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General Information

• Evidence
• Gene
• mRNA
• CDS
• Protein
• PTM
• Enzyme
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• Pathway
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Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
23201162	2012	Cell line : - Source : - Sample Type : CRC tumor and control tissue No. of Sample : 50 Stage : -	RT-PCR, Immunoblot analysis, Luciferase reporter assays and Chromatin immunoprecipitation	Down-regulation	-	In CRC cells, miR-137 targets FMNL2 messenger RNA and is regulated by the transcription factor HMGA1. Levels of miR-137 and HMGA1 are reduced, and levels of FMNL2 are increased, in CRC samples compared with adjacent normal mucosa.
20473941	2011	Cell line : SW 480, HT 29, SW 837, SW 48, T 84, LS 513, HCT 116, SW 1463, SW 1116, LS 411N, NCI-H716, LoVo, NCI H508, COLO 201, COLO 320DM, LS 123, LS 174T, DLD-1, Caco 2, LS 1034, SK-CO-1, RKO, SW403, SW620. p53HCT 116 Source : ATCC Sample Type : - No. of Sample : - Stage : -	Cell Viability Assay, Microarray, Estimation of Signal Flow Networks and Pathway analysis.	Up-regulation	-	-
22276142	2012	Cell line : HCT116, SW480 Source : - Sample Type : Mouse model No. of Sample : - Stage : -	real time RT-PCR, Western blotting, Anchorage-independent cell growth in soft agar, migration.	Up-regulation	-	HMGA1 is a key regulator, both in metastatic progression and in the maintenance of a stem-like state. HMGA1 or downstream pathways could be rational therapeutic targets in metastatic, poorly differentiated colon cancer. HMGA1 induces expression of Twist1, a gene involved in embryogenesis, EMT, and tumor progression, while HMGA1 represses E-cadherin, a gene that is down-regulated during EMT and metastatic progression. HMGA1 is among the most enriched genes in colon cancer compared to normal mucosa.
22706202	2012	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	-	Up-regulation	-	Elevated CAV1 upregulates glucose uptake and ATP production through HMGA1-mediated GLUT3 transcription.
22968445	2012	Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : - No. of Sample : - Stage : -	Laser capturemicrodissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation.	Up-regulation	9.4	-
23835740	2013	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	Microarray	Up-regulation	-	High mobility group A1 (HMGA1) was identified as a biomarker for poor prognosis and metastasis formation. HMGA1 expression as a predictive indicator of lymph node metastasis in CRC cases. Sample size: 249 cases.

Gene Details

Chromosome: 6; NC_000006.11 (34204577..34214008)
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Gene Type	protein coding
Gene Family	High-mobility group / Canonical
Description	This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	6
Location	6p21
Start	34236800
End	34246231
Strand	+
Gene Sequence	>gi|568815592:34236800-34246231 Homo sapiens chromosome 6, GRCh38.p2 Primary Assembly CATTTGCATGGCCCCGCCCCCTGAGTGACACGGCTGGCGCGGGCGGGCCCGTCCCCCCTGCCCCTGGGTC GCTCTTTTTAAGCTCCCCTGAGCCGGTGCTGCGCTCCTCTAATTGGGACTCCGAGCCGGGGCTATTTCTG GCGCTGGCGCGGCTCCAAGAAGGCGTGAGTTCGCGGCCGCTCCGGTGGCTTCTTTTTTTTATATCTATAA TTTAATTAAATTATTTATTTATTGAGGCCGCGCACGGGCCGTGCCCAGCTTCCTGCCCCTCGCCATCCTT CGGGGGAGGGGGAATATTTTTGTCCCCCCGCCTGGCTGTGACACATAAATACCCCGCGGGGGCCTGGGCG GCGAGCACGCGGCGGCGGCGGTCTCTGAGCGCCTCTGCTCTCTCCCGGTTTCAGATCCGCATTTGCTACC AGCGGCGGCCGCGGCGGAGCCAGGCCGGTCCTCAGCGCCCAGCACCGCCGCTCCCGGCAACCCGGAGCGC GCACCGCAGGCCGGCGGCCGAGCTCGCGGTGAGTCGTCCCCGGGGCCCGCGGCGGCGGCGGCGGAGGGGG GCGCCCGCGCCCCCGCCCGCACGTCGCCCCTCCTGCGAGCCGCCCGGGGCTGCAGCGCGCGCCGCCGGCT TTATTCCCAGGCCGGGGCGGCGCGAGCCGGCGGCGGGGGAGGGCCGCGCGGCGCGGGGGCGGGCGGCGGG GCCCGGCGGCGCGGGGAGGACGCCCGCACCCCTTCCCCCGCGCCGCGGGCGCCCTGCGGGGGGCGGGGAC CCGGGAAAGGCGCGCGGTGGGGGAGGGGGCGCGCAGCTGCGGCGAGCGCGAGTTGTGCACCCGGCGGAGC CCGGAGGAGCCCGGCGCACCTCGCGCGGCGGCCGCTCCCGCTGGAGCCGGAGCCCGAGCCCGAGCCCGGG CCCGGGTGAGGGGCGGGGAGAGACACGGGCTGCGGCGCGGCAGGAGAGTGGGGGGTCGGGCGCCCCCCGC AGCTCAGGGAAGTTCTGGAAGTGAGGGAGATGGGGAGGAACCCCCAAATTCGGCCCTACGCCCTCTCGGC CTTTCTCTCGCGCCCCCTCCGCAGATGAGGCCGGAGCGCGGGCCTGGGTTTGGGGCTTCACCCCGACCCC ACCTCTGGCCTGGCCCGCGCCTCTTCAGCCCCAGGGGCCGGGCCTGCCCTCCGCCCCCACAAACTGGTTT CGCTGCTTTGCTGGGCTCTGTTGGAACTAGTCCCTTTGACTCCCCGTTTCTATTTTATTTTCTTCTGGGG CTTTATTTTGCGGGGAGGGGACGGAGGGAGGGGGCTTTCTTCCTCTCCCCCGCGCCCGCGCGCGCCAGGT TTCCTGCCCCAAGGCGGGCTTGGGTGCCCCCTCTGGCAGGAAGTGGGGCCGGGTGCACCCGCGTGGCGGT GCATGCGGTCGGGGTGCGCTGCTTTCCCGCGCCTGCAGGAGCGGCCTGCGCCCCTCCCCCCGCGCGCCCT GGCCCCGGGTCCCGCCGGCCGGCCTGCAACGGCCGGGCGCAGACACTTGCAGAGTCACCCTCGGGCCGGG TCTGGAGCCTGATGCCTCGGGGGTTTAGCCCTAGCCGCTAGGCGGGTAGGCAAAGTGTCGGGTTGAAAGG GTCTCCGGGAACCTACTTCTTCCTGCTCGCCAACTTGCTGTGTGACCTTAGGCAACTCAAGGCTTCTCTG GGCTACTTTTTTACGGGGGACGGGGAAGAAAACAAGGGAACCCCCAAGATAATTTCCTAGGGCCTTTCCT GCAGAGTCCTTAAGTATTTGAGGAGCACAGTTTGCATGCACAGTGTATGGAGGAGACAGGCTTGAGGCCC AAGCGGGCTTATTACAAAGTGAGGGATTGGGGTTAGGCCCTAAATGTAGTTCCTCCAAGACAGGCCTCTG ATGTTCAGAAACAGGTGGAAAAGACGAACGTTTCTTGGCCTCACTGGAAAGGGCCTCGGGCCTTCATTTA GTTCGTGGGGGGTTGGCTGAGGGGATTAAAGGGTCCCCAGCAGCAAGAGGTGGGGGGAGGCACCAGATGG TATGAGAGCTTCCAGGGAGACCCGCCAAGATCTCCAGGCAGGCCGGGCCAGGCTCTCTGGGATTCCGGAC