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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HSPA8 | 3312 | Heat shock 70kDa protein 8 | 11 | LAP1; HSC54; HSC70; HSC71; HSP71; HSP73; NIP71; HSPA10 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20812987 | 2010 | Cell line : - Source : Nanfang Hospital tumour tissue bank. Sample Type : CRC tumor and control tissue No. of Sample : 150 Stage : - | 2-D Gel electrophoresis, and mass spectrometry,Western blot analysis, Immunohistochemist | Down-regulation | - | This gene differentially expressed in between normal colorectal tissue and colorectal cancer tissue experiment done by 2-D Gel eclectrophotesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Heat shock proteins / HSP70 |
| Description | This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] | Chromosome | 11 |
| Location | 11q24.1 |
| Start | 123057492 |
| End | 123062366 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4875 |
| OMIM ID | 600816 |
| HGNC ID | HGNC:5241 |
| Unigene ID | Hs.180414 |
| Ensembl ID | ENSG00000109971 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011542798.1 |
|---|---|
| Exon | join(1..20,1038..1247,1569..1774,2099..2251,2339..2894, 3106..3308,3537..3735,3883..4115,4448..4875) | mRNA Sequence | Download Select all |
| Length | 1872 |
CDS Information
| Location | join(1043..1247,1569..1774,2099..2251,2339..2894, 3106..3308,3537..3600,4539..4633) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS44754.1 |
Protein Information
| Protein ID | NP_006588.1 |
|---|---|
| Protein Name | Heat shock 70kDa protein 8 |
| Molecular Wt. (Da) | 70767 |
| Protein Sequence | Download Select all |
| Length | 646 |
| Uniprot ID | Q14790 |
| Ensembl Protein ID | ENSP00000264274 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 477 |
| S | Phosphorylation | 153;- |
| S | Phosphorylation | 153;- |
| S | Phosphorylation | 637 |
| S | Phosphorylation | 638 |
| S | Phosphorylation | 541 |
| K | Acetylation | 137 |
| K | Acetylation | 137 |
| S | Acetylation | 2 |
| S | Acetylation | 2 |
| Y | Phosphorylation | 611 |
| K | Acetylation | 108 |
| K | Acetylation | 108 |
| K | Acetylation | 348 |
| K | Acetylation | 348 |
| K | Acetylation | 246 |
| K | Acetylation | 246 |
| K | Acetylation | 319 |
| K | Acetylation | 319 |
| K | Acetylation | 589 |
| K | Acetylation | 524 |
| K | Acetylation | 597 |
| K | Acetylation | 512 |
| K | Acetylation | 88 |
| K | Acetylation | 88 |
| K | Acetylation | 601 |
| T | Phosphorylation | 462 |
| T | Phosphorylation | 641 |
| S | Phosphorylation | 254 |
| S | Phosphorylation | 254 |
| S | Phosphorylation | 329 |
| S | Phosphorylation | 329 |
| S | Phosphorylation | 362 |
| S | Phosphorylation | 362 |
| S | Phosphorylation | 385 |
| T | Phosphorylation | 397 |
| S | Phosphorylation | 385 |
| T | Phosphorylation | 397 |
| S | Phosphorylation | 633 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 229 | ALDOB | 1972 | NP_000026.2 | in vivo | 11241348 |
| 338 | APOB | 133 | NP_000375.2 | in vivo | 9694898 |
| 573 | BAG1 | 3292 | NP_004314.4 | in vitro;yeast 2-hybrid | 930 563 111 741 305 |
| 1211 | CLTA | 351 | NP_009027.1 | in vitro | 1975516 |
| 2079 | ERH | 9026 | NP_004441.1 | yeast 2-hybrid | 16169070 |
| 2580 | GAK | 3631 | NP_005246.2 | in vitro;in vivo | 10625686 |
| 2806 | GOT2 | 684 | NP_002071.2 | in vitro;in vivo | 7559589 |
| 3297 | HSF1 | 778 | NP_005517.1 | in vitro;in vivo | 763 972 216 293 251 |
| 3301 | DNAJA1 | 4159 | NP_001530.1 | in vivo | 1 007 592 116 225 870 |
| 3303 | HSPA1A | 774 | NP_005336.3 | in vitro | 930 563 111 741 305 |
| 3320 | HSP90AA1 | 777 | NP_001017963.2 | in vivo | 9269769 |
| 3717 | JAK2 | 993 | NP_004963.1 | in vivo | 11679576 |
| 3925 | STMN1 | 1047 | NP_001138926.1 | in vitro;in vivo | 10197448 |
| 4071 | TM4SF1 | 1854 | NP_055035.1 | yeast 2-hybrid | 16169070 |
| 4435 | CITED1 | 2146 | NP_001138357.1 | in vitro;in vivo | 10722728 |
| 5925 | RB1 | 1574 | NP_000312.2 | in vitro;in vivo | 7673249 |
| 5966 | REL | 1286 | NP_002899.1 | in vitro | 2155506 |
| 6667 | SP1 | 1796 | NP_612482.2 | in vitro | 10976766 |
| 7852 | CXCR4 | 1217 | NP_001008540.1 | in vitro;in vivo | 16365278 |
| 8655 | DYNLL1 | 3334 | NP_003737.1 | in vitro | 14760703 |
| 8841 | HDAC3 | 8950 | NP_003874.2 | in vivo | 12502735 |
| 9531 | BAG3 | 4860 | NP_004272.2 | in vitro;in vivo | 9873016 |
| 9532 | BAG2 | 4859 | NP_004273.1 | in vitro;in vivo;yeast 2-hybrid | 9873016 |
| 10006 | ABI1 | 4336 | NP_005461.2 | in vitro | 15048123 |
| 10072 | DPP3 | 6012 | NP_005691.2 | yeast 2-hybrid | 16169070 |
| 10273 | STUB1 | 6232 | NP_005852.2 | in vitro;in vivo;yeast 2-hybrid | 103 301 921 629 325 000 000 000 |
| 10474 | TADA3 | 4252 | NP_006345.1 | yeast 2-hybrid | 16169070 |
| 10971 | YWHAQ | 886 | NP_006817.1 | in vivo | 15324660 |
| 54205 | CYCS | 479 | NP_061820.1 | in vitro;in vivo | 8663341 |
| 84273 | C4orf14 | 12823 | NP_115689.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Antigen processing and presentation | hsa04612 |
| Endocytosis | hsa04144 |
| Epstein-Barr virus infection | hsa05169 |
| Estrogen signaling pathway | hsa04915 |
| Influenza A | hsa05164 |
| Legionellosis | hsa05134 |
| Longevity regulating pathway - multiple species | hsa04213 |
| MAPK signaling pathway | hsa04010 |
| Measles | hsa05162 |
| Protein processing in endoplasmic reticulum | hsa04141 |
| Spliceosome | hsa03040 |
| Toxoplasmosis | hsa05145 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd10233 | 6-381 | HSPA1-2_6-8-like_NBD |
| cl17037 | 6-381 | NBD_sugar-kinase_HSP70_actin superfamily |
| cd10241 | 4-378 | HSPA5-like_NBD |
| cd10170 | 7-378 | HSP70_NBD |
| cd10234 | 1-380 | HSPA9-Ssq1-like_NBD |
| cd11733 | 3-380 | HSPA9-like_NBD |
| cd11734 | 7-380 | Ssq1_like_NBD |
| cd10228 | 5-381 | HSPA4_like_NDB |
| cd10235 | 7-378 | HscC_like_NBD |
| cd10238 | 6-378 | HSPA14-like_NBD |
| cd10236 | 6-377 | HscA_like_NBD |
| cd10237 | 7-382 | HSPA13-like_NBD |
| cd10230 | 7-378 | HYOU1-like_NBD |
| cd10232 | 5-378 | ScSsz1p_like_NBD |
| cd11739 | 7-381 | HSPH1_NBD |
| cd11737 | 7-381 | HSPA4_NBD |
| cd11732 | 8-378 | HSP105-110_like_NBD |
| cd11738 | 7-381 | HSPA4L_NBD |
| cd10231 | 7-378 | YegD_like |
| cd10229 | 7-374 | HSPA12_like_NBD |
| cd10225 | 7-374 | MreB_like |
| cd00012 | 92-223 | NBD_sugar-kinase_HSP70_actin |
| cd10227 | 171-372 | ParM_like |
| cd07809 | 319-378 | FGGY_D-XK_1 |
| PTZ00009 | 1-613 | PTZ00009 |
| pfam00012 | 6-612 | HSP70 |
| PRK00290 | 1-613 | dnaK |
| TIGR02350 | 6-612 | prok_dnaK |
| COG0443 | 5-613 | DnaK |
| PRK13411 | 4-612 | PRK13411 |
| CHL00094 | 4-613 | dnaK |
| PTZ00400 | 4-613 | PTZ00400 |
| PRK13410 | 4-544 | PRK13410 |
| PLN03184 | 7-577 | PLN03184 |
| PTZ00186 | 3-601 | PTZ00186 |
| PRK05183 | 6-544 | hscA |
| TIGR01991 | 6-570 | HscA |
| PRK01433 | 6-524 | hscA |
| PRK13930 | 141-374 | PRK13930 |
| TIGR00904 | 7-352 | mreB |
| pfam06723 | 7-373 | MreB_Mbl |
| TIGR02529 | 120-255 | EutJ |
| COG4820 | 123-251 | EutJ |
| PRK11678 | 7-351 | PRK11678 |
| PRK13928 | 143-268 | PRK13928 |
| PRK15080 | 123-228 | PRK15080 |
| COG1077 | 7-292 | MreB |
| TIGR01312 | 307-385 | XylB |
| PRK13927 | 143-301 | PRK13927 |
| PRK13929 | 1-240 | PRK13929 |
| COG0849 | 165-375 | FtsA |
| PRK03918 | 497-602 | PRK03918 |
| pfam02463 | 497-602 | SMC_N |
| COG1070 | 307-392 | XylB |
Ontology Information
| HPRD ID | 3458 |
|---|---|
| Molecular Class | Heat shock protein |
| Molecular Function | Cysteine-type peptidase activity (GO:0008234) |
| Biological Process | Apoptosis (GO:0006915) |
Drug Information
No matching records could be found.