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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 14695142 | 2003 | Cell line : Caco2, RKO, SW48, HCT116, DLD-1, LoVo, HT29, Colo205, Colo201, SW480, Colo320DM Source : - Sample Type : - No. of Sample : - Stage : - | Bisulfite-PCR and bisulfite sequencing,RT-PCR and chromatin immunoprecipitation ,fluorescence-activated cell-sorting analysis | Hypermethylation | - | HRK methylation can be a useful molecular target for cancer therapy in a subset of colorectal and gastric cancers. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012] | Chromosome | 12 |
| Location | 12q24.2 |
| Start | 117298225 |
| End | 117319232 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 21008 |
| OMIM ID | 603447 |
| HGNC ID | HGNC:5185 |
| Unigene ID | Hs.87247 |
| Ensembl ID | - |
| PharmGKB ID | PA29459 |
Protein Information
| Protein ID | NP_003797.1 |
|---|---|
| Protein Name | harakiri, BCL2 interacting protein |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 91 |
| Uniprot ID | Q9UDY4 |
| Ensembl Protein ID | ENSP00000359799 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 572 | BAD | 4409 | NP_004313.1 | in vitro;yeast 2-hybrid | 11483855 |
| 596 | BCL2 | 1045 | NP_000624.2 | in vivo;yeast 2-hybrid | 913 071 310 075 695 |
| 597 | BCL2A1 | 3034 | NP_004040.1 | in vitro | 15694340 |
| 598 | BCL2L1 | 2497 | NP_612815.1 | in vitro;in vivo | 1 007 569 591 307 130 000 000 000 000 000 |
| 708 | C1QBP | 3168 | NP_001203.1 | in vitro;yeast 2-hybrid | 15031724 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam15196 | Jan-91 | Harakiri |
| cl21061 | Jan-91 | Harakiri superfamily |
Ontology Information
| HPRD ID | 5420 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | Metallopeptidase activity (GO:0008237) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.