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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
HLA-A 3105 major histocompatibility complex, class I, A  6- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21947186   2012Cell line : -

Source : Department of clinical Laboratory Jiangsu, Cancer Hospital Nanjing jiangsu province, China.

Sample Type : CRC tumor and normal tissue

No. of Sample : 166 (48 CRC,38 benign)

Stage : -

real time RT-PCRDown-regulation-The expression of HLA-A mRNA in PBMC from colorectal cancer group was significantly lower than those in both benign group and healthy group.

22231555   2012Cell line : DK01, DLD1, KM12C, HCT 8 , HT 29

Source : -

Sample Type : -

No. of Sample : -

Stage : -

 Western Blotting,Immunophenotyping, ELISPOT assay,Cytotoxicity assayPolymorhpism-Human leukocyte antigen (HLA)-A*0201 is at high frequencies in Northern Asia and North America and is also the most popular type (approximately 32%) in Korea.


Gene Details



NC_000006.11 (29910247..29913661)

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Gene Type protein coding
Gene Family Histocompatibility complex, "Immunoglobulin superfamily / C1-set domain containing"
Description HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]  
Chromosome 6
Location 6p21.3
Start 29910247  
End 29913661  
Strand +  
Gene Sequence

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Length 3415  
OMIM ID 142800   
HGNC ID HGNC:4931   
Unigene ID Hs.181244   
Ensembl ID ENSG00000206503   
PharmGKB ID PA35055   

mRNA Information


mRNA ID NM_002116.7
Exon join(1..157,288..557,799..1074,1653..1928,2031..2147, 2590..2622,2765..2812,2982..3415)  
mRNA Sequence

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Length 1636  



CDS Information


   
Location 85..1182
CDS Sequence

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CCDS ID CCDS34373.1



Protein Information


      
Protein IDNP_002107.3
Protein Namemajor histocompatibility complex, class I, A
Molecular Wt. (Da)0
Protein Sequence

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Length 365  
Uniprot IDP55773
Ensembl Protein ID ENSP00000483546  



Post-translational Modification Information (Source : HPRD)


Residue Type site
NGlycosylation110
SPhosphorylation359
SPhosphorylation336
SPhosphorylation337
SPhosphorylation343
YPhosphorylation344
NGlycosylation109

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
567B2M189NP_004039.1in vitro;in vivo93   026   115   020   031   400   000   
821CANX252NP_001737.1in vivo17467700   
6957TRB@1739CAA45056.1in vitro1   043   557   814   563   320   000   000   000   000   000   000   000   
7913DEK503NP_003463.1in vitro;in vivo9684994   


Pathway Information


                                                                                    
Pathway Name Pathway ID
Allograft rejection hsa05330
Antigen processing and presentation hsa04612
Autoimmune thyroid disease hsa05320
Cell adhesion molecules (CAMs) hsa04514
Endocytosis hsa04144
Epstein-Barr virus infection hsa05169
Graft-versus-host disease hsa05332
Herpes simplex infection hsa05168
HTLV-I infection hsa05166
Natural killer cell mediated cytotoxicity hsa04650
Phagosome hsa04145
Type I diabetes mellitus hsa04940
Viral carcinogenesis hsa05203
Viral myocarditis hsa05416


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd07698207-299  IgC_MHC_I_alpha3
cl11960207-299  Ig superfamily
pfam0012925-203  MHC_I
cl0824625-203  MHC_I superfamily
pfam07654214-295  C1-set
smart00407222-293  IGc1
cd00098219-299  IgC
cd05766208-299  IgC_MHC_II_beta
cd05767224-299  IgC_MHC_II_alpha
pfam06623336-364  MHC_I_C
cl05912336-364  MHC_I_C superfamily
cd05770208-299  IgC_beta2m
cd05768223-297  IgC_CH4
cd07699223-295  IgC_L
cd05771224-296  IgC_Tapasin_R
cd05772221-307  IgC_SIRP
cd04985217-296  IgC_CH1
cd00096223-297  Ig
cd05769218-260  IgC_TCR_beta
cd05847225-290  IgC_CH2_IgE
pfam08205220-293  C2-set_2
cd07698207-299  IgC_MHC_I_alpha3
cl11960207-299  Ig superfamily
pfam0012925-203  MHC_I
cl0824625-203  MHC_I superfamily
pfam07654214-295  C1-set
smart00407222-293  IGc1
cd00098219-299  IgC
cd05766208-299  IgC_MHC_II_beta
cd05767224-299  IgC_MHC_II_alpha
pfam06623336-364  MHC_I_C
cl05912336-364  MHC_I_C superfamily
cd05770208-299  IgC_beta2m
cd05768223-297  IgC_CH4
cd07699223-295  IgC_L
cd05771224-296  IgC_Tapasin_R
cd05772221-307  IgC_SIRP
cd00096223-297  Ig
cd04985217-296  IgC_CH1
cd05769218-260  IgC_TCR_beta
cd05847225-290  IgC_CH2_IgE
pfam08205220-293  C2-set_2


Ontology Information


   
HPRD ID3976
Molecular ClassMHC complex protein
Molecular FunctionChemokine activity (GO:0008009)
Biological ProcessImmune response (GO:0006955)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO