Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HSD17B1 | 3292 | hydroxysteroid (17-beta) dehydrogenase 1 | 17 | HSD17, MGC138140, SDR28C1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22176788 | 2011 | Cell line : HT29, SW707 Source : - Sample Type : - No. of Sample : - Stage : - | PCR and western blotting ,Chromatin immunoprecepetation,electrochemiluminescence | Down-regulation | - | Reduced HSD17B1 expression can be associated with DNA methylation in the 5' flanking region of HSD17B1 in CRC from the proximal colon. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 2 |
| Description | - | Chromosome | 17 |
| Location | 17q11-q21 |
| Start | 40703984 |
| End | 40707232 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3249 |
| OMIM ID | 109684 |
| HGNC ID | HGNC:5210 |
| Unigene ID | Hs.654385 |
| Ensembl ID | - |
| PharmGKB ID | PA29478 |
mRNA Information
| mRNA ID | XM_006721857.2 |
|---|---|
| Exon | join(1..1349,1497..1676,1852..1945,2460..3272) | mRNA Sequence | Download Select all |
| Length | 2436 |
Protein Information
| Protein ID | XP_006721920.1 |
|---|---|
| Protein Name | hydroxysteroid (17-beta) dehydrogenase 1 |
| Molecular Wt. (Da) | 43946 |
| Protein Sequence | Download Select all |
| Length | 415 |
| Uniprot ID | Q13275 |
| Ensembl Protein ID | ENSP00000002829 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Metabolic pathways | hsa01100 |
| Ovarian steroidogenesis | hsa04913 |
| Steroid hormone biosynthesis | hsa00140 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd09806 | 4-261 | type1_17beta-HSD-like_SDR_c |
| cl21454 | 4-261 | NADB_Rossmann superfamily |
| cd05374 | 5-261 | 17beta-HSD-like_SDR_c |
| cd02266 | 6-256 | SDR |
| cd05233 | 6-248 | SDR_c |
| PRK05993 | 1-262 | PRK05993 |
| cd05332 | 5-211 | 11beta-HSD1_like_SDR_c |
| cd09805 | 6-187 | type2_17beta_HSD-like_SDR_c |
| cd08939 | 4-184 | KDSR-like_SDR_c |
| PRK06482 | 1-215 | PRK06482 |
| PRK08017 | 6-257 | PRK08017 |
| cd05346 | 6-193 | SDR_c5 |
| cd08932 | 5-197 | HetN_like_SDR_c |
| cd05323 | 5-249 | ADH_SDR_c_like |
| cd05354 | 5-239 | SDR_c7 |
| cd05350 | 6-201 | SDR_c6 |
| cd05366 | 5-238 | meso-BDH-like_SDR_c |
| cd05339 | 5-197 | 17beta-HSDXI-like_SDR_c |
| cd05333 | 5-204 | BKR_SDR_c |
| PRK07832 | 6-246 | PRK07832 |
| cd05325 | 6-191 | carb_red_sniffer_like_SDR_c |
| cd08934 | 1-205 | CAD_SDR_c |
| cd05324 | 5-193 | carb_red_PTCR-like_SDR_c |
| cd05347 | 5-208 | Ga5DH-like_SDR_c |
| cd05360 | 5-197 | SDR_c3 |
| cd05370 | 6-197 | SDR_c2 |
| cd05368 | 5-205 | DHRS6_like_SDR_c |
| cd08929 | 6-252 | SDR_c4 |
| cd05330 | 5-198 | cyclohexanol_reductase_SDR_c |
| cd05331 | 6-192 | DH-DHB-DH_SDR_c |
| cd05341 | 5-208 | 3beta-17beta-HSD_like_SDR_c |
| cd05359 | 6-208 | ChcA_like_SDR_c |
| cd08931 | 6-196 | SDR_c9 |
| cd05356 | 4-225 | 17beta-HSD1_like_SDR_c |
| cd05362 | 5-193 | THN_reductase-like_SDR_c |
| cd05344 | 5-207 | BKR_like_SDR_like |
| cd05338 | 1-179 | DHRS1_HSDL2-like_SDR_c |
| cd08945 | 1-240 | PKR_SDR_c |
| cd05364 | 1-242 | SDR_c11 |
| cd05327 | 5-163 | retinol-DH_like_SDR_c_like |
| cd05369 | 5-203 | TER_DECR_SDR_a |
| cd05343 | 5-248 | Mgc4172-like_SDR_c |
| cd05373 | 5-193 | SDR_c10 |
| cd08942 | 1-202 | RhlG_SDR_c |
| cd08940 | 5-242 | HBDH_SDR_c |
| cd05345 | 5-202 | BKR_3_SDR_c |
| PRK06550 | 5-192 | fabG |
| cd05349 | 5-206 | BKR_2_SDR_c |
| cd08936 | 1-193 | CR_SDR_c |
| cd05351 | 5-176 | XR_like_SDR_c |
| cd05352 | 5-192 | MDH-like_SDR_c |
| cd05363 | 5-197 | SDH_SDR_c |
| cd05358 | 5-202 | GlcDH_SDR_c |
| PRK07523 | 7-171 | PRK07523 |
| cd05326 | 5-207 | secoisolariciresinol-DH_like_SDR_c |
| PRK08177 | 6-183 | PRK08177 |
| cd05365 | 5-202 | 7_alpha_HSDH_SDR_c |
| PRK06101 | 4-196 | PRK06101 |
| PRK07069 | 7-193 | PRK07069 |
| cd08944 | 5-171 | SDR_c12 |
| cd08935 | 5-202 | mannonate_red_SDR_c |
| PRK08945 | 83-171 | PRK08945 |
| cd05357 | 5-176 | PR_SDR_c |
| cd05367 | 5-171 | SPR-like_SDR_c |
| cd09810 | 6-165 | LPOR_like_SDR_c_like |
| cd08941 | 3-200 | 3KS_SDR_c |
| cd05328 | 5-147 | 3alpha_HSD_SDR_c |
| cd08943 | 5-184 | R1PA_ADH_SDR_c |
| cd05340 | 5-192 | Ycik_SDR_c |
| PRK08251 | 3-204 | PRK08251 |
| cd05329 | 6-238 | TR_SDR_c |
| PRK05876 | 7-184 | PRK05876 |
| PRK12935 | 5-204 | PRK12935 |
| cd08937 | 5-171 | DHB_DH-like_SDR_c |
| PRK12746 | 5-202 | PRK12746 |
| cd05355 | 5-242 | SDR_c1 |
| cd08930 | 5-189 | SDR_c8 |
| cd05353 | 5-206 | hydroxyacyl-CoA-like_DH_SDR_c-like |
| cd05337 | 3-197 | BKR_1_SDR_c |
| cd05322 | 3-201 | SDH_SDR_c_like |
| PRK07102 | 6-204 | PRK07102 |
| cd05371 | 5-203 | HSD10-like_SDR_c |
| cd05361 | 82-203 | haloalcohol_DH_SDR_c-like |
| cd09761 | 5-176 | A3DFK9-like_SDR_c |
| PRK07904 | 6-210 | PRK07904 |
| PRK07453 | 6-144 | PRK07453 |
| cd09763 | 1-179 | DHRS1-like_SDR_c |
| PRK08085 | 6-171 | PRK08085 |
| cd11730 | 6-253 | Tthb094_like_SDR_c |
| PRK12859 | 5-194 | PRK12859 |
| cd05348 | 5-176 | BphB-like_SDR_c |
| cd09807 | 5-162 | retinol-DH_like_SDR_c |
| PLN00015 | 7-146 | PLN00015 |
| PRK06947 | 3-191 | PRK06947 |
| cd05240 | 6-185 | UDP_G4E_3_SDR_e |
| cd08953 | 5-149 | KR_2_SDR_x |
| smart00822 | 5-151 | PKS_KR |
| cd08933 | 5-203 | RDH_SDR_c |
| PRK12747 | 5-216 | PRK12747 |
| pfam13561 | 65-191 | adh_short_C2 |
| cd09762 | 6-139 | HSDL2_SDR_c |
| cd11731 | 6-145 | Lin1944_like_SDR_c |
| PRK06953 | 5-163 | PRK06953 |
| PRK09730 | 5-207 | PRK09730 |
