Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HIC1 | 3090 | Hypermethylated in cancer 1 | 17 | hic-1; ZBTB29; ZNF901 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20682398 | 2010 | Cell line : - Source : Department of Medical Oncology in the Faculty of Medicine at Akdeniz University. Sample Type : CRC tumor and normal tissue No. of Sample : 17 CRC and 20 healthy controls Stage : - | PCR and reverse-hybridization methods | Methylation | - | HIC1 gene, overall promoter methylation was demonstrated in three tumor, while Partial promoter methylation was noted in two normal; however, no methylation existed in normal. |
| 21274674 | 2011 | Cell line : - Source : Endoscopy unit, Tropical Medicine Department, Kasr AlAini Hospital, Cairo University Sample Type : CRC tumor and normal tissue No. of Sample : 72 patients (36 CRC, 17 adenomatous polyps, and 19 ulcerative colitis), and adjacent normal tissues Stage : - | Methylation-specific PCR | Methylation | - | Hypermethylation of MGMT and HIC-1 genes plays an important role in the initiation of disease especially ulcerative colitis-carcinoma pathway. |
| 22020530 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : CRC 30 and 30 adenomatous polyps Stage : TNM Stage I,II | Array-mediated analysis methylation profiling | Methylation | - | Three promoters (HIC1, MDG1 and RASSF1A) were selected for the biomarker, which differentiated patients with adenomatous polyps and controls. Methylation profiling of plasma DNA can detect early CRC with significant accuracy. So these marker can be used as epigenetic biomarker for CRC. |
| 23010642 | 2012 | Cell line : - Source : CRC tissue in Saudi Arabian patients. Sample Type : Case control study No. of Sample : - Stage : - | K-means clustering analysis of the methylation events. | Methylation | - | - |
| 18798261 | 2008 | Cell line : - Source : Department of Pathology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center. Sample Type : CRC tumor and normal tissue No. of Sample : 110 serrated polyps (48 hyperplastic polyps, 32 sessile serrated adenomas and 30 serrated adenomas) and 32 tubular adenomas Stage : - | Immunohistochemistry, Microsatellite analysis and Bisulfite treatment of DNA. | Unknown | - | MLH1 and HIC1 were more frequently methylated in serrated polyps. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, C2H2-type, BTB/POZ domain containing |
| Description | This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2010] | Chromosome | 17 |
| Location | 17p13.3 |
| Start | 2055099 |
| End | 2059687 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4589 |
| OMIM ID | 603825 |
| HGNC ID | HGNC:4909 |
| Unigene ID | Hs.72956 |
| Ensembl ID | ENSG00000177374 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_006497.3 |
|---|---|
| Exon | join(1..140,1573..4589) | mRNA Sequence | Download Select all |
| Length | 3174 |
CDS Information
| Location | join(1212..1248,1573..3737) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS42229.1 |
Protein Information
| Protein ID | NP_001091672.1 |
|---|---|
| Protein Name | Hypermethylated in cancer 1 |
| Molecular Wt. (Da) | 76377 |
| Protein Sequence | Download Select all |
| Length | 733 |
| Uniprot ID | P00918 |
| Ensembl Protein ID | ENSP00000285379 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1487 | CTBP1 | 4015 | NP_001319.1 | in vivo | 12052894 |
| 3065 | HDAC1 | 3143 | NP_004955.2 | in vivo | 12052894 |
| 23411 | SIRT1 | 8381 | NP_036370.2 | in vivo | 16269335 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00651 | 37-152 | BTB |
| cl02518 | 37-152 | BTB superfamily |
| smart00225 | 48-152 | BTB |
| pfam13465 | 578-602 | zf-H2C2_2 |
| cl22375 | 578-602 | zf-H2C2_2 superfamily |
| pfam13465 | 550-574 | zf-H2C2_2 |
| cl22375 | 550-574 | zf-H2C2_2 superfamily |
| pfam00096 | 535-557 | zf-C2H2 |
| cl23491 | 535-557 | zf-C2H2 superfamily |
| smart00355 | 535-557 | ZnF_C2H2 |
| cl18194 | 535-557 | ZnF_C2H2 superfamily |
| pfam13465 | 522-546 | zf-H2C2_2 |
| cl22375 | 522-546 | zf-H2C2_2 superfamily |
| PHA03098 | 37-152 | PHA03098 |
| COG5048 | 561-609 | COG5048 |
| PHA02713 | 29-150 | PHA02713 |
| COG5048 | 501-613 | COG5048 |
| PHA03247 | 223-325 | PHA03247 |
Ontology Information
| HPRD ID | 2023 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.