TGGCTTCGCCCAACTGGAACCCCCTCGATGAGGGGGCCCCAGGCAGACCTTATATGAGGTCAGCACTCGT TTAGTTGATTAATTTTGATGTTTAGTTTGAAGGGGGACCTGTGGTGTAATATAAGATTCTAATCACTGCC TGTAATTGCAGAGCAGGCCAAGCCACTAATGACGGAGCAGGATAAATCACCAACCACCTTGTTTAAAAGG GTCTCCAAGTCTGAAACATTATAAGATAGAATAATTACCAAAGTCCTGCTGTCTGGAGGGTCTCTTGATG CTTGAAAATGGAGGTCCTGGGCCCTCTAGAAATCACAAGTTTGCAAAAATGTTTTTTTCCTCTCATTGGG GTAAAAACTCTTTTTCTTCTTTTTTTTTTTTCTTTTAAATTAGACATGGGAGTCCCACCGTATTGTCCAG GCTGGTCTCGAACTCCTGACCTCAAGCAGTCCTCCTGCTTTGGCATCCCAAAGTGCTGGGATTACAGGCA TGAGTCACCTCACCTGGCCCATAAATCATTTTCAAATGGTCTAGTTCTTATTTTGGTTAGAGTGAAGATT TCTTTCTATTATTTTAAGTTTTTCTAAACTATTACCTAGTTTGATCCTTGAAGCAGTCAGGAGGTAGTTC AGGCAGGTACCTTATAATTACCTTGATCTTACAGATTGAGAGGGGTTCAGAAGTGGAGCCGCTTGTCCCA CCCCTTACCATGGCAGGCAGGGATTGGTTACTGGAAAAATGTGTAGCCTAGGCCTCCGGCGTCTCATCCA TCTGTAGCCTGGGGATAAGGACTAGGATGAAGATGTGGAGGACTGTCCTTTTTAAGCCTGTAATACAGGG TATTCCCAAATACAGGTTGCAGGCCCTCCTTCCAATGAGAAGTTTTAGGAAAACTCAAAATTGATGGGGT TAATTAAACCCCAACAGGCCTCTAAGAAGAAGGAAGATGCTAGAAAATGACCAAGAAGGTTTTAGGATGA GCCCTAAACCTCATCCTAAAGGATGAGGGCCAGCCAGGGTCTGTTAGGCGGTGCATTTCAGTTGGAGAAT TCCCTACCCATCTGACAAAGTCCCATCTGACTCCAGTTGGGCAGAGGAGGGGTAAGGGGAAAGAGGAGGG TGGCCTTTGGCTTTGGGCTCACTTTCCTCCCCCACCTCACCCACTAGCTTCAACCATCTCCTCCCTCCCT CAATTATACCAATCTGAATTCTCCAGGGATTTACCCTGGGTGAGAACAGAGAAGAGAGCTGGTGGTGGGC ACCACCCCTGGCTGTGTGATTGGCTCTTTTTGGTCCTGAGTCTTGCACCTTGCCAGATAGGCAATATTGT CAGTGAGGTGGGCAGGGGATCAATGTCCATAGCTGCCAGATCGCAAGGTCTCATTCTTTCCATTTTCCCA CTGAACTGCGTAGGCTGGATTTTCTCTTAAAGAGAAAGGGCAGCAGTTGACTACAGAAGGAGGGGATGCT GGCAATACGTCAGATCTCACCTCCCCACACCTTTGTCCCAGGGTGGCCTCACCCATGTAGCTAGGTCTGG GCTGGCTGTACCTCCTGGGACCCCCCCCACCACGCTGCACTGGGGCGGTGTTAAGGCAGGACAACAAAGA GCCCTTCTGAACAGGAGATAGATAAGAAGCTGATTAGGGCCAACGGCCCTTCCCCGCCCTTGGCAGCATC TGGGGGTGGGCAGACCCCTCCATCCTGGGCAGAGTAGGAGGCCTGGGGGCCCATGGGAGCACAGTTTTCT GCAGTGTGCCTTGAAGGTGTGGGTGATGAGGGGGTAGAAAGTGGCTGAAGCGAGATGTTTGTCTAAAAGC ACTTTTCTGTCTCCCAGCATCCCAGCCATCACTCTTCCACCTGCTCCTTAGAGAAGGGAAGATGAGTGAG TCGAGCTCGAAGTCCAGCCAGCCCTTGGCCTCCAAGCAGGAAAAGGACGGCACTGAGAAGCGGGGCCGGG GCAGGCCGCGCAAGCAGCCTCCGGTGAGTCCCGGGACAGCGCTGGTAGGGAGTCAGGTGGGTGTCCAAAC CTTTGCTTCACTTGGTTTACCCTTTGGGGCTAGGGAGGTGCCTGGAGTTTCATTCAGCAGGCGAGACCAT GCATGGAGGGTGCAGAATGATTCTGCGCAGTAAGCGTGTGGGTGTGTCCTCCCACCTGTGTGTACTCCTG CCCCACTTGCAACCCTGGTCAGATCTCTATAGAGACCCCAGGAGAGAACCGGGGGCCGAGGAATTCAAGA TAAATTCTGAAGCCAATGGCAAACAGTCCAAACCTAAAGCACCCCAGAGGTCACATGGCCAGTGCTTAAA ACACTCGCCTTTTTCTTAATTTCCAATCCACTGTGGACCAGTAATTTTAAAATGCAGTAAAGACGAATGA ACAAAAATGAACATAGAAGCCCAGGGTTTTTAATCATTAGATTCAGTGCACGTAAAATGATTTTTGTCAA TTTGCTGTAAAGTTGCTGAATACTTATGGTCGATTCTTGTACTTCCTCATCCCAGGTGAGAAACGGGTGC CTGCGTGGGCCAGCACCTGTTTGTGCACAGGCCAGTTATGAGTAGTTCTGGAATGGGCATTGCCCCTGGC TCTTTAGATGGAAATTGAAGCCCAAGAAGTCAAAAATGTTGGGGAGTTGGTGGCAGTGACCCTCAGAACC CTGGTGCTGCTCTCCCCACAAAGTCCTCATAGAAGGATGAGGCTGCCAGCCTGGCGCTGTGGGGCACCCT AGGGAGCATGGCCATTTGGGCATGGGGGGGACCCCATATTGGCCTCTTACAGAGGCAGCTGTCACCCAAG TGAAGGGTGGCTGTTGGTGAAGCCCAGTTACTTCCCTTCCCTGGGAGAGAGGTAAGAGGAGTTGAGTTCG ACCTCTGCCCCTTAAACATGATACAGGTTGTTCACCTGCAGGTTTTCCCTGTCCGTACGGTGGAGAGTGG TCTGTGCTGACCTGGGCCCAGGGAGACACGAGCTGTGAGGAGTCTGCTGTGTTGGAATTCAGAGCCTGGG GTGGGGTCATTTGTCCTCTTAGCCTAGCTCCCTCAGCCTCCCCTCCTACCCCACCTGTTAGCCATGGTCA GTGGGAGGTGTCAGGAGGGGTGCAGGGTTACTGGACCCTGGTTATAGACAGACCATGGGCGGCCCCCTAG GAAACAGTAGCTGGCGCGCCTTCACCACACACCTTATATGCATTATGCAGCAGCTTTTTATTCTATCTAC GGCTTATTAAAATTTCAGTGGGAATGATGGCAGGGATCTCTGGAGTCCGGCTATAATTCCCCTTCTCTGG GGGCAGCCTGGATGGGCTCCAGGTTTGCAAGTGCAGGCAGGGAGTGTGTGTCCAGCATAGGTCATCTGAG AGGGTGGGCAGTGATCATGGCCCAGTGCTAGATAACCATACATTACCCATTTAATCTCCATGACACCCTG CAAGGGAAGTCTTCACCATTTATAGATGAGGAAACTGAGGCTCCAGCATTAAGTGTCCCACCCAAGATAA GTGTCAGAACTGAGACTTGGGCAGAGCCACCTAACTGTCTTTCTGTCCCCAGAATGCCTTTCCTAGGGGT CTTCTGGGCTCTTGTCATTTTGCATCTTAGAAACCTGCAGGGAAGCAAGGGGAGAGGTGGGAGGCACTTT GCAAAGATGCTCAAACTGGAGCTTTGGATCCTGAAGGGATTCCTAGGTCAGGGATGGTTTGTGGTTCTTG GTTCTTGCTGACTTAACCTTGTTGAGGAGGCAGAGGGCTGTGTCTTCTGAGGGGGTGGAAACAGGTGATG ACTGTCCCTGACTACCCCCTCTGTCTTTACAGAAGGAGCCCAGCGAAGTGCCAACACCTAAGAGACCTCG GGGCCGACCAAAGGGAAGCAAAAACAAGGGTGCTGCCAAGACCCGGGTGAGACTTGAGATGGGACTACCC CTGGGTGGATGACTAGCAGAGGATCCTCTTGTTGGCACCATGGCCACGGCTGTGGGGAGGTCTGGGAAGG GGCTCAGTCATCTCAGTTGTGTACCCCCTTCCCTGGTACAGGGATGGCAGTGAGTCTTTGCTAACTGGGG AGAGTGGGGCGATGACTAAGGTCTTACTTCTGGGGGGTTGGTCCTGCCCAGGACACTGCGGAGATCAGGT CAGAAGTCCCACAGCTTTCCTGATCTAGAGAAGGGCAGAGTGGGGAGAATGGAGGGTCCCTGCCAGTCCC TGGGCTGAGAATGTTACCTTCTCTTGGGGTTCCCTGGAGCCTGAAGGGGTGGGGACAGGCAGCAAAGGCC AGATTCACAGTGACATTAGCCTTTCAGAAAAGTTGTTTTGTTTTTTATTTTATTTTTTCTAAGACACGAC TCATATCCTCTGAGTCATGGGCGGAGGTGGGAGTAGGGGGCGTGTGTGTATGTCGAGGGGGCAAATGTGG CTGGCCAGTCATTGCCAGCTGGACTTGGGTGGGCCTGTTGGGTGAGAGTGTTGGGTCACCCTGAACAGGC AGGTAGGTCTGCCCCCCATCACTATTGGGCATCGGGTGAGCACTGATGAGCATTTTGGACTTAGGAGATA TTTTCTCTAACCCTCTAGAAAACCACCACAACTCCAGGAAGGAAACCAAGGGGCAGACCCAAAAAACTGG TAGGTGAAGAAGCAGACTGCTGCTTGCCTCCTGGGCTCTTTTGAGTTGAGGGTGTTGAGTACACAGTACC TGATGCTATGCACCCCCTATGGAAAGGCTCTCCTTGACCTGCTGGGACATCAGATTTTACAGAAGTCCAG AGAGGGGAAGGTACCTGGCCTGGGCTGTGCCCATGAGAAGTGAGGGGTCCCAGGTATAAATCAGACCACA TCCCCCTGCCCTGCCCTGCCCTAGTTGTGTGTGGGGGTCCCTCCCTCTCCTGCTCCTAGAATACTCAGAA CTTCTAGGGGAGATCTTGGAAGTCATCTAGCCTGTGTCCCCCTCAATTAGAGATGAGGAAAGGAAGCCAT AGGGGGAAGGTTTGTCCTTCCTATGAGCCTCTGCAGAAGAGAAACAGCGAAGGAGCTGGGCCCTGGGAGG GGTCGGTGCTGGAGTTCTGATGTGACCCACCACACTGCACTGGAGGGCACCATCCAATTCTGGGTCCCCA AACAGCTGGTGGAAAGGCTCGGTGGGCTGAGTCAAGAAGCTGCCTCTAGGGGGCCACTGCAGTTAGGGTC ACCCCAGCCTTCCAGCTCCTGGCCCTCTCCTACCCCCAGCCTGCCCCCTCAAATCCCTGAAGCTGTCATT CCTTGAGCTGAGCCACTGCTGGGGTGGGGGGGTTAGGGGGTGCTGCTGGCCAGGCCCCAAGAGTGAGTAA CAGGAAACAAGTTGTTTTGGAGTTTGTGCCTGGCACGGGGGCTGTAGCCCCGTGTGGTGTCCCGACATTC CCGCCCAGTGAGTGAGCCCCGGCGGCACACACTTCCCCTTCCTCCCCACCCCGGCCTAGGGTCAGCCCTC GGCCACCCCGGAGGGCCAGGGCACCACAGCACAGCATCTGCCCCTGTGGGCCAAGGACCTGGTTCCCCTG CACCCACCAGCGGGCTCTTGCACCTTCCAGCCACCCCTTCCCATTTCCTCCCCCAGCCACCTCTTCCCCC ACCTCCTCTTCTCCCCTAGGGAGTCAGTCACATCCTGAAGCTCATTGCTGCCCTGAGCTCTGCCCTCCTG CCCTCCCTGGGCCTGGGGGCCAAGGGGGCTTGGCTCCTGGCTCTGGGTGAGAGCAGCATGTGTGTGGGGT TTTTTCCTCCTTTTAAATTCTTTTTATGAATGAAGCCGGGCCGTGGAGGTTGCTGAGTCACCCACACACT CAGCCCTGACTCATCCCTCTTCAGGAGAGCCAGGGAGTGCAGGGAGCGGGTGGGGCCAGCCTCTGGGGGT GGAAGAGGGGGACCGGGCCAGAGCTCACACCAACAACTGCCCACCTCACAGGAGAAGGAGGAAGAGGAGG GCATCTCGCAGGAGTCCTCGGAGGAGGAGCAGTGACCCATGCGTGCCGCCTGCTCCTCACTGGAGGAGCA GCTTCCTTCTGGGACTGGACAGCTTTGCTCCGCTCCCACCGCCCCCACCCCTTCCCCAGGCCCACCATCA CCACCGCCTCTGGCCGCCACCCCCATCTTCCACCTGTGCCCTCACCACCACACTACACAGCACACCAGCC GCTGCAGGGCTCCCATGGGCTGAGTGGGGAGCAGTTTTCCCCTGGCCTCAGTTCCCAGCTCCCCCCGCCC ACCCACGCATACACACATGCCCTCCTGGACAAGGCTAACATCCCACTTAGCCGCACCCTGCACCTGCTGC GTCCCCACTCCCTTGGTGGTGGGGACATTGCTCTCTGGGCTTTTGGTTTGGGGGCGCCCTCTCTGCTCCT TCACTGTTCCCTCTGGCTTCCCATAGTGGGGCCTGGGAGGGTTCCCCTGGCCTTAAAAGGGGCCCAAGCC CCATCTCATCCTGGCACGCCCTACTCCACTGCCCTGGCAGCAGCAGGTGTGGCCAATGGAGGGGGGTGCT GGCCCCCAGGATTCCCCCAGCCAAACTGTCTTTGTCACCACGTGGGGCTCACTTTTCATCCTTCCCCAAC TTCCCTAGTCCCCGTACTAGGTTGGACAGCCCCCTTCGGTTACAGGAAGGCAGGAGGGGTGAGTCCCCTA CTCCCTCTTCACTGTGGCCACAGCCCCCTTGCCCTCCGCCTGGGATCTGAGTACATATTGTGGTGATGGA GATGCAGTCACTTATTGTCCAGGTGAGGCCCAAGAGCCCTGTGGCCGCCACCTGAGGTGGGCTGGGGCTG CTCCCCTAACCCTACTTTGCTTCCGCCACTCAGCCATTTCCCCCTCCTCAGATGGGGCACCAATAACAAG GAGCTCACCCTGCCCGCTCCCAACCCCCCTCCTGCTCCTCCCTGCCCCCCAAGGTTCTGGTTCCATTTTT CCTCTGTTCACAAACTACCTCTGGACAGTTGTGTTGTTTTTTGTTCAATGTTCCATTCTTCGACATCCGT CATTGCTGCTGCTACCAGCGCCAAATGTTCATCCTCATTGCCTCCTGTTCTGCCCACGATCCCCTCCCCC AAGATACTCTTTGTGGGGAAGAGGGGCTGGGGCATGGCAGGCTGGGTGACCGACTACCCCAGTCCCAGGG AAGGTGGGGCCCTGCCCCTAGGATGCTGCAGCAGAGTGAGCAAGGGGGCCCAAATCGACCATAAAGGGTG TAGGGGCCACCTCCTCCCCCTGTTCTGTTGGGGAGGGGTAGCCATGATTTGTCCCAGCCTGGGGCTCCCT CTCTGGTTTCCTATTTGCAGTTACTTGAATAAAAAAAATATCCTTTTCTGGA    Download   Select all
Length	9432
OMIM ID	600701
HGNC ID	HGNC:5010
Unigene ID	Hs.518805
Ensembl ID	ENSG00000137309
PharmGKB ID	-

mRNA Information

mRNA ID	NM_145899.2
Exon	join(1..164,405..518,3938..4116,5913..5996,6669..6719, 8032..9432)
mRNA Sequence	>3159 CATTTGCATGGCCCCGCCCCCTGAGTGACACGGCTGGCGCGGGCGGGCCCGTCCCCCCTGCCCC TGGGTCGCTCTTTTTAAGCTCCCCTGAGCCGGTGCTGCGCTCCTCTAATTGGGACTCCGAGCCG GGGCTATTTCTGGCGCTGGCGCGGCTCCAAGAAGGCATCCGCATTTGCTACCAGCGGCGGCCGC GGCGGAGCCAGGCCGGTCCTCAGCGCCCAGCACCGCCGCTCCCGGCAACCCGGAGCGCGCACCG CAGGCCGGCGGCCGAGCTCGCGCATCCCAGCCATCACTCTTCCACCTGCTCCTTAGAGAAGGGA AGATGAGTGAGTCGAGCTCGAAGTCCAGCCAGCCCTTGGCCTCCAAGCAGGAAAAGGACGGCAC TGAGAAGCGGGGCCGGGGCAGGCCGCGCAAGCAGCCTCCGGTGAGTCCCGGGACAGCGCTGGTA GGGAGTCAGAAGGAGCCCAGCGAAGTGCCAACACCTAAGAGACCTCGGGGCCGACCAAAGGGAA GCAAAAACAAGGGTGCTGCCAAGACCCGGAAAACCACCACAACTCCAGGAAGGAAACCAAGGGG CAGACCCAAAAAACTGGAGAAGGAGGAAGAGGAGGGCATCTCGCAGGAGTCCTCGGAGGAGGAG CAGTGACCCATGCGTGCCGCCTGCTCCTCACTGGAGGAGCAGCTTCCTTCTGGGACTGGACAGC TTTGCTCCGCTCCCACCGCCCCCACCCCTTCCCCAGGCCCACCATCACCACCGCCTCTGGCCGC CACCCCCATCTTCCACCTGTGCCCTCACCACCACACTACACAGCACACCAGCCGCTGCAGGGCT CCCATGGGCTGAGTGGGGAGCAGTTTTCCCCTGGCCTCAGTTCCCAGCTCCCCCCGCCCACCCA CGCATACACACATGCCCTCCTGGACAAGGCTAACATCCCACTTAGCCGCACCCTGCACCTGCTG CGTCCCCACTCCCTTGGTGGTGGGGACATTGCTCTCTGGGCTTTTGGTTTGGGGGCGCCCTCTC TGCTCCTTCACTGTTCCCTCTGGCTTCCCATAGTGGGGCCTGGGAGGGTTCCCCTGGCCTTAAA AGGGGCCCAAGCCCCATCTCATCCTGGCACGCCCTACTCCACTGCCCTGGCAGCAGCAGGTGTG GCCAATGGAGGGGGGTGCTGGCCCCCAGGATTCCCCCAGCCAAACTGTCTTTGTCACCACGTGG GGCTCACTTTTCATCCTTCCCCAACTTCCCTAGTCCCCGTACTAGGTTGGACAGCCCCCTTCGG TTACAGGAAGGCAGGAGGGGTGAGTCCCCTACTCCCTCTTCACTGTGGCCACAGCCCCCTTGCC CTCCGCCTGGGATCTGAGTACATATTGTGGTGATGGAGATGCAGTCACTTATTGTCCAGGTGAG GCCCAAGAGCCCTGTGGCCGCCACCTGAGGTGGGCTGGGGCTGCTCCCCTAACCCTACTTTGCT TCCGCCACTCAGCCATTTCCCCCTCCTCAGATGGGGCACCAATAACAAGGAGCTCACCCTGCCC GCTCCCAACCCCCCTCCTGCTCCTCCCTGCCCCCCAAGGTTCTGGTTCCATTTTTCCTCTGTTC ACAAACTACCTCTGGACAGTTGTGTTGTTTTTTGTTCAATGTTCCATTCTTCGACATCCGTCAT TGCTGCTGCTACCAGCGCCAAATGTTCATCCTCATTGCCTCCTGTTCTGCCCACGATCCCCTCC CCCAAGATACTCTTTGTGGGGAAGAGGGGCTGGGGCATGGCAGGCTGGGTGACCGACTACCCCA GTCCCAGGGAAGGTGGGGCCCTGCCCCTAGGATGCTGCAGCAGAGTGAGCAAGGGGGCCCAAAT CGACCATAAAGGGTGTAGGGGCCACCTCCTCCCCCTGTTCTGTTGGGGAGGGGTAGCCATGATT TGTCCCAGCCTGGGGCTCCCTCTCTGGTTTCCTATTTGCAGTTACTTGAATAAAAAAAATATCC TTTTCTGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA    Download   Select all
Length	2031

CDS Information

   

Location	join(3982..4116,5913..5996,6669..6719,8032..8085)
CDS Sequence	>gi|208431749:323-646 Homo sapiens high mobility group AT-hook 1 (HMGA1), transcript variant 1, mRNA ATGAGTGAGTCGAGCTCGAAGTCCAGCCAGCCCTTGGCCTCCAAGCAGGAAAAGGACGGCACTGAGAAGC GGGGCCGGGGCAGGCCGCGCAAGCAGCCTCCGGTGAGTCCCGGGACAGCGCTGGTAGGGAGTCAGAAGGA GCCCAGCGAAGTGCCAACACCTAAGAGACCTCGGGGCCGACCAAAGGGAAGCAAAAACAAGGGTGCTGCC AAGACCCGGAAAACCACCACAACTCCAGGAAGGAAACCAAGGGGCAGACCCAAAAAACTGGAGAAGGAGG AAGAGGAGGGCATCTCGCAGGAGTCCTCGGAGGAGGAGCAGTGA    Download   Select all
CCDS ID	CCDS4789.1

Protein Information

      

Protein ID	NP_002122.1
Protein Name	High mobility group AT-hook 1
Molecular Wt. (Da)	10548
Protein Sequence	>3159 MSESSSKSSQPLASKQEKDGTEKRGRGRPRKQPPKEPSEVPTPKRPRGRPKGSKNKGAAKTRKT TTTPGRKPRGRPKKLEKEEEEGISQESSEEEQ    Download   Select all
Length	96
Uniprot ID	O43852
Ensembl Protein ID	ENSP00000249364

