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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
HSP90B1 7184 heat shock protein 90kDa beta (Grp94), member 1  12GP96, GRP94 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23567825   2013Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

Lectin microarray, lectin histochemistry and nano liquid chromatography-mass spectrometry/mass spectrometry (nanoLC-MS/MS)Up-regulation-Annexin A1 and HSP90? were GlcNAcylated, and their protein expressions were elevated in colon cancer, compared to normal tissues.

Specific changes of GlcNAc abundances in Annexin A1 and HSP90? suggested that tumor-specific glycan patterns could serve as candidate biomarkers of colon cancer for distinguishing cancer patients from healthy individuals.


Gene Details



Chromosome 12 - NC_000012.12 (103930334..103947930)

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Gene Type protein coding
Gene Family Heat shock proteins / HSPC
Description This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15.  
Chromosome 12
Location 12q24.2-q2
Start 103930334  
End 103947930  
Strand +  
Gene Sequence

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Length 17597  
OMIM ID 191175   
HGNC ID HGNC:12028   
Unigene ID Hs.192374   
Ensembl ID ENSG00000166598   
PharmGKB ID -   

mRNA Information


mRNA ID NM_003299.2
Exon join(1..231,1188..1290,1944..2085,2493..2609,3623..3954, 7362..7473,8007..8126,9176..9292,11077..11214, 11296..11373,11499..11564,12194..12463,12741..12986, 13405..13541,16285..16363,16453..16608,16978..17097, 17300..17597)  
mRNA Sequence

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Length 2879  



CDS Information


   
Locationjoin(183..231,1188..1290,1944..2085,2493..2609,3623..3954, 7362..7473,8007..8126,9176..9292,11077..11214, 11296..11373,11499..11564,12194..12463,12741..12986, 13405..13541,16285..16363,16453..16608,16978..17097, 17300..17329)
CDS Sequence

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CCDS ID CCDS9094.1



Protein Information


      
Protein IDNP_003290.1
Protein Nameheat shock protein 90kDa beta (Grp94), member 1
Molecular Wt. (Da)90178
Protein Sequence

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Length 803  
Uniprot IDO14920
Ensembl Protein ID ENSP00000404920  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation677;-
TPhosphorylation786
SPhosphorylation306
TPhosphorylation604
TPhosphorylation774
TPhosphorylation792
SPhosphorylation92
YPhosphorylation94
TPhosphorylation684
TPhosphorylation148
TPhosphorylation150
SPhosphorylation515
TPhosphorylation519

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
338APOB133NP_000375.2in vitro;in vivo12397072   
432ASGR1151NP_001662.1in vivo12167617   
1457CSNK2A1277NP_001886.1in vitro11557039   
1459CSNK2A2279NP_001887.1in vitro11557039   
2064ERBB21281NP_004439.2in vitro8617772   
4035LRP1138NP_002323.2in vivo11861214   
4547MTTP1144NP_000244.2in vivo9694898   
7038TG1782NP_003226.4in vitro10049727   
7096TLR13119NP_003254.2in vivo11584270   


Pathway Information


                                          
Pathway Name Pathway ID
Estrogen signaling pathway hsa04915
NOD-like receptor signaling pathway hsa04621
Pathways in cancer hsa05200
PI3K-Akt signaling pathway hsa04151
Prostate cancer hsa05215
Protein processing in endoplasmic reticulum hsa04141
Thyroid hormone synthesis hsa04918


Structure Information


PDB ID4NH9
Resolution2.77
Method?? X-RAY DIFFRACTION
Chains A  
Molecule Endoplasmin  
Model View



Domain Information




ID Location Description
cd0007598-251  HATPase_c
cl0007598-251  HATPase_c superfamily
pfam00183257-755  HSP90
cl20204257-755  HSP90 superfamily
pfam0251896-254  HATPase_c
smart0038796-254  HATPase_c
pfam13589101-221  HATPase_c_3
pfam03896Apr-54  TRAP_alpha
cl04314Apr-54  TRAP_alpha superfamily
PRK0521874-746  PRK05218
PTZ0027273-754  PTZ00272
COG032672-748  HtpG
PTZ001309-755  PTZ00130
PRK1408377-464  PRK14083


Ontology Information


   
HPRD ID985
Molecular ClassHeat shock protein
Molecular FunctionCytokine activity (GO:0005125)
Biological ProcessImmune response (GO:0006955)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P14625DB00615RifabutinSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO