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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
HDAC3 8841 histone deacetylase 3  5RPD3, HD3, RPD3-2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
17849419   2008Cell line : HT29,SW480

Source : -

Sample Type : -

No. of Sample : -

Stage : -

ImmunohistochemistryUp-regulation--


Gene Details



NC_000005.9 (141000443..141016423, complement)

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Gene Type protein coding
Gene Family -
Description Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]  
Chromosome 5
Location 5q31.1-q31
Start 141000443  
End 141016423  
Strand -  
Gene Sequence

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Length 15981  
OMIM ID 605166   
HGNC ID HGNC:4854   
Unigene ID Hs.519632   
Ensembl ID ENSG00000171720   
PharmGKB ID PA29228   

mRNA Information


mRNA ID ?NM_003883.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS4264.1



Protein Information


      
Protein IDNP_003874.2
Protein Namehistone deacetylase 3
Molecular Wt. (Da)0
Protein Sequence

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Length 428  
Uniprot IDQ9Y5W5
Ensembl Protein ID ENSP00000286574  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation424
YPhosphorylation404;-
SPhosphorylation405;-

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
595CCND11346NP_444284.1in vivo12048199   
860RUNX22566NP_001019801.3in vitro;in vivo15292260   
863CBFA2T34847NP_005178.4in vivo12242670   
2624GATA2673NP_116027.2in vitro;in vivo;yeast 2-hybrid11567998   
2969GTF2I3399NP_127492.1in vitro;in vivo1   239   388   712   239   340   
3065HDAC13143NP_004955.2in vitro1   094   411   711   302   700   
3725JUN1302NP_002219.1in vivo12853483   
4152MBD11133NP_056671.2in vivo16432238   
4792NFKBIA1235NP_065390.1in vivo12972430   
5467PPARD2679NP_006229.1in vivo11867749   
5468PPARG3288NP_056953.2in vivo12479814   
5531PPP4C3615NP_002711.1in vivo15805470   
5600MAPK114208AAB05036.1in vitro;in vivo;yeast 2-hybrid15356147   
5925RB11574NP_000312.2in vivo12479814   
5926ARID4A1575NP_002883.3in vivo10490602   
5928RBBP44232NP_005601.1in vitro;in vivo1   177   790   511   470   860   
5970RELA1241NP_068810.3in vitro;in vivo1   241   980   611   533   480   
6774STAT326NP_644805.1in vivo15653507   
6839SUV39H12221NP_003164.1in vitro;in vivo11788710   
6907TBL1X2183NP_005638.1in vitro;in vivo108   096   641   094   411   000   000   000   
7181NR2C13318NP_003288.2in vitro;in vivo114   638   561   452   192   000   000   000   
7464CORO2A3695NP_003380.3in vitro12628926   
7514XPO13975NP_003391.1in vivo11779848   
7528YY12482NP_003394.1in vitro9346952   
8204NRIP13927NP_003480.2in vitro;in vivo1   100   627   517   053   780   
8764TNFRSF144122NP_003811.2in vivo11463856   
9063PIAS26944NP_004662.2in vitro12239342   
9569GTF2IRD18379NP_057412.1in vitro12239342   
9611NCOR12911NP_006302.2in vitro;in vivo;yeast 2-hybrid1   094   411   711   509   650   000   000   000   000   000   000   000   000   
9612NCOR22910NP_006303.3in vitro118   045   851   094   411   000   000   000   
9734HDAC95944NP_848512.1in vitro;in vivo125   901   351   065   548   000   000   000   
9759HDAC45610NP_006028.2in vitro;in vivo11466315   
9989PPP4R15366AAL78298.1in vitro;in vivo15805470   
22948CCT56468NP_036205.1in vivo12502735   
23118MAP3K7IP25483NP_055908.1in vitro12150997   
54880BCOR6458NP_001116857.1in vivo10898795   
55806HR3808NP_005135.2in vivo;yeast 2-hybrid11641275   
150572SMYD16025NP_938015.1in vivo11923873   


Pathway Information


                  
Pathway Name Pathway ID
Alcoholism hsa05034
Thyroid hormone signaling pathway hsa04919
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd100053-383  HDAC3
cl170113-383  Arginase_HDAC superfamily
cd099918-314  HDAC_classI
cd100043-378  RPD3-like
cd100103-369  HDAC1
cd100113-369  HDAC2
cd115985-314  HDAC_Hos2
cd100005-367  HDAC8
COG01233-335  AcuC
cd099946-308  HDAC_AcuC_like
pfam0085016-314  Hist_deacetyl
cd1168028-314  HDAC_Hos1
PTZ003464-314  PTZ00346
cd0930128-314  HDAC
cd0999222-306  HDAC_classII
cd099968-348  HDAC_classII_1
cd1000162-306  HDAC_classII_APAH
cd0999322-305  HDAC_classIV
cd1160021-305  HDAC_Clr3
cd1000221-328  HDAC10_HDAC6-dom1
cd1159922-272  HDAC_classII_2
cd100039-314  HDAC6-dom2
cd09987101-312  Arginase_HDAC
cd11681134-318  HDAC_classIIa
cd10007134-318  HDAC5
cd10006134-296  HDAC4
cd10008134-318  HDAC7
cd1168220-304  HDAC6-dom1
cd10009134-261  HDAC9
cd1168326-313  HDAC10
cd09998134-179  HDAC_Hos3
PTZ000631-397  PTZ00063


Ontology Information


   
HPRD ID5733
Molecular ClassTranscription regulatory protein
Molecular FunctionSerine-type peptidase activity (GO:0008236)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
O15379DB02546VorinostatSmallMoleculeDrug
O15379DB06603PanobinostatSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO