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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ID2 | 3398 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 2 | GIG8, bHLHb26 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21956276 | 2012 | Cell line : HCT116 Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR, Western blotting, MTT assay,Transwell assay | Up-regulation | - | The expression of mRNA and protein of Smad4 and Id2 was detected. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Basic helix-loop-helix proteins |
| Description | The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011] | Chromosome | 2 |
| Location | 2p25 |
| Start | 8822113 |
| End | 8824583 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 2471 |
| OMIM ID | 600386 |
| HGNC ID | HGNC:5361 |
| Unigene ID | Hs.180919 |
| Ensembl ID | ENSG00000115738 |
| PharmGKB ID | PA29609 |
mRNA Information
| mRNA ID | NM_002166.4 |
|---|---|
| Exon | join(1..531,861..924,1703..2471) | mRNA Sequence | Download Select all |
| Length | 1402 |
Protein Information
| Protein ID | NP_002157.2 |
|---|---|
| Protein Name | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
| Molecular Wt. (Da) | 14786 |
| Protein Sequence | Download Select all |
| Length | 134 |
| Uniprot ID | Q96HF1 |
| Ensembl Protein ID | ENSP00000274063 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 5 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 118 | ADD1 | 36 | NP_054908.2 | in vitro;in vivo | 10585876 |
| 4617 | MYF5 | 1168 | NP_005584.2 | in vitro;in vivo;yeast 2-hybrid | 9242638 |
| 4654 | MYOD1 | 1166 | NP_002469.2 | in vitro;yeast 2-hybrid | 9242638 |
| 6929 | TCF3 | 918 | NP_003191.1 | in vivo;yeast 2-hybrid | 115 916 539 242 638 |
| 9094 | UNC119 | 4927 | NP_005139.1 | yeast 2-hybrid | 16169070 |
| 55791 | C1orf103 | 17975 | NP_060842.3 | yeast 2-hybrid | 16169070 |
| 84060 | C7orf64 | 13173 | NP_115496.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Hippo signaling pathway | hsa04390 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| TGF-beta signaling pathway | hsa04350 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00083 | 38-79 | HLH |
| cl00081 | 38-79 | HLH superfamily |
| pfam00010 | 37-76 | HLH |
| smart00353 | 38-81 | HLH |
Ontology Information
| HPRD ID | 7357 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Receptor signaling protein activity (GO:0005057) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.