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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IFITM3 | 10410 | interferon induced transmembrane protein 3 | 11 | 1-8U |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21531817 | 2011 | Cell line : - Source : Tissue Bank at Shanghai Jiaotong University Affiliated First Peoples Hospital (Shanghai, Peoples Republic of Chine). Sample Type : CRC tumor and normal tissues No. of Sample : 203 Stage : - | Tissue microarray, immunohistochemistry | Up-regulation | - | IFITM3 is a direct transcriptional target of KLF4 and that dysregulated KLF4 expression leads to aberrant IFITM3 expression, thus contributing to colon cancer progression and metastasis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012] | Chromosome | 11 |
| Location | 11p15.5 |
| Start | 319673 |
| End | 320914 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 1242 |
| OMIM ID | 605579 |
| HGNC ID | HGNC:5414 |
| Unigene ID | Hs.374650 |
| Ensembl ID | ENSG00000142089 |
| PharmGKB ID | PA29655 |
Protein Information
| Protein ID | NP_066362.2 |
|---|---|
| Protein Name | interferon induced transmembrane protein 3 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 133 |
| Uniprot ID | Q8WWY3 |
| Ensembl Protein ID | ENSP00000324122 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 20 |
| S | Phosphorylation | 10 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam04505 | 41-122 | Dispanin |
| cl21637 | 41-122 | DUF4190 superfamily |
Ontology Information
| HPRD ID | 12343 |
|---|---|
| Molecular Class | Integral membrane protein |
| Molecular Function | GTPase activity (GO:0003924) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.