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General Information
- Evidence
- Gene
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17683069 | 2007 | Cell line : Colo 205, Colo 320, HT 29 Source : ATCC Sample Type : CRC tumor and normal tissue No. of Sample : 10 Stage : TNM Stage I-III | real time RT-PCR, Western blotting, Transfection experiments. | Down-regulation | - | HHIP expression has been shown to be reduced in 8/10 primary human colon cancers, when compared with the normal tissue from the same patient. |
| 17089004 | 2006 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Methylation | - | Hedgehog signaling molecules or targets, such as SHH, IHH, HHIP1, PTCH1 and GLI1, are applied as biomarkers for cancer diagnostics, prognostics and therapeutics. Hedgehog signaling is frequently activated in esophageal cancer, gastric cancer and pancreatic cancer due to transcriptional upregulation of Hedgehog ligands and epigenetic silencing of HHIP1/HHIP gene, encoding the Hedgehog inhibitor. |
| 17724792 | 2007 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR, tissue microarray analysis, methylation-specific PCR, and chromatin immunoprecipitation assay | Methylation | - | Silencing of the HHIP gene due to hypermethylation and chromatin remodelling appears to be frequently involved in gastrointestinal tumourigenesis. |
| 17461467 | 2007 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 25 colorectal adeno-carcinomas Stage : - | real time RT-PCR, in situ hybridization and immunohistochemistry | Up-regulation | - | Expression of Ptch1, Hip and Gli1 were mainly detected in the malignant crypts of adenocarcinomas. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011] | Chromosome | 4 |
| Location | 4q28-q32 |
| Start | 144645996 |
| End | 144741400 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 95405 |
| OMIM ID | 606178 |
| HGNC ID | HGNC:14866 |
| Unigene ID | Hs.507991 |
| Ensembl ID | ENSG00000164161 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_022475.2 |
|---|---|
| Exon | join(1..959,6610..6802,12795..12951,13642..13843, 60536..60687,61092..61265,62173..62316,65955..66076, 68230..68353,69305..69435,72880..72961,88746..88894, 91769..92734) | mRNA Sequence | Download Select all |
| Length | 3555 |
CDS Information
| Location | join(681..959,6610..6802,12795..12951,13642..13843, 60536..60687,61092..61265,62173..62316,65955..66076, 68230..68353,69305..69435,72880..72961,88746..88894, 91769..91893,92724..92738) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_071920.1 |
|---|---|
| Protein Name | Hedgehog interacting protein |
| Molecular Wt. (Da) | 77008 |
| Protein Sequence | Download Select all |
| Length | 700 |
| Uniprot ID | Q12946 |
| Ensembl Protein ID | ENSP00000262426 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| cAMP signaling pathway | hsa04024 |
| Hedgehog signaling pathway | hsa04340 |
| Pathways in cancer | hsa05200 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03024 | 38-220 | Folate_rec |
| cl03844 | 38-220 | Folate_rec superfamily |
| pfam07995 | 237-432 | GSDH |
| COG2133 | 219-432 | YliI |
| TIGR03606 | 278-432 | non_repeat_PQQ |
Ontology Information
| HPRD ID | 645 |
|---|---|
| Molecular Class | Integral membrane protein |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.