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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 9792144 | 1998 | Cell line : - Source : - Sample Type : Blood sample No. of Sample : 29 CRC patients and 44 healthy persons Stage : - | Whole blood cell culture and stimulation of cytokine secretion, ELISA. | Down-regulation | - | The differential expression of Blood protien were analysed by ELISA in colorectal cancer and normal colorectal tissue. |
| 21859832 | 2011 | Cell line : - Source : - Sample Type : Population-based case control study No. of Sample : CRC cases 1555 and controls 1956 & rectosigmoid junction or rectum 754 and controls 959 Stage : - | TagSNP selection and genotyping | Polymorhpism | - | Three tagSNPs in IFNG was associated with colon cancer (rs1861493,rs2069718 , rs2069727). Genetic variation in the IFN-signaling pathway is important in the etiology of colon and rectal cancer. Two study populations are included. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Interferons |
| Description | This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.[provided by RefSeq, Nov 2009] | Chromosome | 12 |
| Location | 12q14 |
| Start | 68154770 |
| End | 68159741 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4972 |
| OMIM ID | 147570 |
| HGNC ID | HGNC:5438 |
| Unigene ID | Hs.856 |
| Ensembl ID | ENSG00000111537 |
| PharmGKB ID | PA29674 |
mRNA Information
| mRNA ID | NM_000619.2 |
|---|---|
| Exon | join(1..240,1483..1551,1647..1829,4255..4972) | mRNA Sequence | Download Select all |
| Length | 1240 |
CDS Information
| Location | join(127..240,1483..1551,1647..1829,4255..4389) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS8980.1 |
Protein Information
| Protein ID | NP_000610.2 |
|---|---|
| Protein Name | Interferon, gamma |
| Molecular Wt. (Da) | 16776 |
| Protein Sequence | Download Select all |
| Length | 166 |
| Uniprot ID | Q01196 |
| Ensembl Protein ID | ENSP00000300305 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 120 |
| N | Glycosylation | 48 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3459 | IFNGR1 | 127 | NP_000407.1 | in vitro;in vivo | 121 655 211 098 646 000 000 000 |
| 3460 | IFNGR2 | 956 | NP_005525.2 | in vivo | 7673114 |
| 7124 | TNF | 1855 | NP_000585.2 | in vitro;in vivo | 3139842 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| African trypanosomiasis | hsa05143 |
| Allograft rejection | hsa05330 |
| Amoebiasis | hsa05146 |
| Antigen processing and presentation | hsa04612 |
| Chagas disease (American trypanosomiasis) | hsa05142 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Epstein-Barr virus infection | hsa05169 |
| Graft-versus-host disease | hsa05332 |
| Herpes simplex infection | hsa05168 |
| HIF-1 signaling pathway | hsa04066 |
| Inflammatory bowel disease (IBD) | hsa05321 |
| Influenza A | hsa05164 |
| Jak-STAT signaling pathway | hsa04630 |
| Leishmaniasis | hsa05140 |
| Malaria | hsa05144 |
| Measles | hsa05162 |
| Natural killer cell mediated cytotoxicity | hsa04650 |
| Osteoclast differentiation | hsa04380 |
| Proteasome | hsa03050 |
| Regulation of autophagy | hsa04140 |
| Rheumatoid arthritis | hsa05323 |
| Salmonella infection | hsa05132 |
| Systemic lupus erythematosus | hsa05322 |
| T cell receptor signaling pathway | hsa04660 |
| TGF-beta signaling pathway | hsa04350 |
| Toxoplasmosis | hsa05145 |
| Tuberculosis | hsa05152 |
| Type I diabetes mellitus | hsa04940 |
Structure Information
| PDB ID | 1EKU |
|---|---|
| Resolution | 2.9 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B |
| Molecule | INTERFERON GAMMA |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00714 | 24-142 | IFN-gamma |
| cl08283 | 24-142 | IFN-gamma superfamily |
Ontology Information
| HPRD ID | 1320 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165); Protein metabolism (GO:0019538) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P01579 | DB01250 | Olsalazine | SmallMoleculeDrug |
| P01579 | DB01296 | Glucosamine | SmallMoleculeDrug |
| P01579 | DB05676 | Apremilast | SmallMoleculeDrug |