CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
HSPD1	3329	Heat shock 60kDa protein 1 (chaperonin)	2	HLD4; CPN60; GROEL; HSP60; HSP65; SPG13; HSP-60; HuCHA60

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
20089989	2010	Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : - No. of Sample : - Stage : -	Biochemical isolation to nano-LC-MS/MS analysis	Up-regulation	11,9	-
21304002	2011	Cell line : - Source : GenBank and Oncomine Sample Type : - No. of Sample : - Stage : -	Meta-analysis and RT-PCR	Up-regulation	-	Publicly available data used, meta-analyzed leading to 34 candidate marker genes of CRC. Multiple case-matched normal and tumor tissues were examined by RT-PCR for differential expression, and 9 genes were validated as CRC biomarkers.
21973086	2011	Cell line : - Source : Academic hospitals in Lyon, Dijon and Saint-Etienne (France), Etablissement Fran?ais du Sang, the French blood bank Sample Type : CRC tumor, serum and control tissue and werum No. of Sample : 23 colonic adenocarcinoma and matching normal mucosa patients, serum from 152 patients diagnosed with CRC and 130 healthy volunteers Stage : -	2D-DIGE, MALDI-TOF MS, western blotting, immunohistochemistry, tissue microarray, ELISA	Up-regulation	-	Serum HSP60 appeared to be more specific for late-stage CRC. Combination of serum markers improved clinical performance: the AUC of a three-marker logistic regression model combining HSP60, carcinoembryonic antigen and carbohydrate antigen 19-9 reached 0.77.