| TIGR01289 | Jun-94 | LPOR |
| cd05274 | 6-168 | KR_FAS_SDR_x |
| PRK08703 | 1-191 | PRK08703 |
| cd05334 | 5-172 | DHPR_SDR_c_like |
| cd08951 | 1-117 | DR_C-13_KR_SDR_c_like |
| PRK07806 | 5-141 | PRK07806 |
| cd05227 | 5-154 | AR_SDR_e |
| PRK05854 | Jul-94 | PRK05854 |
| PRK05599 | 6-188 | PRK05599 |
| cd05372 | 62-204 | ENR_SDR |
| PRK07023 | 49-164 | PRK07023 |
| PRK07889 | 6-191 | PRK07889 |
| pfam08659 | 5-176 | KR |
| PRK06123 | 2-191 | PRK06123 |
| PRK08415 | 58-191 | PRK08415 |
| PRK07578 | 63-135 | PRK07578 |
| PRK06940 | 2-148 | PRK06940 |
| cd05243 | 6-146 | SDR_a5 |
| cd09809 | 5-143 | human_WWOX_like_SDR_c-like |
| cd05226 | 6-164 | SDR_e_a |
| cd08946 | 113-241 | SDR_e |
| cd05257 | 6-241 | Arna_like_SDR_e |
| COG4221 | 5-251 | YdfG |
| PRK06914 | 1-254 | PRK06914 |
| PRK06179 | 1-254 | PRK06179 |
| PRK06180 | 1-253 | PRK06180 |
| PRK06182 | 1-267 | PRK06182 |
| PRK08263 | 1-265 | PRK08263 |
| PRK12826 | 5-204 | PRK12826 |
| COG1028 | 1-265 | FabG |
| COG0300 | 1-252 | DltE |
| PRK05693 | 5-264 | PRK05693 |
| PRK09291 | 1-206 | PRK09291 |
| PRK05653 | 1-204 | fabG |
| TIGR03971 | 5-179 | SDR_subfam_1 |
| PRK12825 | 1-204 | fabG |
| PRK05557 | 5-242 | fabG |
| PRK08264 | 4-207 | PRK08264 |
| PRK12829 | 5-197 | PRK12829 |
| PRK07231 | 5-203 | fabG |
| PRK06841 | 5-179 | PRK06841 |
| PRK06181 | 3-212 | PRK06181 |
| PRK07326 | 5-193 | PRK07326 |
| TIGR02415 | 5-240 | 23BDH |
| pfam00106 | 5-175 | adh_short |
| TIGR01963 | 5-203 | PHB_DH |
| PRK08267 | 6-172 | PRK08267 |
| PRK07024 | 6-179 | PRK07024 |
| PRK09072 | 6-180 | PRK09072 |
| PRK05650 | 6-184 | PRK05650 |
| PRK05565 | 5-242 | fabG |
| PRK06500 | 6-208 | PRK06500 |
| PRK12939 | 5-238 | PRK12939 |
| PRK12827 | 5-204 | PRK12827 |
| PRK07825 | 5-184 | PRK07825 |
| TIGR04316 | 6-192 | dhbA_paeA |
| PRK12824 | 5-207 | PRK12824 |
| PRK08220 | 5-179 | PRK08220 |
| PRK07666 | 5-171 | fabG |
| PRK08226 | 5-206 | PRK08226 |
| PRK07577 | 1-203 | PRK07577 |
| PRK08219 | 1-170 | PRK08219 |
| PRK07109 | 1-198 | PRK07109 |
| TIGR01830 | 6-204 | 3oxo_ACP_reduc |
| PRK12828 | 4-207 | PRK12828 |
| PRK08643 | 5-197 | PRK08643 |
| PRK06138 | 5-242 | PRK06138 |
| PRK07067 | 5-197 | PRK07067 |
| PRK07060 | 5-202 | PRK07060 |
| PRK12429 | 5-206 | PRK12429 |
| TIGR01829 | 5-206 | AcAcCoA_reduct |
| PRK12937 | 2-192 | PRK12937 |
| PRK08063 | 1-191 | PRK08063 |
| PRK05872 | 1-185 | PRK05872 |
| PRK08324 | 2-179 | PRK08324 |
| PRK07890 | 5-208 | PRK07890 |
| PRK06463 | 5-215 | fabG |
| PRK12742 | 6-204 | PRK12742 |
| PRK07775 | 2-192 | PRK07775 |
| PRK06139 | 5-195 | PRK06139 |
| PRK06124 | 5-179 | PRK06124 |
| PRK07831 | 5-242 | PRK07831 |
| PRK06172 | 5-242 | PRK06172 |
