Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HRH4 | 59340 | histamine receptor H4 | 18 | H4R, HH4R, AXOR35, GPCR105, GPRv53 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21609450 | 2011 | Cell line : Colo 320, Lovo Source : Department of Biochemistry, Hong Kong University of Science and Technology.CRC samples were obtained Department of Gastroenterology, Shenzhen Hospital, Peking University. Sample Type : CRC tumor and normal tissue No. of Sample : 107 Stage : - | Immunoblotting, real-time PCR, immunofluorescence and immunohistochemistry | Down-regulation | - | Expression levels of HRH4 could influence the histamine-mediated growth regulation in CRC cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Histamine receptors |
| Description | Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] | Chromosome | 18 |
| Location | 18q11.2 |
| Start | 22040593 |
| End | 22059921 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 19329 |
| OMIM ID | 606792 |
| HGNC ID | HGNC:17383 |
| Unigene ID | Hs.287388 |
| Ensembl ID | ENSG00000134489 |
| PharmGKB ID | PA134982275 |
Protein Information
| Protein ID | NP_001137300.1 |
|---|---|
| Protein Name | histamine receptor H4 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 390 |
| Uniprot ID | Q9HB09 |
| Ensembl Protein ID | ENSP00000246785 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2769 | GNA15 | 760 | NP_002059.2 | in vivo | 10973974 |
| 2770 | GNAI1 | 756 | NP_002060.4 | in vivo | 10973974 |
| 2775 | GNAO1 | 757 | NP_066268.1 | in vivo | 10973974 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Neuroactive ligand-receptor interaction | hsa04080 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00001 | 38-358 | 7tm_1 |
| PHA03087 | 7-201 | PHA03087 |
| PHA02834 | 4-153 | PHA02834 |
| PHA02638 | 30-156 | PHA02638 |
Ontology Information
| HPRD ID | 15683 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q9H3N8 | DB00321 | Amitriptyline | SmallMoleculeDrug |
| Q9H3N8 | DB00334 | Olanzapine | SmallMoleculeDrug |
| Q9H3N8 | DB00363 | Clozapine | SmallMoleculeDrug |
| Q9H3N8 | DB00408 | Loxapine | SmallMoleculeDrug |
| Q9H3N8 | DB00477 | Chlorpromazine | SmallMoleculeDrug |
| Q9H3N8 | DB00543 | Amoxapine | SmallMoleculeDrug |
| Q9H3N8 | DB00667 | Histamine Phosphate | SmallMoleculeDrug |
| Q9H3N8 | DB01142 | Doxepin | SmallMoleculeDrug |
| Q9H3N8 | DB06148 | Mianserin | SmallMoleculeDrug |