Gene Details

Chromosome: 2; NC_000002.11 (198351308..198364998, complement)
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Gene Type	protein coding
Gene Family	Heat Shock Proteins / Chaperonins
Description	This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]
Chromosome	2
Location	2q33.1
Start	197486584
End	197500274
Strand	-
Gene Sequence	>gi\|568815596:c197500274-197486584 Homo sapiens chromosome 2, GRCh38.p2 Primary Assembly GCCCCGACGCGCACCGCGATTCGCCCCAAGGGCCCTGCGCAGGACGCTGACGCGAAGACTCGGAGGCGGA AGAAAAAAGGAGCTGTTTCTAGGCTTTTCTAGGCGCCCAGCCGAGGTGAAAGAACTACCCCTTCGTCCCC TCCCGGAAATGACGCGATTTGACCCTTGAGCCGTAGGGAGCGCGGCATTTTCTGGAAAGTTCTGGAACCG AGCGAGGCCCGGGAACTAGACTAAGCCGGCCGGAGAGGGCTGAGCGCGCTAGCACACCCTGCGCGGGTAG GGAGGGGCGGGGCTCGCGCGCAGGGTGTGCAGATTGCAGGGCCCGGGCTGACGGGAAGTGGGTGGGAGCT GCCTGCACACGCGGTGCCGCGGGGCGGGAGTAGAGGCGGAGGGAGGGGACACGGGCTCATTGCGGTGTGC GCCCTGCACTCTGTCCCTCACTCGCCGCCGACGACCTGTCTCGCCGAGCGCACGCCTTGCCGCCGCCCCG CAGGTACGCGGCCTTCCCGCACCACCTCCCCCCGGCTCCTGCGACCCCCGAGTGGGCCTTCCTCCTCTGC GGTCCAGCTGGAGGGTGCGGGCGGCGACAACCTGGAGTTCCGCACCGCGCCGCACCGCAGGCCCAGGCCT GCGGGTCCAGGCCTCGCGGGTCCATGCGGGTTCCATCACGTGCGACGCGGATCCTGGACCTCGGCTGGGC GCGGGAGGGACAACTCGTGGGGTTTGAATTTGGGGGATTGTAACCACTTAGGCCCGCTGGTGCAACCTGC GCCTGGCCGACTTCAGGGAACCGGGGAGGGTGGTGTACGTGAGGGAACCGCTTTTTTCCCCCGCAGGCAG CTGGGATACCGCGCCTCCAGTCTTGACCTTGCTGGGGGCGTTCGGAAAGAAGGACACGTGGGCTCGCGCC GAGTGGGCCGGGCCGCCGCCCCCAGCATCGCGGCCTTGCTGGTTGCTCTGATACAGTAGCCTTGGGTGGA TCCATGGAGACACTTTGCTGAGCGGCTTTTTGCACCGTCAGGAATACTTTTAACTTCCCTGGTCACTTGG ATTTGTAACTTGCCTCTCTCCGGCTGACTTGGTTTCTCAGGGGCCACAGTTGGAGTGGGTCTGCCCACAA GGCCGTTTTCGCGGTGAAAGATTAACTCGTTTTTGGCGGCAGGGATAGGTGGCCGTGGGGAAGGAGCCGC ATGTGCTTTGTGCTGGTGCTATAGGTCAGGCGCCGGCCGGGGCGGCCTCTTTAGCTTGCGCTAGTGGCTG ATGTTCCGAAGCTGCGGCGCCTTCCGTCATTCAGGCGTAGTGGCTGGCGGAGGTCAGCCAGGCTCAGCAT CTCACGTTGCTTGCTCTGTTGCACAGGTGGGCATGTTTGTTCTGCAGCGCACCACGGGTGGTAGTTCTGA TGATCTTTTTGCTTCCATCCCCAGAAATGCTTCGGTTACCCACAGTCTTTCGCCAGATGAGACCGGTGTC CAGGGTACTGGCTCCTCATCTCACTCGGGCTTATGCCAAAGATGTAAAATTTGGTGCAGATGCCCGAGCC TTAATGCTTCAAGGTGTAGACCTTTTAGCCGATGCTGTGGCCGTTACAATGGGGCCAAAGGTACCAGTAT TTTTATTTTATTGTAATTACGGTATTATTAATAGCATTTTACTCACAAATAGTCGCACTGAACTATTCAA CAGTACTTTCATCTCCATTTTTGAGAGAACTCAGTTTACATGTAAGAATTCTGAAGTATTGGTTAGCCTT TTTTTCTTAGACATGATCTTAAAGCTTAAACTGCTTCAGCCAGATTTTCGAAACTATTTTGTTCAATGTG TGATGTAATCAGGTAGTAACTTACAGCTCAAGGTGGATTCTTAAACTCGAGGTAGAATTTCGCTGGCTTA AGTTAAAATTTGGATCCTTTCCCAGTAGTTCATGCCAAGTGTAGAGAGAAGAGTTTAACTTATCTTCCAT AATTCCTTAGGTATGTGCTTGTAGATGCTAAATTTTTTTTTGGTTTATTGTAGTAAAATGTACACAACAT AAAATTACCATTAAGTGTGCACTTTGGGGACATCAATTACATTTATGTTGTGCAGTCATCACCACCATCC ATCTCCAAAACTTTTTATATGGAAAAATTGTAACTTTGTACTCATTAGACAGTAGCTTCCCATTCTCTCC TCCACCCCAAGATGCTAGTTTTACCCATCGGTTTTCTGCTGTTCTCTTGTTCCAAAGCATATTTAAAATA AGTCTCATTTAATAGGGGTAATGTTTTGAGGAGGCCTTTGAAGGTGGTGTGCAGTCAAGTGGTGCTTCAT TTCAGTTTGAAGACAGTTCAGATATCAAGTGATCCAACAACTGCCTAAAATACAACATTTGCACACCTCA CAAATAGAAAGTAGCAGCTTTAGTTCAAATCCAAAGGATGGCCAATAATTGTGCCATGGTTGAAGTTTTA TGTTGCGTGAACCTGGAAGAGCACGCTACTTGCCTTGATGGTTAATATTTTAGTTAAACGGATTTTAAAA CAAGTCACATTACTTTAAAAGATAACAGGCACTAACTAAAGTATAAGTGATAGGAAGATTGTTTTATTCT TTGTCTTGTGTTCTTGTTCATTTTATAAGATGACAAGTTTTAGTCCCTAGGATTTTAATCTCCTAAATTA CCTAGTTCAAAATTATGCTCTTGGCAGAGAATCAGGTCATTTTGTCTGTAGACAAAGAATGTCGATAAAC TTGCCCTTGAGGTTCATGCTGCAAGACTGATAAAAATGACACAACTTACGTTGAGACTTTGAAGTAGTTG CTTTATTATGAAGACTGCTCATTTTTAAAAATGTAAATCATCCTTAGGGTATGTCTGATCCTGTTACATT TTTTTCTTCTAGGGAAGAACAGTGATTATTGAGCAGAGTTGGGGAAGTCCCAAAGTAACAAAAGATGGTG TGACTGTTGCAAAGTCAATTGACTTAAAAGATAAATACAAAAACATTGGAGCTAAACTTGTTCAAGATGT TGCCAATAACACAAATGAAGAAGCTGGGGATGGCACTACCACTGCTACTGTACTGGCACGCTCTATAGCC AAGGAAGGCTTCGAGAAGATTAGCAAAGGTGCTAATCCAGTGGAAATCAGGAGAGGTAGGAATGTCTGTT GTCACCACAGTGTTCTAAACTTCAGTGTGCTTTAAGGCATTGATTCCTTGGACCTAAGGAAAGTGTTAAC TTGAGGAAATTAATCCTTCTCTCATTCCTCCTCTTGGCCTGGAGAAATCTTAAACTGGGTTTTCCTTTAG CAAGCTTGGCTGTATGGTGGGTAGGTACTGTTAGGTAATTTTGATATTTTACTTAGTTGGTTTCTTTTGT TTTTAGAGACAGGGTCTTGCTCTGTAGCCCAGGCTGGACTGCACTGGAACTCCTGGGCTCAAGCAATCCT CCTGCCTCAGCCTCCAAGTAGCTGGGACTACTACAGGCACTCACCACCATTCCTGGCTAATTTTTAGTTT AGTTTTGTAGAAAGTAAGACTAAATACACTGGATCATTCAGAATGTCAGAAAGTAATGTTTTCCTCAGTT TATTTTTTCTTAATAGCACACACCATGTTATTGGTTTGTGTTTTGTTAGTGCTTGTAACTAGAGTGCAAC TTAATTAACAATTTGCTCCTCCTCATGAGGTTCATGGCAGTATAGACTTAAATTCTAGTCCCATGTTTGT CATTTATTAGCTGTGTGCTAAGACTTGGTTTTCCTATCAGCAGAATTGCTATGTATATCTAGGGTATGTT AGGGTTCAAACCAGGAACCCTCTTGTAAGTGAAGGTGGGGGGAGCTATTGGTAATTTTTTGTCAGAATTG GCATACTAATTTATTACTACATTACTAATGTATCATTACCTCATCTATTTCAGTGTTTATGGGCCAAGTG AATATACTTCACTAAAAGCAGTTTTACTGTAAATCACTAACAAGTATTAATTAAGGTTATGAAGAGGACT TACCAGCACCTTGCATTGGATTTTTTTTGAAGTAACAGTTCTCAAACAAGAGAGCTAGCACTATTCCCAA TTGAGCAAAATGGGACTATTAAGACTGATGTAAAACAAAAATATTTTGTTAGTTCATAATACGTACTAAA TTGAGGGGATTTCAGATAATTGACACCTGCAGAGGCATAGTCACAACAGATTCCTATCATTTAAGAACTG TACTTCTTGTTGAAAATAAGGGAGTGTTAGCCATTTTGGTCCTTTTTTGCATCATCTAATGGACATGAGA AGTGTCGTGGACCCTATTGGAAACAGCATGATTGGGTTAGGAATTTGCATAGGATGAGTTCAGTGGTGAG ACTTTTGAAACTACACACATCTACCTTGTTTTAGTCCTATTTTCAAAATTTTGGCATTGTGAGATTTTAT TTACTGTGTGAACCTAAAGTTACTGTTTAAGTACATGCCACGCAACTCTGTGTTATTAAGAAGCACTGTC TCAGAAGCTGTGTGTAAATTTAATATTAAGGCACTAAAGACCAAGCATAGGTACATGCCTGTAGTCCCAG CTACATGGGAAGCTGAGGTGGGAGGATTGCTTGAGCCCAGGAGTTCAAGACCACCTTGGGCAACATAGTG AGACCTTGTCTACAAAAATAAAAGAAGCTGAGCATGGTGGCTTGAGCCTGTGGTCTCAGCTACTCCCTTG AGCCCAGGATGTCAGGGCTGCAGTGAGCCATGATCTGTGCTACTGCACTCTAGCCTGGGCAGCAGAACAA GACCCTGTCTCAAAAAAAAAAAAAATTTTTTTTTTTAAGTTAAGGCATTAAAATATTTGTCACAAATCTC AAGATTTCTACTTGACATAGAAGCCATGAGAGAAATAAACATTGTAATGACATATATCGTTGAACTAGGT GTGATGTTAGCTGTTGATGCTGTAATTGCTGAACTTAAAAAGCAGTCTAAACCTGTGACCACCCCTGAAG AAATTGCACAGGTAAGGACTTAACATGTTACACGTTTTTTAAAAAAAATTTAATGGCATGTGTGATTTTT TTTTTCCCTTGATCACACCAATGTCAGAATAACAATACTACCCAATCATCAATATTAGAATCATTGTTTC TTACTGCTAAAACCTTTGAAAAGAATTATGACCATAATGGTTGTCATTTAGTTCTACATGTGGTTGTCAT TTTAGTTCTACATGGCTGTAAAATGGATTCATATGATTGTGAAAATGTTCTTAGCCATTGTCAAAGGTGC ATAAGTTTTGTCAGTTTGTAATGAAGTCAGCATTTTTAAACTTTTTGTTACAAGAATAGTTTTATGTATC