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	36
S	Phosphorylation	49
K	Acetylation	65
K	Acetylation	71
S	Phosphorylation	38
K	Acetylation	54
K	Acetylation	60
S	Phosphorylation	36
S	Phosphorylation	49
K	Acetylation	65
K	Acetylation	71
S	Phosphorylation	38
K	Acetylation	54
K	Acetylation	60
S	Phosphorylation	38
K	Acetylation	54
K	Acetylation	60
S	Phosphorylation	36
S	Phosphorylation	49
K	Acetylation	65
K	Acetylation	71
S	Phosphorylation	38
K	Acetylation	54
K	Acetylation	60
S	Phosphorylation	102
S	Phosphorylation	103
S	Phosphorylation	99
S	Phosphorylation	88
S	Phosphorylation	91
S	Phosphorylation	92
S	Phosphorylation	102
S	Phosphorylation	103
S	Phosphorylation	99
S	Phosphorylation	88
S	Phosphorylation	91
S	Phosphorylation	92
S	Phosphorylation	88
S	Phosphorylation	91
S	Phosphorylation	92
S	Phosphorylation	102
S	Phosphorylation	103
S	Phosphorylation	99
S	Phosphorylation	88
S	Phosphorylation	91
S	Phosphorylation	92
S	Phosphorylation	102
S	Phosphorylation	103
S	Phosphorylation	99
S	Phosphorylation	88
S	Phosphorylation	91
S	Phosphorylation	92
S	Phosphorylation	102
S	Phosphorylation	103
S	Phosphorylation	99
S	Phosphorylation	88
S	Phosphorylation	91
S	Phosphorylation	92
S	Phosphorylation	88
S	Phosphorylation	91
S	Phosphorylation	92
S	Phosphorylation	102
S	Phosphorylation	103
S	Phosphorylation	99
S	Phosphorylation	88
S	Phosphorylation	91
S	Phosphorylation	92
T	Phosphorylation	53
T	Phosphorylation	78
T	Phosphorylation	42
T	Phosphorylation	67
T	Phosphorylation	53
T	Phosphorylation	78
T	Phosphorylation	42
T	Phosphorylation	67
T	Phosphorylation	42
T	Phosphorylation	67
T	Phosphorylation	53
T	Phosphorylation	78
T	Phosphorylation	42
T	Phosphorylation	67
S	Phosphorylation	88
S	Phosphorylation	99
S	Phosphorylation	88
S	Phosphorylation	99
S	Phosphorylation	88
S	Phosphorylation	88
S	Phosphorylation	99
S	Phosphorylation	91
S	Phosphorylation	102
S	Phosphorylation	91
S	Phosphorylation	102
S	Phosphorylation	91
S	Phosphorylation	91
S	Phosphorylation	102
S	Phosphorylation	92
S	Phosphorylation	103
S	Phosphorylation	92
S	Phosphorylation	103
S	Phosphorylation	92
S	Phosphorylation	92
S	Phosphorylation	103
R	Methylation	58
R	Methylation	60
R	Methylation	58
R	Methylation	60
R	Methylation	58
R	Methylation	60
S	Phosphorylation	44;-
S	Phosphorylation	44;-
S	Phosphorylation	44;-
S	Phosphorylation	44;-
S	Phosphorylation	44;-
S	Phosphorylation	44;-
T	Phosphorylation	39;-
T	Phosphorylation	39;-
T	Phosphorylation	39;-
K	Acetylation	15
K	Acetylation	15
K	Acetylation	15
K	Acetylation	15
K	Acetylation	15
K	Acetylation	15
K	Acetylation	15
K	Acetylation	7
K	Acetylation	7
K	Acetylation	7
K	Acetylation	7
K	Acetylation	7
K	Acetylation	7
K	Acetylation	7

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                                    

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
1051	CEBPB	1801	NP_005185.2	in vitro;in vivo	12665574
1386	ATF2	443	NP_001871.2	in vitro	10357819
1387	CREBBP	2534	NP_004371.2	yeast 2-hybrid	10428837
1997	ELF1	1808	NP_758961.1	in vitro	7862168
3659	IRF1	961	NP_002189.1	in vitro	10357819
3725	JUN	1302	NP_002219.1	in vitro	10357819
4800	NFYA	1793	NP_002496.1	in vitro	9388234
5468	PPARG	3288	NP_056953.2	yeast 2-hybrid	10428835
5916	RARG	1573	NP_000957.1	yeast 2-hybrid	10428834
6256	RXRA	1577	NP_002948.1	yeast 2-hybrid	10428836
6667	SP1	1796	NP_612482.2	in vitro;in vivo	12665574
6722	SRF	2788	NP_003122.1	in vitro	9545312

Pathway Information

No matching records could be found.

Structure Information

PDB ID	2EZD
Resolution	-
Method	solution NMR
Chains	B
Molecule	DNA (5'-D(*GP*GP*GP*AP*AP*AP*TP*TP*CP*CP*TP*C)-3')
Model	View

Domain Information

No matching records could be found.

Ontology Information

   

HPRD ID	4569
Molecular Class	DNA binding protein
Molecular Function	Calcium ion binding (GO:0005509)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

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Drug Information

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External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO