Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HS3ST2 | 9956 | heparan sulfate (glucosamine) 3-O-sulfotransferase 2 | 16 | 3OST2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21187457 | 2010 | Cell line : - Source : ATCC, Department of Surgical oncology at the Gifu University hospital Sample Type : CRC tumor and normal tissue No. of Sample : 129 Stage : - | RT-PCR, methylation-specific PCR | Methylation | - | Results may show the possibility of early detection for CRC by examining 3OST2 gene methylation status in DNA extracted from stool. The 3OST2 gene was the most frequently methylated (57%) and was methylated frequently (9/21, 43%) in bowel lavage but rarely (1/21; 4.7%) in the venous drainage. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Sulfotransferases, membrane-bound |
| Description | Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system. | Chromosome | 16 |
| Location | 16p12 |
| Start | 22814203 |
| End | 22916338 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 102136 |
| OMIM ID | 604056 |
| HGNC ID | HGNC:5195 |
| Unigene ID | Hs.115830 |
| Ensembl ID | ENSG00000122254 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011546002.1 |
|---|---|
| Exon | join(1..893,61929..62060) | mRNA Sequence | Download Select all |
| Length | 1968 |
CDS Information
| Location | join(409..893,100742..101360) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS10606.1 |
Protein Information
| Protein ID | NP_006034.1 |
|---|---|
| Protein Name | heparan sulfate (glucosamine) 3-O-sulfotransferase 2 |
| Molecular Wt. (Da) | 41370 |
| Protein Sequence | Download Select all |
| Length | 367 |
| Uniprot ID | O43187 |
| Ensembl Protein ID | ENSP00000256458 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
| EC | 2.8.2.29 |
|---|---|
| Name | [heparan sulfate]-glucosamine 3-sulfotransferase 2 glucosaminyl 3-O-sulfotransferase heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoform/isozyme 2 (3-OST-2, HS3ST2) |
| Class | Transferases; Transferring sulfur-containing groups; Sulfotransferases |
| Sysname | 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase |
| Substrate | 3'-phosphoadenylyl sulfate [CPD:C00053]; [heparan sulfate]-glucosamine [CPD:C17141] |
| Product | adenosine 3',5'-bisphosphate [CPD:C00054]; [heparan sulfate]-glucosamine 3-sulfate [CPD:C11553] |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Glycosaminoglycan biosynthesis - heparan sulfate / heparin | hsa00534 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00685 | 114-351 | Sulfotransfer_1 |
| cl21551 | 114-351 | Sulfotransfer_1 superfamily |
| pfam03567 | 143-350 | Sulfotransfer_2 |
| cl22970 | 143-350 | Sulfotransfer_2 superfamily |
Ontology Information
| HPRD ID | 4769 |
|---|---|
| Molecular Class | Enzyme: Sulphotransferase |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.