Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
HDAC5 10014 histone deacetylase 5  17KIAA0600, NY-CO-9, FLJ90614 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26131280   2015Cell line : SW480, HCT116, SW620

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Cell viability assay,realtime RT-PCR,Western blotting Up-regulation-HDAC5 elevates the proliferation of colorectal cancer cells through up-regulation of DLL4. The current study might provide novel potential therapeutic targets in the treatment of colorectal cancer.


Gene Details



NC_000017.10 (42154121..42201014, complement)

View Larger Image
   
Gene Type protein coding
Gene Family -
Description Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 17
Location 17q21
Start 42154121  
End 42201014  
Strand -  
Gene Sequence

   Download   Select all

Length 46894  
OMIM ID 605315   
HGNC ID HGNC:14068   
Unigene ID Hs.438782   
Ensembl ID -   
PharmGKB ID PA29230   

mRNA Information


mRNA ID ?NM_001015053.1
Exon  
mRNA Sequence

   Download   Select all

Length  



CDS Information


   
Location
CDS Sequence

   Download   Select all

CCDS ID CCDS32663.1



Protein Information


      
Protein IDNP_001015053.1
Protein Namehistone deacetylase 5
Molecular Wt. (Da)0
Protein Sequence

   Download   Select all

Length 1122  
Uniprot IDQ9BY67
Ensembl Protein ID ENSP00000329797  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation259
SPhosphorylation498
SPhosphorylation260
SPhosphorylation499
SPhosphorylation259
SPhosphorylation498
SPhosphorylation260
SPhosphorylation499
KAcetylation533
KAcetylation534

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
604BCL6180NP_620309.1in vitro;in vivo11929873   
864RUNX32565AAH13362.1in vitro;in vivo15138260   
2623GATA12372NP_002040.1in vitro;in vivo14668799   
2624GATA2673NP_116027.2in vitro;in vivo11567998   
2810SFN3185NP_006133.1in vivo;yeast 2-hybrid15367659   
4205MEF2A2807NP_005578.2in vitro;in vivo1   074   809   810   737   770   
4208MEF2C2809NP_002388.2in vitro10737771   
4209MEF2D2810NP_005911.1in vitro;in vivo1   289   697   010   737   770   
4261CIITA2475NP_000237.2in vivo15964851   
6839SUV39H12221NP_003164.1in vivo12242305   
7316UBC7038NP_066289.2in vitro;in vivo12354939   
7529YWHAB3184NP_003395.1in vivo10869435   
7531YWHAE5457NP_006752.1in vitro;in vivo;yeast 2-hybrid1   086   943   511   114   190   
8625RFXANK4435NP_003712.1in vitro;in vivo15964851   
8841HDAC38950NP_003874.2in vitro;in vivo102   203   851   180   458   000   000   000   
9611NCOR12911NP_006302.2in vitro;yeast 2-hybrid10640275   
9612NCOR22910NP_006303.3in vitro;in vivo;yeast 2-hybrid10869435   
11218DDX205859NP_009135.4in vitro;in vivo12007404   
11337GABARAP5496NP_009209.1yeast 2-hybrid16169070   
23468CBX55131NP_036249.1in vitro12242305   
54880BCOR6458NP_001116857.1in vivo10898795   
55806HR3808NP_005135.2in vivo;yeast 2-hybrid11641275   
57763ANKRA212044NP_075526.1in vitro;in vivo15964851   


Pathway Information


                  
Pathway Name Pathway ID
Alcoholism hsa05034
Epstein-Barr virus infection hsa05169
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd10007679-1095  HDAC5
cl17011679-1095  Arginase_HDAC superfamily
cd1016468-164  ClassIIa_HDAC5_Gln-rich-N
cl1361468-164  ClassIIa_HDAC_Gln-rich-N superfamily
cd11681681-1058  HDAC_classIIa
cd10006678-1087  HDAC4
cd10008681-1058  HDAC7
cd10009681-1058  HDAC9
cd10003687-1060  HDAC6-dom2
cd09992704-1023  HDAC_classII
cd11600704-1024  HDAC_Clr3
pfam00850704-1023  Hist_deacetyl
cd10002704-1058  HDAC10_HDAC6-dom1
cd09301710-1022  HDAC
cd11682704-1058  HDAC6-dom1
cd11599704-1023  HDAC_classII_2
cd09996683-1009  HDAC_classII_1
COG0123683-1033  AcuC
cd11683710-1058  HDAC10
cd10001704-1024  HDAC_classII_APAH
cd09994704-1008  HDAC_AcuC_like
cd10000697-1012  HDAC8
cd09993714-996  HDAC_classIV
cd11680832-1012  HDAC_Hos1
cd09991697-996  HDAC_classI
cd11598733-988  HDAC_Hos2
cd09987795-1022  Arginase_HDAC
cd10004699-985  RPD3-like
cd10010704-985  HDAC1
cd09998812-1022  HDAC_Hos3
cd10005699-987  HDAC3
cd10011704-985  HDAC2
PTZ00346832-1005  PTZ00346
cd1014968-164  ClassIIa_HDAC_Gln-rich-N
pfam1220367-164  HDAC4_Gln
cd1016368-133  ClassIIa_HDAC9_Gln-rich-N
cd1016268-133  ClassIIa_HDAC4_Gln-rich-N
PTZ00063832-996  PTZ00063


Ontology Information


   
HPRD ID5049
Molecular ClassTranscription regulatory protein
Molecular FunctionATPase activity (GO:0016887)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q9UQL6DB06603PanobinostatSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO