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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
IGF1 3479 Insulin-like growth factor 1 (somatomedin C)  12IGFI; IGF-I; IGF1A 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19784788   2010Cell line : -

Source : Austria (CORSA)

Sample Type : -

No. of Sample : 3,360 Caucasian participants, consisting of 178 colorectal cancer patients, 328 patients with high risk polyps, 1,059 patients with low risk colorectal polyps, and 1,795 colonoscopy-negative controls

Stage : -

Multiple logistic regression.Amplification-SNP rs6214 of IGF1 could have an impact on developing colorectal cancer and colorectal polyps with villous elements

22810696   2012Cell line : -

Source : Biospecimen Core Resources

Sample Type : CRC tumor and normal tissue

No. of Sample : 276

Stage : -

Whole-genome sequencing, Affymetrix SNP6.0 arrays.Amplification--

20935157   2010Cell line : -

Source : -

Sample Type : -

No. of Sample : 764 CRC case and 775 controls

Stage : -

GenotypingPolymorhpism-IGF1 pathway polymorphisms are potential predictive/prognostic molecular markers for cetuximab efficacy in wt KRAS mCRC patients.



21932422   2012Cell line : -

Source : 2nd Departament of The Gastrointestinal Surgery of the Medical University in Bia?ystok.

Sample Type : Serum sample

No. of Sample : 125 CRC patients

Stage : -

ELISAUp-regulation-A significant positive association between circulating IGF1 levels and risk of advanced colorectal adenoma, suggesting that IGF1 is associated with the pivotal precursor to colorectal cancer.

22166477   2011Cell line : -

Source : North Carolina colon cancer study.

Sample Type : -

No. of Sample : African Americans (231 cases and 306 controls) and Whites (297 cases, 530 controls)

Stage : -

 Immunoassay ELISA, Up-regulation-IGF I can be one of the factors of the prognosis in colorectal cancer development.

Significant increased serum concentration of IGF I in patients with locally advanced colorectal cancer (pT3 and pT4) comparing to less advanced (pT2).

22565227   2012Cell line : -

Source : Medline, EMBASE, OVID and Web of Science.

Sample Type : -

No. of Sample : 19 epidemiological studies containing 5,155 cases and 9,420 controls

Stage : -

PCR and fragment analysis, Genotyping, Enzyme immunoassaysUp-regulation-Association between insulin pathway-related genes and elevated colon cancer risk in Whites but not in African Americans observed.

23269623   2012Cell line : -

Source : -

Sample Type : Plasma Sample

No. of Sample : -

Stage : -

Meta AnalysisUp-regulation-

Meta-analysis showed that high level IGF-I and IGF-II significantly increased CRC risk.

A meta-analysis of 19 epidemiological studies containing 5,155 cases and 9,420 controls related with the association of circulation insulin-like growth factor peptides and CRC risk was carried out.

21475834   2009Cell line : -

Source : University of Southern California/Norris Comprehensive Cancer Center (USC/NCCC)

Sample Type : -

No. of Sample : 130 mCRC patients

Stage : TNM Stage IV

-Up-regulation-Elevated plasma IGF-1 may promote the growth of dysplastic ACF and play a key role in colon carcinogenesis in male individuals.

The results of multiple regression analysis revealed that increased plasma IGF-1 levels are associated with the number of dysplastic ACF present, and may be an independent risk factor for CRC.


Gene Details



Chromosome: 12; NC_000012.11 (102789645..102874378, complement)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]  
Chromosome 12
Location 12q23.2
Start 102395867  
End 102481786  
Strand -  
Gene Sequence

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Length 85920  
OMIM ID 147440   
HGNC ID HGNC:5464   
Unigene ID Hs.160562    
Ensembl ID ENSG00000017427   
PharmGKB ID -   

mRNA Information


mRNA ID NM_000618.3
Exon join(1187..1468,5988..6144,62097..62278,79221..85920)  
mRNA Sequence

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Length 7321  



CDS Information


   
Location join(1406..1468,5988..6144,62097..62278,79221..79280)
CDS Sequence

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CCDS ID CCDS9091.1



Protein Information


      
Protein IDNP_000609.1
Protein NameInsulin-like growth factor 1 (somatomedin C)
Molecular Wt. (Da)14634
Protein Sequence

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Length 153  
Uniprot IDQ13761
Ensembl Protein ID ENSP00000308051  



Post-translational Modification Information (Source : HPRD)


Residue Type site
CDisulfide Bridge54;96
CDisulfide Bridge66;109
CDisulfide Bridge95;100
CDisulfide Bridge54;96
CDisulfide Bridge66;109
CDisulfide Bridge95;100
KProteolytic Cleavage113
AProteolytic Cleavage115
PProteolytic Cleavage114
KProteolytic Cleavage116
KProteolytic Cleavage113
PProteolytic Cleavage114
AProteolytic Cleavage115
KProteolytic Cleavage116

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
3416IDE894NP_004960.2in vitro1733942   
3480IGF1R932NP_000866.1in vitro1852007   
3484IGFBP1897NP_000587.1in vitro10350456   
3485IGFBP2898NP_000588.2in vitro11063745   
3486IGFBP3899NP_001013416.1in vitro;in vivo11600567   
3487IGFBP4900NP_001543.2in vitro9722589   
3488IGFBP5901NP_000590.1in vitro;in vivo94   973   241   147   105   
3489IGFBP6902NP_002169.1in vitro7683646   


Pathway Information


                                                                                                                                                            
Pathway Name Pathway ID
Aldosterone-regulated sodium reabsorption hsa04960
AMPK signaling pathway hsa04152
Dilated cardiomyopathy hsa05414
Focal adhesion hsa04510
FoxO signaling pathway hsa04068
Glioma hsa05214
HIF-1 signaling pathway hsa04066
Hypertrophic cardiomyopathy (HCM) hsa05410
Inflammatory mediator regulation of TRP channels hsa04750
Longevity regulating pathway - mammal hsa04211
Longevity regulating pathway - multiple species hsa04213
Long-term depression hsa04730
Melanoma hsa05218
mTOR signaling pathway hsa04150
Oocyte meiosis hsa04114
Ovarian steroidogenesis hsa04913
p53 signaling pathway hsa04115
Pathways in cancer hsa05200
PI3K-Akt signaling pathway hsa04151
Progesterone-mediated oocyte maturation hsa04914
Prostate cancer hsa05215
Proteoglycans in cancer hsa05205
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014
Signaling pathways regulating pluripotency of stem cells hsa04550
Transcriptional misregulation in cancer hsa05202


Structure Information


PDB ID1B9G
Resolution-
MethodSOLUTION NMR
Chains A  
Molecule PROTEIN (GROWTH FACTOR IGF-1)  
Model View



Domain Information




ID Location Description
cd0436849-116  IlGF
cl0245349-116  IlGF_like superfamily
cd0436749-109  IlGF_insulin_like
smart0007851-109  IlGF
pfam0004951-109  Insulin
cd0010153-109  IlGF_like
cd0436653-109  IlGF_insulin_bombyxin_like
cd0436553-109  IlGF_relaxin_like


Ontology Information


   
HPRD ID323
Molecular ClassUnknown
Molecular FunctionG-protein coupled receptor activity (GO:0004930)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO