Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HMGB3 | 3149 | High-mobility group box 3 | X | HMG4; HMG-4; HMG2A; HMG-2a |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and control tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis and using spectral counting combined with statistics | Down-regulation | 18,1 | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | High-mobility group / Canonical |
| Description | HMGB3 belongs to the high mobility group (HMG) protein superfamily. Like HMG1 (MIM 163905) and HMG2 (MIM 163906), HMGB3 contains DNA-binding HMG box domains and is classified into the HMG box subfamily. Members of the HMG box subfamily are thought to play a fundamental role in DNA replication, nucleosome assembly and transcription (Wilke et al., 1997 [PubMed 9370291]; Nemeth et al., 2006 [PubMed 16945912]).[supplied by OMIM, Mar 2008] | Chromosome | X |
| Location | Xq28 |
| Start | 150980508 |
| End | 150990775 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 10268 |
| OMIM ID | 300193 |
| HGNC ID | HGNC:5004 |
| Unigene ID | Hs.19114 |
| Ensembl ID | ENSG00000029993 |
| PharmGKB ID | PA35092 |
mRNA Information
| mRNA ID | NM_001301231.1 |
|---|---|
| Exon | join(1..137,5088..5242,5544..5683,6621..6795,7270..10268) | mRNA Sequence | Download Select all |
| Length | 3556 |
CDS Information
| Location | join(83..137,5088..5242,5544..5683,6621..6795,7270..7407) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001288157.1 |
|---|---|
| Protein Name | High-mobility group box 3 |
| Molecular Wt. (Da) | 22849 |
| Protein Sequence | Download Select all |
| Length | 200 |
| Uniprot ID | P22676 |
| Ensembl Protein ID | ENSP00000307508 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 59 |
| K | Acetylation | 145 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01390 | 93-158 | HMGB-UBF_HMG-box |
| cl00082 | 93-158 | HMG-box superfamily |
| cd01390 | 13-76 | HMGB-UBF_HMG-box |
| cl00082 | 13-76 | HMG-box superfamily |
| pfam09011 | 13-78 | HMG_box_2 |
| pfam00505 | 93-161 | HMG_box |
| cd00084 | 93-158 | HMG-box |
| smart00398 | 92-161 | HMG |
| cd00084 | 13-76 | HMG-box |
| smart00398 | 13-78 | HMG |
| pfam09011 | 90-161 | HMG_box_2 |
| pfam00505 | 13-78 | HMG_box |
| cd01388 | 94-161 | SOX-TCF_HMG-box |
| PTZ00199 | 89-160 | PTZ00199 |
| cd01389 | 93-161 | MATA_HMG-box |
| PTZ00199 | 13-78 | PTZ00199 |
| cd01388 | 13-78 | SOX-TCF_HMG-box |
| COG5648 | 13-155 | NHP6B |
| COG5648 | 89-174 | NHP6B |
Ontology Information
| HPRD ID | 230 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Calcium ion binding (GO:0005509) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.