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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HSP90B1 | 7184 | heat shock protein 90kDa beta (Grp94), member 1  | 12 | GP96, GRP94  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23567825    | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Lectin microarray, lectin histochemistry and nano liquid chromatography-mass spectrometry/mass spectrometry (nanoLC-MS/MS) | Up-regulation | - | Annexin A1 and HSP90? were GlcNAcylated, and their protein expressions were elevated in colon cancer, compared to normal tissues. Specific changes of GlcNAc abundances in Annexin A1 and HSP90? suggested that tumor-specific glycan patterns could serve as candidate biomarkers of colon cancer for distinguishing cancer patients from healthy individuals. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Heat shock proteins / HSPC |
| Description | This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15.   | Chromosome | 12 |
| Location | 12q24.2-q2 |
| Start | 103930334   |
| End | 103947930   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 17597   |
| OMIM ID | 191175    |
| HGNC ID | HGNC:12028    |
| Unigene ID | Hs.192374    |
| Ensembl ID | ENSG00000166598    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_003299.2 |
|---|---|
| Exon | join(1..231,1188..1290,1944..2085,2493..2609,3623..3954, 7362..7473,8007..8126,9176..9292,11077..11214, 11296..11373,11499..11564,12194..12463,12741..12986, 13405..13541,16285..16363,16453..16608,16978..17097, 17300..17597)   | mRNA Sequence |    Download   Select all |
| Length | 2879   |
CDS Information
| Location | join(183..231,1188..1290,1944..2085,2493..2609,3623..3954, 7362..7473,8007..8126,9176..9292,11077..11214, 11296..11373,11499..11564,12194..12463,12741..12986, 13405..13541,16285..16363,16453..16608,16978..17097, 17300..17329) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS9094.1 |    
Protein Information
| Protein ID | NP_003290.1 |
|---|---|
| Protein Name | heat shock protein 90kDa beta (Grp94), member 1 |
| Molecular Wt. (Da) | 90178 |
| Protein Sequence |    Download   Select all |
| Length | 803   |
| Uniprot ID | O14920 |    
| Ensembl Protein ID | ENSP00000404920   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 677;- |
| T | Phosphorylation | 786 |
| S | Phosphorylation | 306 |
| T | Phosphorylation | 604 |
| T | Phosphorylation | 774 |
| T | Phosphorylation | 792 |
| S | Phosphorylation | 92 |
| Y | Phosphorylation | 94 |
| T | Phosphorylation | 684 |
| T | Phosphorylation | 148 |
| T | Phosphorylation | 150 |
| S | Phosphorylation | 515 |
| T | Phosphorylation | 519 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 338 |    APOB |    133 |    NP_000375.2 |    in vitro;in vivo |    12397072    |
| 432 |    ASGR1 |    151 |    NP_001662.1 |    in vivo |    12167617    |
| 1457 |    CSNK2A1 |    277 |    NP_001886.1 |    in vitro |    11557039    |
| 1459 |    CSNK2A2 |    279 |    NP_001887.1 |    in vitro |    11557039    |
| 2064 |    ERBB2 |    1281 |    NP_004439.2 |    in vitro |    8617772    |
| 4035 |    LRP1 |    138 |    NP_002323.2 |    in vivo |    11861214    |
| 4547 |    MTTP |    1144 |    NP_000244.2 |    in vivo |    9694898    |
| 7038 |    TG |    1782 |    NP_003226.4 |    in vitro |    10049727    |
| 7096 |    TLR1 |    3119 |    NP_003254.2 |    in vivo |    11584270    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Estrogen signaling pathway |    hsa04915 |    
| NOD-like receptor signaling pathway |    hsa04621 |    
| Pathways in cancer |    hsa05200 |    
| PI3K-Akt signaling pathway |    hsa04151 |    
| Prostate cancer |    hsa05215 |    
| Protein processing in endoplasmic reticulum |    hsa04141 |    
| Thyroid hormone synthesis |    hsa04918 |    
Structure Information
| PDB ID | 4NH9 |
|---|---|
| Resolution | 2.77 |
| Method | ?? X-RAY DIFFRACTION |
| Chains | A   |
| Molecule | Endoplasmin   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00075 | 98-251  | HATPase_c |
| cl00075 | 98-251  | HATPase_c superfamily |
| pfam00183 | 257-755  | HSP90 |
| cl20204 | 257-755  | HSP90 superfamily |
| pfam02518 | 96-254  | HATPase_c |
| smart00387 | 96-254  | HATPase_c |
| pfam13589 | 101-221  | HATPase_c_3 |
| pfam03896 | Apr-54  | TRAP_alpha |
| cl04314 | Apr-54  | TRAP_alpha superfamily |
| PRK05218 | 74-746  | PRK05218 |
| PTZ00272 | 73-754  | PTZ00272 |
| COG0326 | 72-748  | HtpG |
| PTZ00130 | 9-755  | PTZ00130 |
| PRK14083 | 77-464  | PRK14083 |
Ontology Information
| HPRD ID | 985 |    
|---|---|
| Molecular Class | Heat shock protein |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Immune response (GO:0006955)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P14625 | DB00615 | Rifabutin | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