ATATTCTTCAAAACAATGTAGTCAAATAATGAATCGGAAAAGAGCAAAGAACCAGTACTTCATGAAAACT ACCATAACGTAAATTCCCCTTCTCTCCCCTGGATGGAAGTATCAATTTGGAAGTTACTAGGAAAAGGTAA GGGAACTGACTGAGGACACTAGGCTTACCTTTTAATTTCGAAGAGTAACTGGATTATTTCAGGTTGCTAC GATTTCTGCAAACGGAGACAAAGAAATTGGCAATATCATCTCTGATGCAATGAAAAAAGTTGGAAGAAAG GGTGTCATCACAGTAAAGGCAAGTGTGTTTGTATTTTTAAAGATAATTTTGAGTTATCTTATGATCAAAA GTTTGAGTTATCTGATGATCAAAACTGAATTTTTCAAACAGAAAAATTCTGTTTTAAAAACTGCTTTTTT TATTCCTTCATATGTAGTCTCAGCACATGTATAGAATAAAGTACTTACTGTGTTTTATGTGAATTAGCCT TTGCTGCATGAAATGAATCCATCCTAACTTAAATGATTATTCAAATAAGCACTTTTGGGATTTTTTGCAG AAGTGTAATTGGATGTCCTGGGCTGTTTCATACTCTACCCTGCATCTCTTATGGCCAGAGGGGTCTGTTT TTATTAATCTGGCCTGTAATTCCATGTTTTGTGTTCAATGAAATCCATATACCTAATTCTTTGACTTTTC ATAGGATGGAAAAACACTGAATGATGAATTAGAAATTATTGAAGGCATGAAGTTTGATCGAGGCTATATT TCTCCATACTTTATTAATACATCAAAAGGTAAGAACAAATCAATAACTGAATTATTATTATTTTTATTAT TTTAGACAGAGTCTCATTCTCTGTTGCCCCGGCTGGAGTGCAGTGGCATGATGTGGTGGCGCGTTGCTCA CTGCAACCTCCGCCTTCCGGGTTCAAGTGATTCTCTTGCCTCAGTCTCCCAAGTAGCTGGGATTACAGTC ACACGCCACCATGCCAGGCTGATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTG GTCTCTTAACTCCTGACCTCAGGTGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGATTATAGGTATGA GGCTCTGTGCCTGGCCAATTTTTGAATTTTTTAATAGAGACAAGGTTTAGCCATGTTGGCCAGGCTGGTT TTGAATTCCTGGCCTCAAGTCATCTGCCTGCTTTGGCCTCCTGAAGTTTTTAAAATATACTTTCTAATAT GTGTCAAACTATAGGTATTAGTTGGTGTCATCCTCTAAAAAATAAATGTATATATTCCAAAAGTTAATGC ATATGAGAAATGAAGGAGGAAAACCAACTCACTGGTGAATTTTAAAGTGTATTGGAACCTTGGTTTCGCT TTTCATTTAAATGTATTGCAGTCATTTTTTGTATATTTTTGAAATCTTCATTATTTTTACAGGTCAGAAA TGTGAATTCCAGGATGCCTATGTTCTGTTGAGTGAAAAGAAAATTTCTAGTATCCAGTCCATTGTACCTG CTCTTGAAATTGCCAATGCTCACCGTAAGCCTTTGGTCATAATCGCTGAAGATGTTGATGGAGAAGCTCT AAGTACACTCGTCTTGAATAGGTAATAAGCAGTGGTATTTGTTGATTTATATTTCTCGGTGAAAGACAGA ATTATTTGTATTGCTGTTTGCAGTTTCCATCATGTGTACCTCCACATTTGATCCAGTTGGGTTTGTATCT AGAATTGTAATTGTGTAAATCAGGTGTGCTCTAATGTATCCTTATGGTTGTGTTTTTGAAGGAACCCCAA AGTCTTTACTATTTTGATCAGCTTTCTCATAGAATAGACTAATTTAGCACATGGGTACCTTTCTGTATTT TGCAAGTGTTTACAGTTGTTTTGAAGGCACATGACTGAATCTTGTATTTTTTTTTTTTGAGACAGAGTCT CACTCCCTGGCCCAGGCTGGAGTGCAGTGGCATAATCTTGGCTCACTGCAATCTCCATCTCCTAGGTTCA AACAGTTCTGCCTCAGCCTCCCAAGCAGCTGGGACTACAGGTGCGTGCCACCACACCTGACTAATTTTTG TATTTTTAGTAGAGACAGGGTTTCACCATATTGGCCAGGCTGGTCTCAAACTCCTGACCTCGTGATCCGC CCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCGCCCGGCCTTGTAATTTTTTTAT TTTTTATTTTTATTTTTGGAGACAGAGTCTCTGTCACCCAGGCTGGAGTGCAGTAGTGCAGTGGCTCAAT CTCAGCTCAAGCCTCCGGGGTTCAAGTGTCAATCTTGTTTTTTGTTTTGTTTTGTTTTGTTTTTTTAAGG TTTTTCTGGTTAAAAATATGTAAATTTTCAGAATATTATTTTGCATAGAACAGGGAAGTAAACAACTAAC TTCCAAATAACTCAGAGCCAGGCATGGTGGCTCACAGCTATAATCCCAGCACTTGGGGAGGCACAGGCGG GTGGATCACCTGAGATCAGGAGTTCCAGACCAGCCTGGCCAACATAGTGAAACCCCGTCTCTACTAAAAA TATAAAAATTAGCAGAGCATGGTGGCGTGTGCCTGTAATCCCAGCTACTCAGAGGCTGAGGCAGGAGAAT CACTTGAATCTGGGAGGCGGAAGTTGCAGTGATCCGAGATTGTGCTGCTGCACCCCAGCCTGGGCAACAA AGCGAGACTCTGTCTCTAAATAAATAACTCAGATGTAAGTGTATTTCACCATCGAATATTTTTATTTATT