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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HES1 | 3280 | hes family bHLH transcription factor 1 | 3 | FLJ20408, HES-1, Hes1, bHLHb39 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25636905 | 2015 | Cell line : RKO, HCT8, LOVO Source : Sixth Affiliated Hospital of Sun Yat Sen University China. Sample Type : CRC tumor and normal tissues No. of Sample : 320 Stage : - | Immunohistochemistry,Western Blotting Immunoflourescentce, Transfection | Up-regulation | - | HES1 enhanced invasiveness and metastasis of CRC cells. HES1 promotes cancer metastasis via inducing epithelial mesenchymal transition and serves as a poor prognosis factor of colorectal cancer patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Basic helix-loop-helix proteins |
| Description | This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008] | Chromosome | 3 |
| Location | 3q28-q29 |
| Start | 193853931 |
| End | 193856401 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 2471 |
| OMIM ID | 139605 |
| HGNC ID | HGNC:5192 |
| Unigene ID | Hs.250666 |
| Ensembl ID | ENSG00000114315 |
| PharmGKB ID | PA29465 |
mRNA Information
| mRNA ID | NM_005524.3 |
|---|---|
| Exon | join(1..347,476..571,820..907,1542..2471) | mRNA Sequence | Download Select all |
| Length | 1475 |
Protein Information
| Protein ID | NP_005515.1 |
|---|---|
| Protein Name | hes family bHLH transcription factor 1 |
| Molecular Wt. (Da) | 29410 |
| Protein Sequence | Download Select all |
| Length | 280 |
| Uniprot ID | O14521 |
| Ensembl Protein ID | ENSP00000364699 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 37 |
| S | Phosphorylation | 38 |
| S | Phosphorylation | 10 |
| T | Phosphorylation | 24 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2175 | FANCA | 6186 | NP_000126.2 | in vivo;yeast 2-hybrid | 18550849 |
| 2178 | FANCE | 2943 | NP_068741.1 | in vivo;yeast 2-hybrid | 18550849 |
| 2188 | FANCF | 4589 | NP_073562.1 | in vivo;yeast 2-hybrid | 18550849 |
| 2189 | FANCG | 4262 | NP_004620.1 | in vivo;yeast 2-hybrid | 18550849 |
| 3397 | ID1 | 8980 | NP_002156.2 | in vivo;yeast 2-hybrid | 11756408 |
| 3398 | ID2 | 2664 | NP_002157.2 | in vivo;yeast 2-hybrid | 11756408 |
| 3399 | ID3 | 2608 | NP_002158.3 | yeast 2-hybrid | 11756408 |
| 3400 | ID4 | 8995 | NP_001537.1 | yeast 2-hybrid | 11756408 |
| 3717 | JAK2 | 993 | NP_004963.1 | in vitro;in vivo | 15156153 |
| 55120 | FANCL | 6997 | NP_001108108.1 | in vivo;yeast 2-hybrid | 18550849 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Fanconi anemia pathway | hsa03460 |
| Maturity onset diabetes of the young | hsa04950 |
| Notch signaling pathway | hsa04330 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00083 | 32-95 | HLH |
| cl00081 | 32-95 | HLH superfamily |
| pfam07527 | 109-150 | Hairy_orange |
| cl02638 | 109-150 | Hairy_orange superfamily |
| smart00511 | 109-150 | ORANGE |
| pfam00010 | 35-92 | HLH |
| smart00353 | 40-97 | HLH |
Ontology Information
| HPRD ID | 7532 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Binding (GO:0005488) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.