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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
IGFBP7 3490 Insulin-like growth factor binding protein 7  4AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20027224   2010Cell line : COLO 320DM

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

 Illumina GoldenGate DNA methylation technology.Down-regulation-Promoter DNA hypermethylation of IGFBP7 was associated with silencing of the gene mediate BRAF(V600E)-induced cellular senescence and apoptosis.

17048309   2006Cell line : RKO, SW 620

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Methylation-specific PCR, bisulfite sodium PCR Methylation-GFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis and its expression is associated with DNA hypomethylation of exon 1.

IGFBP7 protein could inhibit growth rate, decrease colony formation activity, and induce apoptosis in RKO and SW620 cells, suggesting it a potential tumor suppressor protein in colorectal carcinogenesis.

19638426   2010Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

 Luciferase and chromatin immunoprecipitation assays.Methylation-In CRC cell lines, the silencing of IGFBP7 expression was correlated with high levels of DNA methylation and low levels of histone H3K4 methylation.

Epigenetic inactivation of IGFBP7 appears to play a key role in tumorigenesis of CRCs with CIMP by enabling escape from p53-induced senescence.

19861408   2009Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Methylation-IGFBP7 is epigenetically silenced, which seems to be a critical step in melanoma genesis.

Human metastatic melanoma samples IGFBP7 is epigenetically silenced and at an even higher frequency than that found in primary melanomas.

IGFBP7 acts as anticancer agent.

23255887   2012Cell line : -

Source : Department of Surgery, Ryhov County Hospital (Jnkping, Sweden) and the Department of Pathology, National Cancer Hospital (Tamhiep, Hanoi, Vietnam).

Sample Type : CRC tumor and normal tissue

No. of Sample : 101 CRC patients

Stage : TNM stage I-IV

Methylation specific RT-PCRMethylation-IGFBP7 has been suggested to play a tumour suppressor role against colorectal carcinogenesis.

Methylation of the APC and IGFBP7 gene promoter region in cancerous tissue, in combination with the predominance of methylation in normal tissue, may serve as a prognostic factor in CRC.

19363822   2009Cell line : SW 480, Caco 2, CC 531

Source : -

Sample Type : -

No. of Sample : -

Stage : -

 RT-PCR, immunohistochemistryUnknown-Fibroblasts-colorectal cancer cells interaction induces the expression of IGFBP7, which indicates tumor-stroma interactions may play an important role in colorectal cancer development.

20433702   2010Cell line : SW 480

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Western blotting, ELISA, 2-D Gel electrophoresis and mass spectrometryUnknown-The downregulation of HSP60 induced by IGFBP7 may be, at least in part, responsible for IGFBP7's tumor suppressive biological behaviour in CRC.

21525788   2011Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Up-regulation-Results indicate that IGFBP3 and 7 cannot be simply considered as tumor suppressors but have additional properties, which become evident only during cancer progression and metastasis formation.

68 human CRC samples was higher in UICC stages II and III than in stages I and IV were included.

High levels returned gradually to normal thereafter, it could be assumed that the up-regulation of IGFBPs is vital during the process of homing into the liver and early metastatic dissemination.


Gene Details



Chromosome: 4; NC_000004.11 (57897237..57976551, complement)

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Gene Type protein coding
Gene Family Immunoglobulin superfamily / I-set domain containing, Immunoglobulin superfamily / Immunoglobulin-like domain containing, Fibronectin type III domain containing
Description This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]  
Chromosome 4
Location 4q12
Start 57031071  
End 57110385  
Strand -  
Gene Sequence

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Length 79315  
OMIM ID 602867   
HGNC ID HGNC:5476   
Unigene ID Hs.479808   
Ensembl ID ENSG00000163453   
PharmGKB ID PA29709   

mRNA Information


mRNA ID NM_001303269.1
Exon complement(<79224..>79315)  
mRNA Sequence

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Length 1137  



CDS Information


   
Location join(35..509,69453..69562,77075..77191,77834..77960, 79050..79069)
CDS Sequence

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CCDS ID CCDS3512.1



Protein Information


      
Protein IDNP_001240764.1
Protein NameInsulin-like growth factor binding protein 7
Molecular Wt. (Da)26173
Protein Sequence

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Length 279  
Uniprot IDP14635
Ensembl Protein ID ENSP00000256442  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KProteolytic Cleavage97

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
3479IGF1936AAA52539.1in vitro8939990   
3481IGF2939NP_001121070.1in vitro8939990   
3624INHBA929NP_002183.1in vitro;in vivo10859029   
3627CXCL10930NP_001556.2in vivo12847218   
3630INS1455NP_000198.1in vitro9388210   
6352CCL51751NP_002976.2in vitro12847218   
6366CCL214113NP_002980.1in vivo12847218   
6382SDC11718NP_002988.3in vivo14521955   
7422VEGFA1889NP_001020537.2in vitro12407018   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00096177-262  Ig
cl11960177-262  Ig superfamily
cd00104113-156  KAZAL_FS
cl00097113-156  KAZAL_FS superfamily
cd04968160-265  Ig3_Contactin_like
cd05851160-265  Ig3_Contactin-1
cd05731179-266  Ig3_L1-CAM_like
cd05856174-265  Ig2_FGFRL1-like
smart00280111-156  KAZAL
cd05893177-265  Ig_Palladin_C
pfam07648114-156  Kazal_2
cd05724166-265  Ig2_Robo
cd04978174-266  Ig4_L1-NrCAM_like
cd05725177-265  Ig3_Robo
cd05744177-265  Ig_Myotilin_C_like
cd05745174-265  Ig3_Peroxidasin
cd05732172-260  Ig5_NCAM-1_like
cd05723177-265  Ig4_Neogenin
cd05858174-265  Ig3_FGFR-2
cd05730173-265  Ig3_NCAM-1_like
cd05728166-265  Ig4_Contactin-2-like
cd05746177-264  Ig4_Peroxidasin
cd05722161-265  Ig1_Neogenin
cd07693160-266  Ig1_Robo
cd05729174-265  Ig2_FGFR_like
pfam13927160-252  Ig_3
cd04974174-265  Ig3_FGFR
cd05892177-265  Ig_Myotilin_C
smart0012130-90  IB
cl0247230-90  IGFBP superfamily
pfam13895159-265  Ig_2
cd05743174-255  Ig_Perlecan_D2_like
cd05876177-265  Ig3_L1-CAM
pfam07679160-265  I-set
smart00410174-265  IG_like
smart00409174-265  IG
smart00408174-255  IGc2


Ontology Information


   
HPRD ID452
Molecular ClassAdhesion molecule
Molecular FunctionKinase binding (GO:0019900)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q16270DB00030Insulin RegularBiotechDrug
Q16270DB00071Insulin, porcineBiotechDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO