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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HSPA1A | 3303 | Heat shock 70kDa protein 1A | 6 | HSP72; HSPA1; HSP70I; HSP70-1; HSP70-1A |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and control tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis and using spectral counting combined with statistics | Up-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Heat shock proteins / HSP70 |
| Description | This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008] | Chromosome | 6 |
| Location | 6p21.3 |
| Start | 31815514 |
| End | 31817942 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 2429 |
| OMIM ID | 140550 |
| HGNC ID | HGNC:5232 |
| Unigene ID | Hs.274402 |
| Ensembl ID | ENSG00000204389 |
| PharmGKB ID | PA29498 |
Protein Information
| Protein ID | NP_005336.3 |
|---|---|
| Protein Name | Heat shock 70kDa protein 1A |
| Molecular Wt. (Da) | 69921 |
| Protein Sequence | Download Select all |
| Length | 641 |
| Uniprot ID | |
| Ensembl Protein ID |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 631;- |
| Y | Phosphorylation | 611 |
| K | Acetylation | 500 |
| K | Acetylation | 319 |
| K | Acetylation | 348 |
| K | Acetylation | 246 |
| K | Acetylation | 108 |
| S | Phosphorylation | 633 |
| T | Phosphorylation | 222 |
| S | Phosphorylation | 608 |
| T | Phosphorylation | 636 |
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 328 | APEX1 | 136 | NP_542380.1 | in vitro;in vivo | 1 113 399 210 629 610 |
| 338 | APOB | 133 | NP_000375.2 | in vitro | 9252351 |
| 1728 | NQO1 | 518 | NP_000894.1 | in vitro | 11821413 |
| 2908 | NR3C1 | 679 | NP_001019265.1 | in vivo | 12093808 |
| 5906 | RAP1A | 1545 | NP_002875.1 | in vivo | 15207703 |
| 6310 | ATXN1 | 3333 | NP_000323.2 | yeast 2-hybrid | 16713569 |
| 161582 | DYX1C1 | 10568 | NP_570722.2 | in vivo | 15189447 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Antigen processing and presentation | hsa04612 |
| Endocytosis | hsa04144 |
| Epstein-Barr virus infection | hsa05169 |
| Estrogen signaling pathway | hsa04915 |
| Influenza A | hsa05164 |
| Legionellosis | hsa05134 |
| Longevity regulating pathway - multiple species | hsa04213 |
| MAPK signaling pathway | hsa04010 |
| Measles | hsa05162 |
| Prion diseases | hsa05020 |
| Protein processing in endoplasmic reticulum | hsa04141 |
| Spliceosome | hsa03040 |
| Toxoplasmosis | hsa05145 |
Structure Information
No matching records could be found.
Domain Information
No matching records could be found.
Ontology Information
| HPRD ID | 4048 |
|---|---|
| Molecular Class | Chaperone |
| Molecular Function | Cysteine-type peptidase activity (GO:0008234) |
| Biological Process | Apoptosis (GO:0006915) |
Drug Information
No matching records could be found.