TTGAGAGACAGACTCTGTCACCCAGGCTGGCCTGCGGCGGCACGATCATAGCTCACTGCAGCCTTGAACT CTTGGGGTCAAGCAATCCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACACACTTGCACAAGCACACT TGGCTGATCTTTTAATTTTTTTGTAGAGACGAGGTCTCAATATGTTGCCTCAATATGTTGCCTAGGCTAG TCTTAAACTGTTGGTGAATCTTAAGTGATTCTCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCAT GAGCCACTACCCTTGGCTGTGATCAAGTATTTAGTCTGTTGTTAAATGTTTACTAAATAGTCTGAAGTAG AGAAAATAGCACCCAATCTAAAATAAGGTGAGGTCTAGTCACTTATTTAAATCTACATTTTAAGCTATAG TTTACTATTAGTTTAAACTTTAAGACAGGTAATGTTCATGCTGCAGACAATCTAAGGGCATTATTAAAAT GTTTGTTCTTCCTTATCTCAGAATTGAAGTATGTCAGAAGCAAGACTTTTCTTTCCATTTTGTTATAGTA GAAATGCATACATTAACAGGTACGTTTTAGACATTACACGTGCTCATCTGACCCAAAAGCTCTAATGAGC TGCCTTACCCTGGAATGTTTTTCTTAGCTTGGATTTGCTTTTTTGGAGGGATTAAGAAAAGACTTGGCTG GGCGTGGTGACTCATGCCTGTAATCCCAGCAGTTTGGGAAGCCGAGGCGGGTGGATCATGAGGTCAGGAG ATGGAGACCATCCTGGCTAATACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTG GTGGCGGGCTGAGGCAGGAGAATGGCGTAAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATCTCGCCA CTGCACTCCAGCCTGGGCGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAACACACAAAAAAAAGAC TTGAGGCCAGAAAAAAACAAGCCTACAGAGTTTTCATTAAGCCATTTTACTGCTAGTTGAAAAGTGGGAT ATCCAGTTTACATAGCATATAGCTTATTCCTCTGATTTTTATTTGGGTCCTTAATAAAATAGACCAGCTG TCTTGAAGTTTGAACGTTGCTTCTGTTTCACAATCTGCTCTCAAATGGACATTTGATTACACATTCCAAG TATTCATTTACCTGGTAAAAATTTCAGGTGAGCTTAACAATACTGTCAGCTTTTTGTATAACATTTATAA AAGAAGTGAATTCAGAACATTGCTCATTCAAAACTCAGCATTAATATATGGAGATGTTTATTAAATGACC CTCAAATGTAATATTTAGTAATTACTGTTTTTCTACCATTCATAATAGTTATCACTGTATCCTATAACTT ACTGTGATGTGATTTTTGCTGCTCGGCCTCCTGAGTAGTGGGGATTACAGGTGCCTGCTACCACATTTGG CTGATTTTTGTTATTTTCAGTAGAGACAGGGTTTCACCATCTTGGCCAGGCTGGTCTCGAACTCCTGACC TCGTGATCCACCTGCCTGGGCCTTGCAAAGTGCCGGGATTACAGGCCTGAGTCACCACGCCCGGCCAGGC CAACAGTTTATTAAGAAGGTAAACGGATATGGACAAGTATAATTAATAGAAAATAGCCTAAACTGTCTCA GATACTTCCTGTCTTAATTTGATCAAAAATTGCTAGGAAGCAAAAAAAAAACAAAAAAACACAAAAACCA AACCAGATTACTTAGGGAGTCCTAAGTAATCTAGTAACAGCTTGAGGGGAATTAAACAGATAGGCATTTT TATTTCATTTAAATCTTACTATCAACTATTCTTAACAGGCTAAAGGTTGGTCTTCAGGTTGTGGCAGTCA AGGCTCCAGGGTTTGGTGACAATAGAAAGAACCAGCTTAAAGATATGGCTATTGCTACTGGTGGTGCAGT AAGTAAAATAAATGTGATAATGGTTTGCTGAATGTTTATACTTGTCTGGAATTTATAGATAGTTTAACAT TTCACAATTAGATACTACAACTATCTGTTTCTTTTGGCTCTTTGGAAGGTAGGGGTTGGATTAAATTCCC GTTAATTTGCCACAAGTCTGGCCTAAGAATGAGCTTACTGACTATTCTATATTGACTAAATCTTATTGAC TGAATAAGGGGGTTTCCTTTTTTTTGTTTTTTTTGGAGACAGTGTCTTGATCTGTCTTGACTATTCTTGA CTTGATCTATATTGACTATTCTTATTGACTTAAATCTGTGGGGTTTCTTTTTTTTTTTGAGACAGGGTGT CTTGATCTGTCACCCAGGCTGGAATGCAGTGGCACGATCTTGGCTTACTGCAACCTCCACCTTCTGGGTT CAAGCAATCCTCCCGTCTCAGCCTCCCAAGTAGCTGGGACTACAGGTGCAGTACCATGCCCAGCTAATTT TTTTACTTTTAGTAATGACGGGTCTCACTGTATTGCCTAGGCTTCTCAAACTTCTGGACTCAAGCAATAT GCCTGCCTCCGCCTCCCAAAGTCCTGGGATTACAGGCATGAGCTACCGAGCTCAGTTTTGAAAGGTAGAA GTGTATGCTACAAGGGATGTAGGACTTGAGAGTCAAGGCCTATGGTCTTGTCCTGGCTCTACCAGTAAGT GTGACCTTCGATGTTTTTTTCTCAAGTAAGGCTGGTAATAATTACCACAGTTGTGAGAATTGAGAATTTG GAAATGCAGTGAAAGAGACTATACTCAAGTCTTGTTCTGGACTAACAGTGATCTTAAAATCTCTCATTTC