| PRK13394 | 5-196 | PRK13394 |
| PRK06398 | 5-247 | PRK06398 |
| PRK08213 | 5-213 | PRK08213 |
| TIGR04504 | 3-195 | SDR_subfam_2 |
| PRK07677 | 5-119 | PRK07677 |
| PRK07454 | 6-171 | PRK07454 |
| PRK07062 | 1-192 | PRK07062 |
| PRK07201 | 5-165 | PRK07201 |
| PRK05867 | 7-242 | PRK05867 |
| PRK07063 | 5-248 | PRK07063 |
| PRK12743 | 2-179 | PRK12743 |
| PRK06484 | 5-206 | PRK06484 |
| PRK12384 | 5-201 | PRK12384 |
| PRK07478 | 5-202 | PRK07478 |
| PRK10538 | 5-160 | PRK10538 |
| PRK06484 | 3-191 | PRK06484 |
| TIGR02632 | 1-179 | RhaD_aldol-ADH |
| PRK08642 | 4-206 | fabG |
| TIGR03206 | 5-202 | benzo_BadH |
| PRK06701 | 5-191 | PRK06701 |
| PRK08265 | 5-242 | PRK08265 |
| PRK06935 | 5-207 | PRK06935 |
| PRK06523 | 6-191 | PRK06523 |
| PRK07074 | 2-191 | PRK07074 |
| PRK09242 | 7-208 | PRK09242 |
| PRK06194 | 5-170 | PRK06194 |
| COG0451 | 6-272 | WcaG |
| TIGR01832 | 5-207 | kduD |
| PRK05855 | 4-269 | PRK05855 |
| TIGR01831 | 6-204 | fabG_rel |
| PRK06114 | 5-187 | PRK06114 |
| PRK08278 | 3-139 | PRK08278 |
| PRK06125 | 6-198 | PRK06125 |
| PRK06949 | 5-191 | PRK06949 |
| PRK07856 | 5-202 | PRK07856 |
| PRK12748 | 5-194 | PRK12748 |
| PRK12936 | 7-197 | PRK12936 |
| COG3967 | 6-163 | DltE |
| PRK07035 | 5-179 | PRK07035 |
| PRK08628 | 5-205 | PRK08628 |
| PRK06198 | 4-176 | PRK06198 |
| PRK06171 | 5-179 | PRK06171 |
| PRK07774 | 5-206 | PRK07774 |
| PRK12745 | 2-179 | PRK12745 |
| PRK06057 | 5-211 | PRK06057 |
| PRK05866 | 6-180 | PRK05866 |
| PRK06077 | 5-251 | fabG |
| PRK12938 | 1-204 | PRK12938 |
| PRK07576 | 6-189 | PRK07576 |
| PRK05875 | 1-202 | PRK05875 |
| PRK08589 | 5-242 | PRK08589 |
| PRK07097 | 5-171 | PRK07097 |
| PRK08277 | 5-172 | PRK08277 |
| PRK07041 | 7-179 | PRK07041 |
| PRK08261 | 5-179 | fabG |
| PRK05717 | 5-176 | PRK05717 |
| PRK08217 | 5-204 | fabG |
| PRK09135 | 1-176 | PRK09135 |
| PRK06200 | 5-176 | PRK06200 |
| TIGR03325 | 5-177 | BphB_TodD |
| PRK06113 | 5-202 | PRK06113 |
| pfam01370 | 6-171 | Epimerase |
| PRK08936 | 5-204 | PRK08936 |
| PLN02253 | 5-209 | PLN02253 |
| PRK12481 | 5-191 | PRK12481 |
| PRK07370 | 43-191 | PRK07370 |
| COG0623 | 7-191 | FabI |
| PRK05786 | 6-179 | fabG |
| PRK06197 | May-93 | PRK06197 |
| PRK06128 | 7-203 | PRK06128 |
| PLN02780 | 7-160 | PLN02780 |
| TIGR02685 | 5-187 | pter_reduc_Leis |
| PRK07814 | 5-202 | PRK07814 |
| PRK08993 | 5-207 | PRK08993 |
| PRK12823 | 5-171 | benD |
Ontology Information
| HPRD ID | 3213 |
|---|---|
| Molecular Class | Enzyme: Dehydrogenase |
| Molecular Function | Protein threonine/tyrosine kinase activity (GO:0004712) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P14061 | DB02187 | Equilin | SmallMoleculeDrug |