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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IGF2 | 3481 | insulin-like growth factor 2 | 11 | FLJ44734, IGF-II |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20682317 | 2010 | Cell line : - Source : The Nurses Health Study and the Health Professionals Follow-up Study Sample Type : - No. of Sample : 1178CRC specimens Stage : - | Bisulfite DNA treatment and real-time PCR (MethyLight), Pyrosequencing | Hypomethylation | - | IGF2 DMR0 hypomethylation in colorectal tumor samples is associated with shorter survival time, so it might be developed as a prognostic biomarker. Methylation at the IGF2 DMR0 was successfully measured in 1105 (94%) of 1178 samples. Colorectal tumors had significantly less methylation at the DMR0 compared with matched, normal colonic mucosa (P < .0001; N = 51). |
| 22121898 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 26 sporadic colorectal cancer, 35 familial adenomatous polyposis and 19 hereditary nonpolyposis colorectal cancer Stage : - | Pyrosequencing | Hypomethylation | - | Methylation alterations at the IGF2 locus are more extensive than previously reported and DMR2 hypomethylation in lymphocyte DNA might be a specific epigenetic biomarker for familial adenomatous polyposis patients. |
| 18541649 | 2008 | Cell line : - Source : Colchester General Hospital (Essex, UK) Sample Type : - No. of Sample : - Stage : - | Pyrosequencing | Hypomethylation | - | IGF2 DMR0 hypomethylation has diagnostic potential for colon cancer rather than value as a surrogate biomarker for constitutive LOI. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. | Chromosome | 11 |
| Location | 11p15.5 |
| Start | 2129112 |
| End | 2149603 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 20492 |
| OMIM ID | 147470 |
| HGNC ID | HGNC:5466 |
| Unigene ID | Hs.272259 |
| Ensembl ID | ENSG00000167244 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001007139.5 |
|---|---|
| Exon | join(1..478,1797..2038,14075..14237,15939..16087, 16381..20492) | mRNA Sequence | Download Select all |
| Length | 5156 |
CDS Information
| Location | join(9308..9469,14075..14237,15939..16087,16381..16617) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS44517.1 |
Protein Information
| Protein ID | NP_000603.1 |
|---|---|
| Protein Name | insulin-like growth factor 2 |
| Molecular Wt. (Da) | 17640 |
| Protein Sequence | Download Select all |
| Length | 180 |
| Uniprot ID | Q92769 |
| Ensembl Protein ID | ENSP00000357621 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| R | Proteolytic Cleavage | 95 |
| R | Proteolytic Cleavage | 131 |
| T | Glycosylation | 99 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3416 | IDE | 894 | NP_004960.2 | in vitro | 1733942 |
| 3480 | IGF1R | 932 | NP_000866.1 | in vivo | 9972281 |
| 3482 | IGF2R | 928 | NP_000867.2 | in vitro;in vivo | 77 974 789 722 981 |
| 3484 | IGFBP1 | 897 | NP_000587.1 | in vitro | 10810289 |
| 3485 | IGFBP2 | 898 | NP_000588.2 | in vitro;in vivo | 171 491 687 815 532 000 000 |
| 3486 | IGFBP3 | 899 | NP_001013416.1 | in vitro | 10407151 |
| 3487 | IGFBP4 | 900 | NP_001543.2 | in vitro | 9722589 |
| 3488 | IGFBP5 | 901 | NP_000590.1 | in vitro;in vivo | 9497324 |
| 3489 | IGFBP6 | 902 | NP_002169.1 | in vitro | 7683646 |
| 5340 | PLG | 1417 | NP_000292.1 | in vitro | 15642732 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Proteoglycans in cancer | hsa05205 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04368 | 28-91 | IlGF |
| cl02453 | 28-91 | IlGF_like superfamily |
| pfam08365 | 112-166 | IGF2_C |
| cl07110 | 112-166 | IGF2_C superfamily |
| smart00078 | 30-84 | IlGF |
| pfam00049 | 30-84 | Insulin |
| cd04367 | 28-84 | IlGF_insulin_like |
| cd00101 | 32-84 | IlGF_like |
| cd04366 | 32-84 | IlGF_insulin_bombyxin_like |
| cd04365 | 32-84 | IlGF_relaxin_like |
Ontology Information
| HPRD ID | 4517 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.