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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
HYDIN 54768 HYDIN, axonemal central pair apparatus protein  16DKFZp434D0513, KIAA1864, PPP1R31, CILD5 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24777681   2013Cell line : -

Source : Municipal Hospital 24 (Moscow, Russia).

Sample Type : Serum samples

No. of Sample : -

Stage : -

Cloning and expression constructs,Miniarrays of recombinant antigens,Gene expression analysis,RT-PCR,Real-time RT-PCR,flow cytometryPolymorhpism- Taken together, these results suggest frequent and coordinated adaptive immune responses against HYDIN variants in patients with cancer and propose HYDIN as a novel cancer-associated antigen.


Gene Details



NC_000016.9 (70841287..71264625, complement)

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Gene Type protein coding
Gene Family Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
Description This gene encodes a protein that may be involved in cilia motility. Mutations in this gene cause of autosomal recessive primary ciliary dyskinesia-5, a disorder characterized by the accumulation of cerebrospinal fluid within the ventricles of the brain. A duplicate copy of this gene has been found in humans on chromosome 1. [provided by RefSeq, Jan 2013]  
Chromosome 16
Location 16q22.2
Start 70841287  
End 71264625  
Strand -  
Gene Sequence

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Length 423339  
OMIM ID 610812   
HGNC ID HGNC:19368   
Unigene ID Hs.351914   
Ensembl ID ENSG00000157423   
PharmGKB ID PA134866950   

mRNA Information


mRNA ID ?NM_001198542.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS10897.1



Protein Information


      
Protein IDNP_001185471.1
Protein NameHYDIN, axonemal central pair apparatus protein
Molecular Wt. (Da)0
Protein Sequence

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Length 5121  
Uniprot IDP57087
Ensembl Protein ID ENSP00000318416  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation1072
TPhosphorylation4477
KAcetylation4466
YPhosphorylation1507
SPhosphorylation379
SPhosphorylation382
SPhosphorylation379
SPhosphorylation382
YPhosphorylation1972

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam039382261-2365  OmpH
cl214852261-2365  OmpH superfamily
smart009352261-2365  OmpH
COG33342267-2406  MotE
cl216042267-2406  MgtE_N superfamily
pfam085242278-2368  rRNA_processing
cl072272278-2368  rRNA_processing superfamily
pfam066582294-2386  DUF1168
cl229712294-2386  DUF1168 superfamily
pfam153092276-2365  ALMS_motif
cl211542276-2365  ALMS_motif superfamily
PRK139232273-2379  PRK13923
cl215242273-2379  PRK13923 superfamily
COG28252261-2373  HlpA
pfam097452272-2367  DUF2040
cl229752272-2367  DUF2040 superfamily
pfam154582273-2424  NTR2
cl212762273-2424  NTR2 superfamily
pfam140732272-2351  Cep57_CLD
cl224422272-2351  Cep57_CLD superfamily
pfam118612286-2349  DUF3381
cl133252286-2349  DUF3381 superfamily
TIGR025682297-2370  LcrE
cl154542297-2370  HrpJ superfamily
pfam039982262-2370  Utp11
cl021642262-2370  Utp11 superfamily
pfam009922276-2380  Troponin
cl169602276-2380  Troponin superfamily
pfam00635203-269  Motile_Sperm
cl08277203-269  Motile_Sperm superfamily
pfam127182272-2420  Tropomyosin_1
cl228572272-2420  Tropomyosin_1 superfamily
pfam116002271-2397  CAF-1_p150
pfam056722277-2422  MAP7
pfam116002271-2386  CAF-1_p150
pfam116002281-2422  CAF-1_p150
pfam138682266-2424  Trichoplein
pfam116002277-2383  CAF-1_p150
PTZ001212263-2421  PTZ00121
PTZ001212264-2448  PTZ00121
pfam138682264-2422  Trichoplein
PTZ001212274-2563  PTZ00121
PTZ001212271-2578  PTZ00121
COG30642267-2421  TolA
pfam138682258-2424  Trichoplein
PTZ001212271-2422  PTZ00121
PTZ001212272-2544  PTZ00121
pfam056722266-2373  MAP7
pfam138682273-2427  Trichoplein
PTZ001212272-2420  PTZ00121
pfam024632265-2545  SMC_N
pfam007692277-2459  ERM
pfam056722274-2358  MAP7
COG11962263-2547  Smc
PTZ001212255-2420  PTZ00121
pfam102432276-2459  MIP-T3
TIGR027942274-2386  tolA_full
TIGR021692274-2426  SMC_prok_A
pfam028412272-2364  GBP_C
TIGR027942267-2386  tolA_full
PRK095102267-2386  tolA
COG11962276-2471  Smc
pfam153462275-2423  ARGLU
pfam007692266-2389  ERM
pfam138682266-2362  Trichoplein
TIGR027942267-2386  tolA_full
pfam138632258-2365  DUF4200
pfam024632273-2548  SMC_N
pfam038792280-2367  Cgr1
pfam024632277-2424  SMC_N
pfam120372267-2421  DUF3523
pfam007692266-2454  ERM
COG15792274-2420  COG1579
pfam101742274-2547  Cast
pfam077672274-2397  Nop53
pfam049352273-2368  SURF6
pfam097562272-2356  DDRGK
pfam024632276-2421  SMC_N
COG04192274-2451  SbcC
TIGR027942274-2386  tolA_full
pfam020292257-2413  Caldesmon
pfam046152263-2453  Utp14
pfam101742274-2469  Cast
TIGR027942267-2359  tolA_full
pfam101472274-2381  CR6_interact
pfam101742257-2547  Cast
pfam120372278-2427  DUF3523
pfam020292271-2378  Caldesmon
pfam139042268-2423  DUF4207
TIGR021692281-2424  SMC_prok_A
TIGR006182270-2442  sbcc
pfam139042268-2388  DUF4207
COG04192268-2564  SbcC
TIGR021692318-2596  SMC_prok_A
PRK004092274-2422  PRK00409
TIGR021682276-2422  SMC_prok_B
pfam152362262-2369  CCDC66
pfam052762272-2454  SH3BP5
COG04192263-2420  SbcC
pfam024632257-2423  SMC_N
pfam155582258-2422  DUF4659
pfam055572262-2541  MAD
pfam153462271-2365  ARGLU
pfam077672267-2422  Nop53
pfam155582276-2362  DUF4659
TIGR021692263-2545  SMC_prok_A
pfam153462271-2354  ARGLU
pfam002612274-2421  Tropomyosin
pfam078882271-2547  CALCOCO1
pfam155582271-2422  DUF4659
pfam015762286-2360  Myosin_tail_1
COG44872267-2386  COG4487
pfam047472268-2687  DUF612
COG04192255-2544  SbcC
TIGR006182276-2447  sbcc
pfam138682271-2352  Trichoplein
PRK095102273-2386  tolA
pfam040122262-2417  PspA_IM30
pfam142652274-2365  DUF4355
COG38832273-2384  CwlO1
COG11962276-2471  Smc
pfam155582278-2416  DUF4659
pfam152362272-2359  CCDC66
TIGR033192263-2361  RNase_Y
PRK039182273-2422  PRK03918
pfam136542268-2353  AAA_32
COG15792274-2370  COG1579
pfam153462273-2359  ARGLU
COG24332275-2365  COG2433
pfam097262263-2438  Macoilin
pfam142652267-2304  DUF4355
pfam149432272-2362  MRP-S26
COG49422265-2389  EnvC
pfam095072274-2459  CDC27
PTZ001212269-2462  PTZ00121
pfam105952278-2469  UPF0564
TIGR045232274-2467  Mplasa_alph_rch
TIGR021692267-2422  SMC_prok_A
TIGR006062266-2453  rad50
pfam020292275-2548  Caldesmon
pfam142652276-2368  DUF4355
PLN023162326-2393  PLN02316
pfam054832268-2532  SCP-1
pfam149432270-2364  MRP-S26
pfam135142271-2545  AAA_27
COG36112262-2336  DnaB
TIGR021682268-2416  SMC_prok_B
COG04192271-2419  SbcC


Ontology Information


   
HPRD ID10121
Molecular ClassUnclassified
Molecular FunctionExtracellular matrix structural constituent (GO:0005201)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO