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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
HK2 3099 hexokinase 2  2- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25060325   2014Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Up-regulation-High HK2 expression combined with low p-PDH expression in the invasive front lesions of CRC tumors is predictive of tumor aggressiveness and survival of CRC cases.


Gene Details



NC_000002.11 (75059782..75120481)

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Gene Type protein coding
Gene Family -
Description Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009]  
Chromosome 2
Location 2p13
Start 75059782  
End 75120481  
Strand +  
Gene Sequence

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Length 60700  
OMIM ID 601125   
HGNC ID HGNC:4923   
Unigene ID Hs.406266   
Ensembl ID ENSG00000159399   
PharmGKB ID PA29301   

mRNA Information


mRNA ID NM_000189.4
Exon join(1..1989,21639..21801,34982..35130,39646..39765, 40622..40717,41190..41289,41612..41795,44512..44667, 46034..46267,47611..47915,49057..49205,49466..49585, 52840..52935,53640..53739,53836..54019,55249..55404, 56591..56824,58143..60700)  
mRNA Sequence

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Length 7109  



CDS Information


   
Location1927..4680
CDS Sequence

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CCDS ID CCDS1956.1



Protein Information


      
Protein ID NP_000180.2
Protein Namehexokinase 2
Molecular Wt. (Da)102249
Protein Sequence

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Length 917  
Uniprot IDO00585
Ensembl Protein ID ENSP00000259607  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
5581PRKCE1500NP_005391.1in vitro;in vivo12663490   
5730PTGDS8904NP_000945.3in vitro;in vivo;yeast 2-hybrid11068878   
7709ZBTB174968NP_003434.2in vitro;in vivo;yeast 2-hybrid11068878   
29979UBQLN15440NP_038466.2yeast 2-hybrid16189514   
56893UBQLN45670NP_064516.2yeast 2-hybrid16713569   


Pathway Information


                                                                              
Pathway Name Pathway ID
Amino sugar and nucleotide sugar metabolism hsa00520
Butirosin and neomycin biosynthesis hsa00524
Carbohydrate digestion and absorption hsa04973
Carbon metabolism hsa01200
Central carbon metabolism in cancer hsa05230
Fructose and mannose metabolism hsa00051
Galactose metabolism hsa00052
Glycolysis / Gluconeogenesis hsa00010
HIF-1 signaling pathway hsa04066
Insulin signaling pathway hsa04910
Metabolic pathways hsa01100
Starch and sucrose metabolism hsa00500
Type II diabetes mellitus hsa04930


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0001281-262  NBD_sugar-kinase_HSP70_actin
cl1703781-262  NBD_sugar-kinase_HSP70_actin superfamily
cd00012529-699  NBD_sugar-kinase_HSP70_actin
cl17037529-699  NBD_sugar-kinase_HSP70_actin superfamily
pfam03727671-908  Hexokinase_2
cl08402671-908  Hexokinase_2 superfamily
pfam03727223-460  Hexokinase_2
cl08402223-460  Hexokinase_2 superfamily
pfam0034917-221  Hexokinase_1
pfam00349465-669  Hexokinase_1
PTZ0010712-460  PTZ00107
PTZ00107462-908  PTZ00107
COG502634-460  COG5026
PLN02914474-906  PLN02914
COG5026468-908  COG5026
PLN0291461-458  PLN02914
PLN02362483-906  PLN02362
PLN0240546-458  PLN02405
PLN02405483-906  PLN02405
PLN0236246-458  PLN02362
PLN0259636-458  PLN02596
PLN02596483-906  PLN02596


Ontology Information


   
HPRD ID3930
Molecular ClassEnzyme: Phosphotransferase
Molecular FunctionChemokine activity (GO:0008009)
Biological ProcessSignal transduction (GO:0007165); Regulation of cell proliferation (GO:0042127)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO