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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
HLTF 6596 helicase-like transcription factor  3HIP116A, HLTF1, RNF80 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22362391   2012Cell line : -

Source : -

Sample Type : Serum samples

No. of Sample : 311 CRC and normal tissues 54

Stage : TNM Stage I-IV

Methylation-specific quantitative PCR,immunoenzymometric assayMethylation-Methylation of HLTF and HPP1 DNA in serum significantly correlated with tumor size, stage, grade and metastatic disease.

24708595   2014Cell line : -

Source : -

Sample Type : Serum samples

No. of Sample : 259

Stage : TNM Stage I-IV.

Methylation-specific RT- PCRMethylation-Methylation of HLTF and especially HPP1 detected in serum is strongly correlated with cell death in CRC using LDH as surrogate marker.


Gene Details



NC_000003.11 (148747904..148804341, complement)

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Gene Type protein coding
Gene Family RING-type (C3HC4) zinc fingers
Description This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq, Jul 2008]  
Chromosome 3
Location 3q25.1-q26
Start 148747904  
End 148804341  
Strand -  
Gene Sequence

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Length 56438  
OMIM ID 603257   
HGNC ID HGNC:11099   
Unigene ID Hs.3068   
Ensembl ID ENSG00000071794   
PharmGKB ID PA35949   

mRNA Information


mRNA ID ?NM_003071.3
Exon join(1..238,1666..1873,10508..10674,12207..12340, 13233..13330,14898..14972,15112..15303,18220..18315, 21689..21764,23031..23124,25697..25776,25868..25912, 26751..26837,31155..31252,36180..36323,37554..37692, 38392..38527,40296..40475,44265..44389,44887..45065, 46399..46524,46862..46974,47326..47506,51557..51637, 54183..56438)  
mRNA Sequence

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Length 5358  



CDS Information


   
Location219..3245
CDS Sequence

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CCDS ID CCDS33875.1



Protein Information


      
Protein IDNP_003062.2
Protein Namehelicase-like transcription factor
Molecular Wt. (Da)184515
Protein Sequence

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Length 1009  
Uniprot IDQ96GD4
Ensembl Protein ID ENSP00000313950  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation398
SPhosphorylation398
SPhosphorylation400;-
SPhosphorylation397;-
SPhosphorylation400;-
SPhosphorylation397;-
TPhosphorylation390
YPhosphorylation394
TPhosphorylation390
YPhosphorylation394
TPhosphorylation736
TPhosphorylation736
SPhosphorylation373
SPhosphorylation378
SPhosphorylation373
SPhosphorylation378
TPhosphorylation469
TPhosphorylation469
TPhosphorylation641
TPhosphorylation645
TPhosphorylation641
TPhosphorylation645
TPhosphorylation50
TPhosphorylation50

Enzyme Information


No matching records could be found.

PPi Information


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No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00079829-957  HELICc
cl21455829-957  P-loop_NTPase superfamily
cd00162759-804  RING
cl17238759-804  RING superfamily
cd00046478-588  DEXDc
cl21455478-588  P-loop_NTPase superfamily
cd00046288-320  DEXDc
cl21455288-320  P-loop_NTPase superfamily
pfam0879760-154  HIRAN
cl0741860-154  HIRAN superfamily
smart0091065-144  HIRAN
pfam00271871-950  Helicase_C
smart00490871-950  HELICc
smart00184760-800  RING
pfam13639758-801  zf-RING_2
pfam13923760-800  zf-C3HC4_2
pfam00097760-800  zf-C3HC4
pfam13920756-806  zf-C3HC4_3
pfam14634759-801  zf-RING_5
pfam15227760-800  zf-C3HC4_4
pfam13445760-798  zf-RING_UBOX
pfam00176473-722  SNF2_N
COG0553472-1009  HepA
PLN03142479-982  PLN03142
smart00487472-601  DEXDc
COG5574623-811  PEX10
PLN03208751-810  PLN03208
TIGR00599760-809  rad18
COG5432760-809  RAD18
PHA02929742-802  PHA02929
smart00487238-320  DEXDc
COG1061465-701  SSL2
pfam12678756-801  zf-rbx1
COG5540759-804  COG5540


Ontology Information


   
HPRD ID4998
Molecular ClassDNA binding protein
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO