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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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- Structural
- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23669411 | 2013 | Cell line : - Source : The Jackson Laboratory (Bar Harbor, ME). Sample Type : - No. of Sample : Wild type (WT), IDO1 knock-out (IDO1?/?), and Rag1?/?, all on the C57BL/6J, Stage : - | Western blotting, immunoflorescence | Up-regulation | - | The epithelial cell-autonomous survival advantage provided by IDO1 to colon epithelial cells indicate its potential as a therapeutic target. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011] | Chromosome | 8 |
| Location | 8p12-p11 |
| Start | 39771328 |
| End | 39786309 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 14982 |
| OMIM ID | 147435 |
| HGNC ID | HGNC:6059 |
| Unigene ID | Hs.840 |
| Ensembl ID | - |
| PharmGKB ID | PA29869 |
mRNA Information
| mRNA ID | NM_002164.5 |
|---|---|
| Exon | join(1..201,4067..4162,4280..4399,5007..5125,6292..6306, 8744..8843,9661..9778,10913..10964,11415..11563, 14022..14982) | mRNA Sequence | Download Select all |
| Length | 1944 |
Protein Information
| Protein ID | NP_002155.1 |
|---|---|
| Protein Name | indoleamine 2,3-dioxygenase 1 |
| Molecular Wt. (Da) | 45195 |
| Protein Sequence | Download Select all |
| Length | 403 |
| Uniprot ID | Q92922 |
| Ensembl Protein ID | ENSP00000254480 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 57062 | DDX24 | 5860 | NP_065147.1 | yeast 2-hybrid | 16169070 |
| 84988 | PPP1R16A | 16454 | NP_116291.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| African trypanosomiasis | hsa05143 |
| Metabolic pathways | hsa01100 |
| Tryptophan metabolism | hsa00380 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 3294 |
|---|---|
| Molecular Class | Enzyme: Oxygenase |
| Molecular Function | Protein binding (GO:0005515) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P14902 | DB00150 | L-Tryptophan | SmallMoleculeDrug |
| P14902 | DB01065 | Melatonin | SmallMoleculeDrug |