Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HLA-DQB1 | 3119 | major histocompatibility complex, class II, DQ beta 1 | 6 | IDDM1, CELIAC1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22740942 | 2012 | Cell line : - Source : Dalian Medical University. Sample Type : CRC tumor and normal tissues No. of Sample : 100 Stage : - | PCR-SSP | Polymorhpism | - | - |
| 24338389 | 2013 | Cell line : - Source : Dalian University Hospital, Dalian, China. Sample Type : CRC tumor and normal tissues No. of Sample : 79 Stage : - | HLA-DQB1 PCR-SSP | Polymorhpism | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Histocompatibility complex, "Immunoglobulin superfamily / C1-set domain containing" |
| Description | HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] | Chromosome | 6 |
| Location | 6p21.3 |
| Start | 32627241 |
| End | 32634466 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 7226 |
| OMIM ID | 604305 |
| HGNC ID | HGNC:4944 |
| Unigene ID | Hs.409934 |
| Ensembl ID | ENSG00000179344 |
| PharmGKB ID | PA35068 |
mRNA Information
| mRNA ID | NM_002123.4 |
|---|---|
| Exon | join(1..191,1623..1892,4442..4723,5233..5343,6441..7226) | mRNA Sequence | Download Select all |
| Length | 1656 |
Protein Information
| Protein ID | NP_002114.3 |
|---|---|
| Protein Name | major histocompatibility complex, class II, DQ beta 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 261 |
| Uniprot ID | O14625 |
| Ensembl Protein ID | ENSP00000306884 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3630 | INS | 1455 | NP_000198.1 | in vitro | 11376336 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Allograft rejection | hsa05330 |
| Antigen processing and presentation | hsa04612 |
| Asthma | hsa05310 |
| Autoimmune thyroid disease | hsa05320 |
| Cell adhesion molecules (CAMs) | hsa04514 |
| Epstein-Barr virus infection | hsa05169 |
| Graft-versus-host disease | hsa05332 |
| Herpes simplex infection | hsa05168 |
| HTLV-I infection | hsa05166 |
| Inflammatory bowel disease (IBD) | hsa05321 |
| Influenza A | hsa05164 |
| Intestinal immune network for IgA production | hsa04672 |
| Leishmaniasis | hsa05140 |
| Phagosome | hsa04145 |
| Rheumatoid arthritis | hsa05323 |
| Staphylococcus aureus infection | hsa05150 |
| Systemic lupus erythematosus | hsa05322 |
| Toxoplasmosis | hsa05145 |
| Tuberculosis | hsa05152 |
| Type I diabetes mellitus | hsa04940 |
| Viral myocarditis | hsa05416 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05766 | 129-222 | IgC_MHC_II_beta |
| cl11960 | 129-222 | Ig superfamily |
| pfam00969 | 45-118 | MHC_II_beta |
| cl03042 | 45-118 | MHC_II_beta superfamily |
| smart00921 | 45-116 | MHC_II_beta |
| pfam07654 | 135-217 | C1-set |
| cd00098 | 131-221 | IgC |
| smart00407 | 144-215 | IGc1 |
| cd07698 | 127-220 | IgC_MHC_I_alpha3 |
| cd05767 | 129-220 | IgC_MHC_II_alpha |
| cd05770 | 145-221 | IgC_beta2m |
| cd07699 | 128-217 | IgC_L |
| cd05847 | 147-210 | IgC_CH2_IgE |
| cd05768 | 129-217 | IgC_CH4 |
| cd05769 | 128-189 | IgC_TCR_beta |
| cd00096 | 147-219 | Ig |
| cd05771 | 129-218 | IgC_Tapasin_R |
| cd05772 | 126-216 | IgC_SIRP |
| cd04985 | 149-219 | IgC_CH1 |
| pfam08205 | 129-216 | C2-set_2 |
| cd07697 | 128-214 | IgC_TCR_gamma |
| cd05761 | 147-214 | Ig2_Necl-1-4_like |
| pfam13927 | 128-209 | Ig_3 |
| pfam00047 | 147-207 | ig |
| cd05884 | 147-212 | Ig2_Necl-3 |
Ontology Information
| HPRD ID | 8976 |
|---|---|
| Molecular Class | MHC complex protein |
| Molecular Function | Chemokine activity (GO:0008009) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P01920 | DB00071 | Insulin, porcine | BiotechDrug |