Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IGHM | 3507 | immunoglobulin heavy constant mu | 14 | MU; VH; AGM1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : - No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Down-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Immunoglobulins / IGH locus |
| Description | Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).[supplied by OMIM, Aug 2010] | Chromosome | 14 |
| Location | 14q32.33 |
| Start | 105851966 |
| End | 105856217 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4252 |
| OMIM ID | 147020 |
| HGNC ID | HGNC:5541 |
| Unigene ID | Hs.510635 |
| Ensembl ID | ENSG00000211899 |
| PharmGKB ID | PA29730 |
CDS Information
| Location | join(1..>312,403..738,984..1301,1481..1813,3955..4070, 4244..4252) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | N/A |
Protein Information
| Protein ID | |
|---|---|
| Protein Name | immunoglobulin heavy constant mu |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | |
| Ensembl Protein ID |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 198 |
| N | Glycosylation | 362 |
| T | Phosphorylation | 470 |
| S | Phosphorylation | 472 |
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 973 | CD79A | 203 | NP_001774.1 | in vitro | 9561918 |
| 3250 | HPR | 773 | NP_066275.3 | in vitro | 10085035 |
| 5747 | PTK2 | 2859 | NP_005598.3 | in vitro;in vivo | 11389892 |
| 55722 | CEP72 | 7685 | NP_060610.2 | yeast 2-hybrid | 16189514 |
| 56893 | UBQLN4 | 5670 | NP_064516.2 | yeast 2-hybrid | 16713569 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
No matching records could be found.
Ontology Information
| HPRD ID | 455 |
|---|---|
| Molecular Class | Immunoglobulin |
| Molecular Function | Kinase binding (GO:0019900) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.