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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11179495 | 2001 | Cell line : COLO 205,HT 29 Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR | Down-regulation | - | Hox A5 expression was increased when COLO 205 cells were induced to differentiate. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / ANTP class : HOXL subclass |
| Description | In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008] | Chromosome | 7 |
| Location | 7p15.2 |
| Start | 27180671 |
| End | 27192309 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 11639 |
| OMIM ID | 142952 |
| HGNC ID | HGNC:5106 |
| Unigene ID | Hs.655218 |
| Ensembl ID | ENSG00000106004 |
| PharmGKB ID | PA29383 |
mRNA Information
| mRNA ID | NM_019102.3 |
|---|---|
| Exon | join(1..623,1584..2617) | mRNA Sequence | Download Select all |
| Length | 1657 |
Protein Information
| Protein ID | NP_061975.2 |
|---|---|
| Protein Name | homeobox A5 |
| Molecular Wt. (Da) | 29214 |
| Protein Sequence | Download Select all |
| Length | 270 |
| Uniprot ID | P34741 |
| Ensembl Protein ID | ENSP00000307046 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 147 |
| S | Phosphorylation | 156 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2308 | FOXO1 | 645 | NP_002006.2 | in vivo | 12163409 |
| 7291 | TWIST1 | 3374 | NP_000465.1 | in vitro;in vivo;yeast 2-hybrid | 15545268 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 196-254 | homeodomain |
| cl00084 | 196-254 | homeodomain superfamily |
| pfam00046 | 196-252 | Homeobox |
| smart00389 | 195-251 | HOX |
| COG5576 | 193-260 | COG5576 |
Ontology Information
| HPRD ID | 3741 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.