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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HLA-E | 3133 | major histocompatibility complex, class I, E | 6 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25461612 | 2015 | Cell line : - Source : Department of Gastrointestinal Surgery, Xijing hospital. Sample Type : Tissue samples No. of Sample : 137 colorectal cancer tissues which came from patients with colorectal carcinomas at different stages Stage : TNM Stage I-IV. | Immunohistochemical staining. | Up-regulation | - | Expression of HLA-E was significantly correlated with tumor metastasis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Histocompatibility complex, "Immunoglobulin superfamily / C1-set domain containing" |
| Description | HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008] | Chromosome | 6 |
| Location | 6p21.3 |
| Start | 30457183 |
| End | 30461982 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4800 |
| OMIM ID | 143010 |
| HGNC ID | HGNC:4962 |
| Unigene ID | Hs.650174 |
| Ensembl ID | ENSG00000204592 |
| PharmGKB ID | PA35081 |
mRNA Information
| mRNA ID | NM_005516.5 |
|---|---|
| Exon | join(1..190,321..590,835..1110,1732..2007,2132..2248, 2999..3031,3136..3178,3344..4800) | mRNA Sequence | Download Select all |
| Length | 2679 |
Protein Information
| Protein ID | NP_005507.3 |
|---|---|
| Protein Name | major histocompatibility complex, class I, E |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 358 |
| Uniprot ID | P42830 |
| Ensembl Protein ID | ENSP00000296027 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 357 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 567 | B2M | 189 | NP_004039.1 | in vitro | 960 533 510 064 069 |
| 84988 | PPP1R16A | 16454 | NP_116291.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Allograft rejection | hsa05330 |
| Antigen processing and presentation | hsa04612 |
| Autoimmune thyroid disease | hsa05320 |
| Cell adhesion molecules (CAMs) | hsa04514 |
| Endocytosis | hsa04144 |
| Epstein-Barr virus infection | hsa05169 |
| Graft-versus-host disease | hsa05332 |
| Herpes simplex infection | hsa05168 |
| HTLV-I infection | hsa05166 |
| Natural killer cell mediated cytotoxicity | hsa04650 |
| Phagosome | hsa04145 |
| Type I diabetes mellitus | hsa04940 |
| Viral carcinogenesis | hsa05203 |
| Viral myocarditis | hsa05416 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07698 | 204-295 | IgC_MHC_I_alpha3 |
| cl11960 | 204-295 | Ig superfamily |
| pfam00129 | 22-200 | MHC_I |
| cl08246 | 22-200 | MHC_I superfamily |
| pfam07654 | 211-292 | C1-set |
| smart00407 | 219-290 | IGc1 |
| cd00098 | 216-296 | IgC |
| cd05766 | 205-297 | IgC_MHC_II_beta |
| cd05767 | 221-296 | IgC_MHC_II_alpha |
| cd05770 | 205-295 | IgC_beta2m |
| cd05768 | 220-294 | IgC_CH4 |
| cd05771 | 200-293 | IgC_Tapasin_R |
| cd07699 | 220-292 | IgC_L |
| cd04985 | 214-293 | IgC_CH1 |
| cd00096 | 220-294 | Ig |
| pfam08205 | 202-291 | C2-set_2 |
| cd05847 | 222-287 | IgC_CH2_IgE |
| cd05769 | 215-257 | IgC_TCR_beta |
Ontology Information
| HPRD ID | 3529 |
|---|---|
| Molecular Class | MHC complex protein |
| Molecular Function | Chemokine activity (GO:0008009) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.