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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23255232 | 2013 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and control tissue No. of Sample : - Stage : - | shRNA-mediated HMGB2 gene silencing, Luciferase reporter assay,Clonogenic assay,Immunofluorescence analysis,Western blotting,real time RT-PCR | Up-regulation | - | HMGB2 is necessary to protect colorectal cancer cells from DNA damage and efficient DNA repair and p53-mediated downregulation is a critical mechanism of modulating HMGB2 expression. |
| 20089989 | 2010 | Cell line : HCT 116, HT 29, DLD 1, HCT 8, SW480 Source : Korean Cell Line Bank (KCLB) Sample Type : - No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis and using spectral counting combined with statistics | Up-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | High-mobility group / Canonical |
| Description | This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008] | Chromosome | 4 |
| Location | 4q31 |
| Start | 173331376 |
| End | 173334444 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 3069 |
| OMIM ID | 163906 |
| HGNC ID | HGNC:5000 |
| Unigene ID | Hs.434953 |
| Ensembl ID | ENSG00000025708|ENSG00000164104 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002129.3 |
|---|---|
| Exon | join(1..173,776..945,1231..1376,1450..1624,2207..3069) | mRNA Sequence | Download Select all |
| Length | 1527 |
CDS Information
| Location | join(796..945,1231..1376,1450..1624,2207..2365) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS3816.1 |
Protein Information
| Protein ID | NP_001124160.1 |
|---|---|
| Protein Name | High-mobility group box 2 |
| Molecular Wt. (Da) | 23903 |
| Protein Sequence | Download Select all |
| Length | 209 |
| Uniprot ID | P27708 |
| Ensembl Protein ID | ENSP00000264705 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 35 |
| K | Proteolytic Cleavage | 65 |
| S | Phosphorylation | 134;- |
| K | Acetylation | 172 |
| K | Acetylation | 173 |
| K | Acetylation | 30 |
| K | Acetylation | 59 |
| K | Acetylation | 43 |
| S | Phosphorylation | 42 |
| S | Phosphorylation | 137 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 328 | APEX1 | 136 | NP_542380.1 | in vitro | 12524539 |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1UOU |
|---|---|
| Resolution | 2.11 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | THYMIDINE PHOSPHORYLASE |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01390 | 95-160 | HMGB-UBF_HMG-box |
| cl00082 | 95-160 | HMG-box superfamily |
| cd01390 | Sep-76 | HMGB-UBF_HMG-box |
| cl00082 | Sep-76 | HMG-box superfamily |
| pfam09011 | Jun-78 | HMG_box_2 |
| pfam00505 | 95-163 | HMG_box |
| cd00084 | 95-160 | HMG-box |
| smart00398 | 94-163 | HMG |
| cd00084 | Sep-76 | HMG-box |
| smart00398 | Aug-78 | HMG |
| pfam00505 | 13-78 | HMG_box |
| cd01388 | 96-165 | SOX-TCF_HMG-box |
| cd01389 | 95-163 | MATA_HMG-box |
| PTZ00199 | Mar-78 | PTZ00199 |
| pfam09011 | 93-162 | HMG_box_2 |
| PTZ00199 | 93-163 | PTZ00199 |
| cd01388 | 24-78 | SOX-TCF_HMG-box |
| COG5648 | 3-157 | NHP6B |
| COG5648 | 93-187 | NHP6B |
Ontology Information
| HPRD ID | 6437 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Ligase activity (GO:0016874) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.