AAAGAAATAAAGTATTTTGATGATTCTCTTGCATGGTGTATTAATAAACTTGGTATAATGGCAGAAACTG TAACCTACAACAGGTTTACGTTTAACTCTTTTTGTAGGTGTTTGGAGAAGAGGGATTGACCCTGAATCTT GAAGACGTTCAGCCTCATGACTTAGGAAAAGTTGGAGAGGTCATTGTGACCAAAGACGATGCCATGCTCT TAAAAGGAAAAGGTGACAAGGCTCAAATTGAAAAACGTATTCAAGAAATCATTGAGCAGTTAGATGTCAC AACTAGTGAATATGAAAAGGAAAAACTGAATGAACGGCTTGCAAAACTTTCAGATGGAGTGGCTGTGCTG AAGGTAACATTCATTATTATGAATAAGTTTCTTGGGTTCTGAGTCCAAGAATGATTTTGCTTCTGTAGTA TTCCCCAGTAGTACCATAGAACTAAACGAATACTTGAGGAATTAACTTCATAGTGGAATTTTGTTTGTTT TGTTTTGAGCTCTTCGTCACCCAGGCTGGGATGCAGTGGTGCGATCTCGGCGCACTGCAACCTCCGCCTC TTGGGTTCAAGCGAATCTCCTGCCTTGGCCTCCCGAGTAGCTGGGATTACAGGCACTTGCCACCATGCCT GGCTAATTTTGTATTTTTAGTGGAGACAGGGCTTCACCATGTTGGTCAGGCTGGTCTCAAACTCCTGACC TCAAGTGATCCACTCACCTCAGCCTCCCAAAGTGCTAGGATTACAGGTGTGAGCCACCACGCCCACCTCA GGATTGCTTTTTAAGTAAACTGCTTTTAAATGACTTGGCAATTAGCATCTTGAATGAAGAGGCCATACTA ACTGGAATTCTTTTCGTCTTTAGGTTGGTGGGACAAGTGATGTTGAAGTGAATGAAAAGAAAGACAGAGT TACAGATGCCCTTAATGCTACAAGAGCTGCTGTTGAAGAAGGCATTGTTTTGGGAGGGGGTTGTGCCCTC CTTCGATGCATTCCAGCCTTGGACTCATTGACTCCAGCTAATGAAGATCAAAAAATTGGTAAAAAGTTAC CTTTTAAATGAGTTTGTGGCCTGATTTTAGTTTTTCTTAGAATAATAATGTTGCAGTCCCCTAAATGGAA TAGCACATTCATTTCCTGAATAACAGAAGTAGAATAGTGCTAATGTCAGAGCTAAACATGCATCACATCT TTTTCAGAGGAAATGATTTGATCTGTAGTAGGATTGGGATTTCCCTACATCAATATCCTCACAACTTATA AATGTGTTACAATATTTACAAATGAAAGTATTAAAATTTTGCTGAAATTTCTCTGTAGGTATAGAAATTA TTAAAAGAACACTCAAAATTCCAGCAATGACCATTGCTAAGAATGCAGGTGTTGAAGGATCTTTGATAGT TGAGAAAATTATGCAAAGTTCCTCAGAAGTTGGTTATGATGCTATGGCTGGAGATTTTGTGAATATGGTG GAAAAAGGAATCATTGACCCAACAAAGGTAAATGGTTGAACACTTTCTAAAAATTCTTTTGTTGTTCATT TTGTTAATGTATCCTCACATCCCAAATCTTTGATTTTGTCACCAGAAAAATAGTCTAATAGCAGTAGCAA CAGCAATAGCTCTTGTGCCCATCAACAATTCTCATGTACATTTCCAGCACCTAGATATTTAATACTCCAC TAAAAGGAAGCAGGATCCCTTGAGTAGCAGTTGAGTCCATGCCTGGAGGCAGGAAAAAATCAGGATGGAT CTGGAACACCCTGTTCCTGCCTGGCAGTAAGAATACTTTCCAAGATACGCAGAACAGGGTTTTGTTTTGT TTTGAAGACAGAGTCGCTGTGTCGCCCAGGCTGGAGTGCAGGCAGTGACAACCTCCACCTCCTGGGTTCA AGCGATTCTCCTGCCTCAGGCTCCTGAGTAGCTGGGATTACAGGCATGCACCACCATGCCTGGCTAATTT TTGTATTTTTAGTAGAGACGGGGTCTCATCATGTTGGCCAGGCTGGTCTTGAACTCCTAACCTCAAGTCA TCTACCTGCCTCAGCCTCCCAAAGTGCTGGATTACAGGTGTGAGCCACCATGCCCAGACAGAAATTTTCA ATAAGTCTTGCTCATATTTTACTAAGGGAAAACTAATTAATTAAATTTTTTTCTAGGTTGTGAGAACTGC TTTATTGGATGCTGCTGGTGTGGCCTCTCTGTTAACTACAGCAGAAGTTGTAGTCACAGAAATTCCTAAA GAAGAGAAGGACCCTGGAATGGGTGCAATGGGTGGAATGGGAGGTGGTATGGGAGGTGGCATGTTCTAAC TCCTAGACTAGTGCTTTACCTTTATTAATGAACTGTGACAGGAAGCCCAAGGCAGTGTTCCTCACCAATA ACTTCAGAGAAGTCAGTTGGAGAAAATGAAGAAAAAGGCTGGCTGAAAATCACTATAACCATCAGTTACT GGTTTCAGTTGACAAAATATATAATGGTTTACTGCTGTCATTGTCCATGCCTACAGATAATTTATTTTGT ATTTTTGAATAAAAAACATTTGTACATTCCTGATACTGGGTACAAGAGCCATGTACCAGTGTACTGCTTT CAACTTAAATCACTGAGGCATTTTTACTACTATTCTGTTAAAATCAGGATTTTAGTGCTTGCCACCACCA GATGAGAAGTTAAGCAGCCTTTCTGTGGAGAGTGAGAATAATTGTGTACAAAGTAGAGAAGTATCCAATT ATGTGACAACCTTTGTGTAATAAAAATTTGTTTAAAGTTAA Download Select all
Length	13691
OMIM ID	118190
HGNC ID	HGNC:5261
Unigene ID	Hs.595053
Ensembl ID	ENSG00000144381
PharmGKB ID	-

