Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HLA-G | 3135 | HLA-G histocompatibility antigen, class I, G | 6 | MHC-G |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24744572 | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : 39 CRC and 23 extra-neoplastic colon tissue Stage : - | - | Unknown | - | HLA-G could represent a novel prognostic immune biomarker with a prominent role in inhibiting host immune response in CRC. |
| 9855710 | 1998 | Cell line : - Source : Hospitals located in Chengdu, Sichuan, PR China, were investigated. Sample Type : CRC tumor and normal tissue No. of Sample : 201 Stage : - | RT-PCT and Immunohistochemistry | Up-regulation | - | These results suggested that HLA-G on colorectal cancer cells may be correlated with escape from immunological surveillance during colon cancer development. HLA-G expression in 39 human colorectal cancers and 23 extra-neoplastic colon tissue samples were studied by RT-PCR. |
| 17277760 | 2007 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry | Up-regulation | - | HLA-G might serve as an independent prognostic factor for colorectal cancer patients. HLA-G protein expression was observed in 64.6% (130/201) of the primary site colorectal carcinomas, but not in the normal colorectal tissues or benign adenomas. HLA-G expression in the tumors was significantly correlated with the depth of invasion, histological grade, host immune response, lymph nodal metastasis and clinical stages of the disease. |
| 20473865 | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | ELISA, Receiver operating characteristic (ROC) curve | Up-regulation | - | sHLA-G may be a useful indicator in differentiating colorectal cancer from benign colorectal diseases. Serum sHLA-G levels were determined using ELISA. sHLA-G concentrations were significantly higher in colorectal cancer compared to normal colorectum, hyperplastic polyp, inflammatory bowel disease and adenoma. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Histocompatibility complex,Immunoglobulin superfamily / C1-set domain containing |
| Description | HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] | Chromosome | 6 |
| Location | 6p21.3 |
| Start | 29826979 |
| End | 29831122 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4144 |
| OMIM ID | 142871 |
| HGNC ID | HGNC:4964 |
| Unigene ID | Hs.512152 |
| Ensembl ID | ENSG00000204632 |
| PharmGKB ID | PA35083 |
mRNA Information
| mRNA ID | NM_002127.5 |
|---|---|
| Exon | join(1..66,755..939,1069..1338,1565..1840,2440..2715, 2838..2954,3400..3432,3790..4144) | mRNA Sequence | Download Select all |
| Length | 1578 |
CDS Information
| Location | join(867..939,1069..1338,1565..1840,2440..2715,2838..2954, 3400..3404) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS4668.1 |
Protein Information
| Protein ID | NP_002118.1 |
|---|---|
| Protein Name | HLA-G histocompatibility antigen, class I, G |
| Molecular Wt. (Da) | 35607 |
| Protein Sequence | Download Select all |
| Length | 338 |
| Uniprot ID | O75493 |
| Ensembl Protein ID | ENSP00000084798 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 110 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 567 | B2M | 189 | NP_004039.1 | in vivo | 9228302 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Allograft rejection | hsa05330 |
| Antigen processing and presentation | hsa04612 |
| Autoimmune thyroid disease | hsa05320 |
| Cell adhesion molecules (CAMs) | hsa04514 |
| Endocytosis | hsa04144 |
| Epstein-Barr virus infection | hsa05169 |
| Graft-versus-host disease | hsa05332 |
| Herpes simplex infection | hsa05168 |
| HTLV-I infection | hsa05166 |
| Natural killer cell mediated cytotoxicity | hsa04650 |
| Phagosome | hsa04145 |
| Type I diabetes mellitus | hsa04940 |
| Viral carcinogenesis | hsa05203 |
| Viral myocarditis | hsa05416 |
Structure Information
| PDB ID | 1YDP |
|---|---|
| Resolution | 1.9 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | MHC class I antigen |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07698 | 207-298 | IgC_MHC_I_alpha3 |
| cl11960 | 207-298 | Ig superfamily |
| pfam00129 | 25-203 | MHC_I |
| cl08246 | 25-203 | MHC_I superfamily |
| pfam07654 | 208-294 | C1-set |
| smart00407 | 222-293 | IGc1 |
| cd00098 | 222-299 | IgC |
| cd05766 | 208-299 | IgC_MHC_II_beta |
| cd05767 | 208-299 | IgC_MHC_II_alpha |
| cd05770 | 208-298 | IgC_beta2m |
| cd05768 | 223-291 | IgC_CH4 |
| cd07699 | 223-293 | IgC_L |
| cd05771 | 224-296 | IgC_Tapasin_R |
| cd00096 | 223-291 | Ig |
Ontology Information
| HPRD ID | 5225 |
|---|---|
| Molecular Class | MHC complex protein |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.