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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
HSPA5 3309 Heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)  9BIP; MIF2; GRP78 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22996014   2012Cell line : -

Source : Xiangya hospitals of Central South University, Changsha, China.

Sample Type : -

No. of Sample : -

Stage : -

2D DIGE, MALDI-TOF/TOF MSDown-regulation--

23456958   2013Cell line : -

Source : Royal Liverpool University Hospital, UK, Clatterbridge Centre for Oncology NHS Foundation Trust, Wirral, UK

Sample Type : CRC tumor and control tissue

No. of Sample : 396

Stage : TNM Stag II

Immunohistochemistry, Tissue microarraysUp-regulation-The expression of GRP78 is an independent marker of survival in CRC and may be especially useful in identifying a poor prognostic group in stage II disease.

GRP78 expression provides a biomarker that predicts (and determines) response to fluoropyrimidine-based adjuvant chemotherapy.

GRP78 expression was significantly elevated in cancer tissue (p < 0.0001), and correlated with depth of invasion (p = 0.029) and stage (p = 0.032).


Gene Details



Chromosome: 9; NC_000009.11 (127997127..128003666, complement)

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Gene Type protein coding
Gene Family Heat shock proteins / HSP70
Description The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]  
Chromosome 9
Location 9q33.3
Start 125234848  
End 125241387  
Strand -  
Gene Sequence

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Length 6540  
OMIM ID 138120   
HGNC ID HGNC:5238   
Unigene ID Hs.743241   
Ensembl ID ENSG00000044574   
PharmGKB ID -   

mRNA Information


mRNA ID NM_005347.4
Exon join(1..383,481..712,1079..1216,1855..1967,2057..2447, 2561..2798,3080..3247,4234..6540)  
mRNA Sequence

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Length 3973  



CDS Information


   
Locationjoin(262..383,481..712,1079..1216,1855..1967,2057..2447, 2561..2798,3080..3247,4234..4796)
CDS Sequence

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CCDS ID CCDS6863.1



Protein Information


      
Protein IDNP_005338.1
Protein NameHeat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Molecular Wt. (Da)70479
Protein Sequence

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Length 654  
Uniprot IDP55210
Ensembl Protein ID ENSP00000298701  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation466
KAcetylation268
TPhosphorylation518

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2A2M72NP_000005.2in vivo12194978   
338APOB133NP_000375.2in vitro;in vivo12397072   
3507IGHM912CAA34971.1in vivo3122216   
9564BCAR14248NP_055382.2yeast 2-hybrid16169070   
10197PSME35500NP_789839.1yeast 2-hybrid16169070   
56896DPYSL510522NP_064519.2yeast 2-hybrid16169070   
57062DDX245860NP_065147.1yeast 2-hybrid16169070   
80021TMEM628669NP_079232.3yeast 2-hybrid16169070   


Pathway Information


                              
Pathway Name Pathway ID
Antigen processing and presentation hsa04612
Prion diseases hsa05020
Protein export hsa03060
Protein processing in endoplasmic reticulum hsa04141
Thyroid hormone synthesis hsa04918


Structure Information


PDB ID1B0F
Resolution3
MethodX-RAY DIFFRACTION
Chains A  
Molecule PROTEIN (ELASTASE)  
Model View



Domain Information




ID Location Description
cd1024128-403  HSPA5-like_NBD
cl1703728-403  NBD_sugar-kinase_HSP70_actin superfamily
cd1023331-406  HSPA1-2_6-8-like_NBD
cd1023428-405  HSPA9-Ssq1-like_NBD
cd1017031-403  HSP70_NBD
cd1173328-405  HSPA9-like_NBD
cd1173429-405  Ssq1_like_NBD
cd1022829-406  HSPA4_like_NDB
cd1023531-403  HscC_like_NBD
cd1023629-402  HscA_like_NBD
cd1023829-403  HSPA14-like_NBD
cd1023730-407  HSPA13-like_NBD
cd1023031-402  HYOU1-like_NBD
cd1023229-402  ScSsz1p_like_NBD
cd1173729-406  HSPA4_NBD
cd1173929-406  HSPH1_NBD
cd1173232-402  HSP105-110_like_NBD
cd1173829-406  HSPA4L_NBD
cd1023131-403  YegD_like
cd1022930-399  HSPA12_like_NBD
cd1022531-399  MreB_like
cd00012120-248  NBD_sugar-kinase_HSP70_actin
cd07809320-420  FGGY_D-XK_1
cd10227197-397  ParM_like
pfam01968147-245  Hydantoinase_A
cl00668147-245  Hydantoinase_A superfamily
pfam0001230-635  HSP70
PTZ0000931-639  PTZ00009
PRK0029028-653  dnaK
TIGR0235030-635  prok_dnaK
COG044329-637  DnaK
PTZ0040028-652  PTZ00400
PRK1341128-649  PRK13411
CHL0009428-648  dnaK
PRK1341028-614  PRK13410
PLN0318430-650  PLN03184
PTZ0018628-627  PTZ00186
TIGR0199130-633  HscA
PRK0518331-614  hscA
PRK0143319-634  hscA
PRK11678147-374  PRK11678
TIGR0090431-398  mreB
COG4820149-253  EutJ
PRK13930167-399  PRK13930
TIGR02529149-253  EutJ
PRK1392828-271  PRK13928
PRK1392929-270  PRK13929
PRK15080149-253  PRK15080
pfam0672331-398  MreB_Mbl
COG107729-260  MreB
COG0849191-379  FtsA
TIGR01312322-421  XylB
PRK12704536-639  PRK12704
PRK13927169-265  PRK13927
COG1196513-653  Smc
TIGR00414544-627  serS
PRK03918533-626  PRK03918
COG5185514-626  HEC1


Ontology Information


   
HPRD ID3756
Molecular ClassChaperone
Molecular FunctionCysteine-type peptidase activity (GO:0008234)
Biological ProcessApoptosis (GO:0006915)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P11021DB00025Antihemophilic Factor (Recombinant)BiotechDrug
P11021DB00945Acetylsalicylic acidSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO