	MYOD1	1166	NP_002469.2	in vitro	1   128   523   711   684   020
4790	NFKB1	1238	NP_003989.2	in vitro;in vivo	1   193   176   914   678   980
4792	NFKBIA	1235	NP_065390.1	in vivo	12972430
5111	PCNA	1456	NP_002583.1	in vitro;in vivo	11929879
5245	PHB	1454	NP_002625.1	in vivo	12466959
5371	PML	23	NP_150241.2	in vitro;in vivo	1   143   082   611   259   570
5467	PPARD	2679	NP_006229.1	in vivo	11867749
5757	PTMA	1778	NP_001092755.1	in vitro	12634383
5925	RB1	1574	NP_000312.2	in vivo	9   491   888   108   888   860   000   000   000   000   000   000   000
5926	ARID4A	1575	NP_002883.3	in vivo	10490602
5933	RBL1	312	NP_002886.2	in vitro;in vivo	9724731
5934	RBL2	1576	NP_005602.3	in vitro;in vivo	972   473   110   969   803
5970	RELA	1241	NP_068810.3	in vitro;in vivo	11564889
5981	RFC1	24	NP_002904.3	in vitro;in vivo	12045192
5984	RFC4	22	NP_002907.1	in vitro	12045192
6667	SP1	1796	NP_612482.2	in vitro;in vivo	118   966   131   190   996   000   000   000
6774	STAT3	26	NP_644805.1	in vivo	15653507
6839	SUV39H1	2221	NP_003164.1	in vitro;in vivo	1   178   871   010   873   450
6886	TAL1	1753	NP_003180.1	in vitro;in vivo	10688671
7026	NR2F2	139	NP_066285.1	in vitro	10704340
7050	TGIF1	4023	NP_733796.2	in vitro;in vivo	1   122   616   318   511   900
7153	TOP2A	536	NP_001058.2	in vitro;in vivo	11136718
7155	TOP2B	537	NP_001059.2	in vitro;in vivo	11136718
7164	TPD52L1	7236	NP_003278.1	yeast 2-hybrid	16169070
8379	MAD1L1	4065	NP_003541.2	in vitro	15388328
9612	NCOR2	2910	NP_006303.3	in vivo	11739383
9643	MORF4L2	2326	NP_036418.1	in vitro;in vivo	14506250
10856	RUVBL2	16070	NP_006657.1	in vitro;in vivo	15829968
23013	SPEN	10230	NP_055816.2	in vivo	11331609
23309	SIN3B	9691	NP_056075.1	in vitro	11959842
29843	SENP1	7153	NP_055369.1	in vitro;in vivo	15199155

Pathway Information

                                                                              

Pathway Name	Pathway ID
Alcoholism	hsa05034
Amphetamine addiction	hsa05031
Cell cycle	hsa04110
Chronic myeloid leukemia	hsa05220
Epstein-Barr virus infection	hsa05169
Huntington's disease	hsa05016
Longevity regulating pathway - multiple species	hsa04213
MicroRNAs in cancer	hsa05206
Notch signaling pathway	hsa04330
Pathways in cancer	hsa05200
Thyroid hormone signaling pathway	hsa04919
Transcriptional misregulation in cancer	hsa05202
Viral carcinogenesis	hsa05203

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd10010	4-374	HDAC1
cl17011	4-374	Arginase_HDAC superfamily
cd10011	8-373	HDAC2
cd10005	9-387	HDAC3
cd09991	14-319	HDAC_classI
cd10004	8-382	RPD3-like
cd11598	11-319	HDAC_Hos2
cd10000	29-370	HDAC8
cd09301	34-319	HDAC
COG0123	13-340	AcuC
cd09994	12-313	HDAC_AcuC_like
pfam00850	22-320	Hist_deacetyl
cd11680	34-319	HDAC_Hos1
PTZ00346	15-325	PTZ00346
cd09992	28-311	HDAC_classII
cd09993	28-310	HDAC_classIV
cd09996	26-340	HDAC_classII_1
cd10001	27-311	HDAC_classII_APAH
cd09987	107-319	Arginase_HDAC
cd10002	24-311	HDAC10_HDAC6-dom1
cd10003	27-325	HDAC6-dom2
cd11600	27-329	HDAC_Clr3
cd11681	28-284	HDAC_classIIa
cd10008	28-301	HDAC7
cd10006	28-301	HDAC4
cd10007	28-281	HDAC5
cd11599	28-277	HDAC_classII_2
cd10009	20-281	HDAC9
cd11682	28-309	HDAC6-dom1
cd11683	32-316	HDAC10
cd09998	140-185	HDAC_Hos3
PTZ00063	7-387	PTZ00063

Ontology Information

   

HPRD ID	265
Molecular Class	Transcription regulatory protein
Molecular Function	Catalytic activity (GO:0003824)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report