mRNA Information

mRNA ID	NM_199440.1
Exon	join(1..115,1425..1600,2883..3135,4899..4981,5523..5618, 6025..6118,6783..6951,9979..10078,11028..11273, 11784..11958,12239..12417,13077..13691)
mRNA Sequence	>3329 GCCCCGACGCGCACCGCGATTCGCCCCAAGGGCCCTGCGCAGGACGCTGACGCGAAGACTCGGA GGCGGAAGAAAAAAGGAGCTGTTTCTAGGCTTTTCTAGGCGCCCAGCCGAGAAATGCTTCGGTT ACCCACAGTCTTTCGCCAGATGAGACCGGTGTCCAGGGTACTGGCTCCTCATCTCACTCGGGCT TATGCCAAAGATGTAAAATTTGGTGCAGATGCCCGAGCCTTAATGCTTCAAGGTGTAGACCTTT TAGCCGATGCTGTGGCCGTTACAATGGGGCCAAAGGGAAGAACAGTGATTATTGAGCAGAGTTG GGGAAGTCCCAAAGTAACAAAAGATGGTGTGACTGTTGCAAAGTCAATTGACTTAAAAGATAAA TACAAAAACATTGGAGCTAAACTTGTTCAAGATGTTGCCAATAACACAAATGAAGAAGCTGGGG ATGGCACTACCACTGCTACTGTACTGGCACGCTCTATAGCCAAGGAAGGCTTCGAGAAGATTAG CAAAGGTGCTAATCCAGTGGAAATCAGGAGAGGTGTGATGTTAGCTGTTGATGCTGTAATTGCT GAACTTAAAAAGCAGTCTAAACCTGTGACCACCCCTGAAGAAATTGCACAGGTTGCTACGATTT CTGCAAACGGAGACAAAGAAATTGGCAATATCATCTCTGATGCAATGAAAAAAGTTGGAAGAAA GGGTGTCATCACAGTAAAGGATGGAAAAACACTGAATGATGAATTAGAAATTATTGAAGGCATG AAGTTTGATCGAGGCTATATTTCTCCATACTTTATTAATACATCAAAAGGTCAGAAATGTGAAT TCCAGGATGCCTATGTTCTGTTGAGTGAAAAGAAAATTTCTAGTATCCAGTCCATTGTACCTGC TCTTGAAATTGCCAATGCTCACCGTAAGCCTTTGGTCATAATCGCTGAAGATGTTGATGGAGAA GCTCTAAGTACACTCGTCTTGAATAGGCTAAAGGTTGGTCTTCAGGTTGTGGCAGTCAAGGCTC CAGGGTTTGGTGACAATAGAAAGAACCAGCTTAAAGATATGGCTATTGCTACTGGTGGTGCAGT GTTTGGAGAAGAGGGATTGACCCTGAATCTTGAAGACGTTCAGCCTCATGACTTAGGAAAAGTT GGAGAGGTCATTGTGACCAAAGACGATGCCATGCTCTTAAAAGGAAAAGGTGACAAGGCTCAAA TTGAAAAACGTATTCAAGAAATCATTGAGCAGTTAGATGTCACAACTAGTGAATATGAAAAGGA AAAACTGAATGAACGGCTTGCAAAACTTTCAGATGGAGTGGCTGTGCTGAAGGTTGGTGGGACA AGTGATGTTGAAGTGAATGAAAAGAAAGACAGAGTTACAGATGCCCTTAATGCTACAAGAGCTG CTGTTGAAGAAGGCATTGTTTTGGGAGGGGGTTGTGCCCTCCTTCGATGCATTCCAGCCTTGGA CTCATTGACTCCAGCTAATGAAGATCAAAAAATTGGTATAGAAATTATTAAAAGAACACTCAAA ATTCCAGCAATGACCATTGCTAAGAATGCAGGTGTTGAAGGATCTTTGATAGTTGAGAAAATTA TGCAAAGTTCCTCAGAAGTTGGTTATGATGCTATGGCTGGAGATTTTGTGAATATGGTGGAAAA AGGAATCATTGACCCAACAAAGGTTGTGAGAACTGCTTTATTGGATGCTGCTGGTGTGGCCTCT CTGTTAACTACAGCAGAAGTTGTAGTCACAGAAATTCCTAAAGAAGAGAAGGACCCTGGAATGG GTGCAATGGGTGGAATGGGAGGTGGTATGGGAGGTGGCATGTTCTAACTCCTAGACTAGTGCTT TACCTTTATTAATGAACTGTGACAGGAAGCCCAAGGCAGTGTTCCTCACCAATAACTTCAGAGA AGTCAGTTGGAGAAAATGAAGAAAAAGGCTGGCTGAAAATCACTATAACCATCAGTTACTGGTT TCAGTTGACAAAATATATAATGGTTTACTGCTGTCATTGTCCATGCCTACAGATAATTTATTTT GTATTTTTGAATAAAAAACATTTGTACATTCCTGATACTGGGTACAAGAGCCATGTACCAGTGT ACTGCTTTCAACTTAAATCACTGAGGCATTTTTACTACTATTCTGTTAAAATCAGGATTTTAGT GCTTGCCACCACCAGATGAGAAGTTAAGCAGCCTTTCTGTGGAGAGTGAGAATAATTGTGTACA AAGTAGAGAAGTATCCAATTATGTGACAACCTTTGTGTAATAAAAATTTGTTTAAAGTTAAAAA AAAAAAAAAAAAAAA Download Select all
Length	2319

CDS Information

Location	join(1427..1600,2883..3135,4899..4981,5523..5618, 6025..6118,6783..6951,9979..10078,11028..11273, 11784..11958,12239..12417,13077..13229)
CDS Sequence	>gi\|41399284:118-1839 Homo sapiens heat shock 60kDa protein 1 (chaperonin) (HSPD1), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA ATGCTTCGGTTACCCACAGTCTTTCGCCAGATGAGACCGGTGTCCAGGGTACTGGCTCCTCATCTCACTC GGGCTTATGCCAAAGATGTAAAATTTGGTGCAGATGCCCGAGCCTTAATGCTTCAAGGTGTAGACCTTTT AGCCGATGCTGTGGCCGTTACAATGGGGCCAAAGGGAAGAACAGTGATTATTGAGCAGAGTTGGGGAAGT CCCAAAGTAACAAAAGATGGTGTGACTGTTGCAAAGTCAATTGACTTAAAAGATAAATACAAAAACATTG GAGCTAAACTTGTTCAAGATGTTGCCAATAACACAAATGAAGAAGCTGGGGATGGCACTACCACTGCTAC TGTACTGGCACGCTCTATAGCCAAGGAAGGCTTCGAGAAGATTAGCAAAGGTGCTAATCCAGTGGAAATC AGGAGAGGTGTGATGTTAGCTGTTGATGCTGTAATTGCTGAACTTAAAAAGCAGTCTAAACCTGTGACCA CCCCTGAAGAAATTGCACAGGTTGCTACGATTTCTGCAAACGGAGACAAAGAAATTGGCAATATCATCTC TGATGCAATGAAAAAAGTTGGAAGAAAGGGTGTCATCACAGTAAAGGATGGAAAAACACTGAATGATGAA TTAGAAATTATTGAAGGCATGAAGTTTGATCGAGGCTATATTTCTCCATACTTTATTAATACATCAAAAG GTCAGAAATGTGAATTCCAGGATGCCTATGTTCTGTTGAGTGAAAAGAAAATTTCTAGTATCCAGTCCAT TGTACCTGCTCTTGAAATTGCCAATGCTCACCGTAAGCCTTTGGTCATAATCGCTGAAGATGTTGATGGA GAAGCTCTAAGTACACTCGTCTTGAATAGGCTAAAGGTTGGTCTTCAGGTTGTGGCAGTCAAGGCTCCAG GGTTTGGTGACAATAGAAAGAACCAGCTTAAAGATATGGCTATTGCTACTGGTGGTGCAGTGTTTGGAGA AGAGGGATTGACCCTGAATCTTGAAGACGTTCAGCCTCATGACTTAGGAAAAGTTGGAGAGGTCATTGTG ACCAAAGACGATGCCATGCTCTTAAAAGGAAAAGGTGACAAGGCTCAAATTGAAAAACGTATTCAAGAAA TCATTGAGCAGTTAGATGTCACAACTAGTGAATATGAAAAGGAAAAACTGAATGAACGGCTTGCAAAACT TTCAGATGGAGTGGCTGTGCTGAAGGTTGGTGGGACAAGTGATGTTGAAGTGAATGAAAAGAAAGACAGA GTTACAGATGCCCTTAATGCTACAAGAGCTGCTGTTGAAGAAGGCATTGTTTTGGGAGGGGGTTGTGCCC TCCTTCGATGCATTCCAGCCTTGGACTCATTGACTCCAGCTAATGAAGATCAAAAAATTGGTATAGAAAT TATTAAAAGAACACTCAAAATTCCAGCAATGACCATTGCTAAGAATGCAGGTGTTGAAGGATCTTTGATA GTTGAGAAAATTATGCAAAGTTCCTCAGAAGTTGGTTATGATGCTATGGCTGGAGATTTTGTGAATATGG TGGAAAAAGGAATCATTGACCCAACAAAGGTTGTGAGAACTGCTTTATTGGATGCTGCTGGTGTGGCCTC TCTGTTAACTACAGCAGAAGTTGTAGTCACAGAAATTCCTAAAGAAGAGAAGGACCCTGGAATGGGTGCA ATGGGTGGAATGGGAGGTGGTATGGGAGGTGGCATGTTCTAA Download Select all
CCDS ID	CCDS33357.1

Protein Information

Protein ID	NP_002147.2
Protein Name	Heat shock 60kDa protein 1 (chaperonin)
Molecular Wt. (Da)	60924
Protein Sequence	>3329 MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVII EQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGF EKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKK VGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQS IVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIAT GGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSE YEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCI PALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVN MVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF Download Select all
Length	573
Uniprot ID	P41180
Ensembl Protein ID	ENSP00000296154

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
C	Glutathionylation	447
C	Glutathionylation	447
Y	Phosphorylation	227;-
Y	Phosphorylation	227;-
S	Phosphorylation	70;-
S	Phosphorylation	70;-
T	Phosphorylation	74
T	Phosphorylation	74
K	Acetylation	218
K	Acetylation	218
K	Acetylation	202
K	Acetylation	202
K	Acetylation	82
K	Acetylation	82
K	Acetylation	125
K	Acetylation	125
K	Acetylation	31
K	Acetylation	31
K	Acetylation	352
K	Acetylation	352
K	Acetylation	469
K	Acetylation	469
K	Acetylation	396
K	Acetylation	396
K	Acetylation	269
K	Acetylation	269
K	Acetylation	523
K	Acetylation	523
K	Acetylation	359
K	Acetylation	359
K	Acetylation	130
K	Acetylation	130
K	Acetylation	473
K	Acetylation	473
K	Acetylation	156
K	Acetylation	156
K	Acetylation	249
K	Acetylation	249
K	Acetylation	551
K	Acetylation	551
C	S-Nitrosylation	442
C	S-Nitrosylation	442
T	Phosphorylation	522
T	Phosphorylation	527
T	Phosphorylation	522
T	Phosphorylation	527
T	Phosphorylation	79
T	Phosphorylation	79
T	Phosphorylation	163
T	Phosphorylation	164
T	Phosphorylation	163
T	Phosphorylation	164
S	Phosphorylation	67
S	Phosphorylation	67

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
217	ALDH2	3	NP_000681.2	yeast 2-hybrid	12387818
3675	ITGA3	5431	NP_005492.1	in vivo	11888933
7096	TLR1	3119	NP_003254.2	yeast 2-hybrid	16482509

Pathway Information

Pathway Name	Pathway ID
Legionellosis	hsa05134
RNA degradation	hsa03018
Tuberculosis	hsa05152
Type I diabetes mellitus	hsa04940

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd03344	28-548	GroEL
cl02777	28-548	chaperonin_like superfamily
PTZ00114	24-555	PTZ00114
PRK00013	27-556	groEL
PRK12849	27-556	groEL
TIGR02348	27-551	GroEL
CHL00093	27-553	groEL
PLN03167	27-556	PLN03167
COG0459	27-556	GroEL
cd00309	28-547	chaperonin_type_I_II
pfam00118	47-550	Cpn60_TCP1
cd03333	166-434	chaperonin_like
cd03343	33-539	cpn60
cd03336	33-539	TCP1_beta
TIGR02341	33-551	chap_CCT_beta
TIGR02343	33-521	chap_CCT_epsi
PTZ00212	33-539	PTZ00212
TIGR02345	47-167	chap_CCT_eta
cd03339	41-529	TCP1_epsilon
cd03340	48-157	TCP1_eta
cd03338	47-240	TCP1_delta
TIGR02344	41-552	chap_CCT_gamma
TIGR02342	34-547	chap_CCT_delta
TIGR02340	33-522	chap_CCT_alpha
cd03337	47-202	TCP1_gamma
cd03335	33-193	TCP1_alpha
TIGR02346	47-221	chap_CCT_theta
cd03342	47-545	TCP1_zeta
TIGR02347	47-546	chap_CCT_zeta
cd03341	47-184	TCP1_theta
PRK12850	27-553	groEL
PRK12852	27-556	groEL
PRK12851	27-556	groEL
PRK14104	27-552	PRK14104
TIGR02339	33-539	thermosome_arch

Ontology Information

HPRD ID	3028
Molecular Class	Heat shock protein
Molecular Function	Structural molecule activity (GO:0005198)
Biological Process	Cell growth and/or maintenance (GO:0008151)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO